Patents by Inventor David E. Hamer

David E. Hamer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-Hydroxylation process
    Patent number: 4338250
    Abstract: A process for preparing biologically active 1.alpha.-hydroxyvitamin D compounds from vitamin D compounds by hydroxylation at carbon 1 and subsequent photochemical isomerization, and novel intermediates and products resulting from this process are provided.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: July 6, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
    Patent number: 4265822
    Abstract: A method for preparing 1.alpha.-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds which comprises allylically oxidizing a 5,6-trans-vitamin D compound, subjecting the oxidation product to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated compound.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: May 5, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Process for preparing 1.alpha.-hydroxylated compounds
    Patent number: 4260549
    Abstract: An improved method for the preparation of 1.alpha.-hydroxylated vitamin D compounds involving directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof, wherein the 1.alpha.-hydroxycyclovitamin D intermediate is solvolyzed directly, without first converting the 1-hydroxy group to a 1-O-acyl function as a protective measure.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: April 7, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, David E. Hamer
  • Process for preparing 1.alpha.-hydroxyvitamin D compounds from 1.alpha.-hydroxy-3,5-cyclovitamin D compounds
    Patent number: 4234495
    Abstract: A method for preparing 1.alpha.-hydroxyvitamin D compounds from 1.alpha.-hydroxy-3,5-cyclovitamin D compounds which comprises solvolyzing the 3,5-cyclovitamin D compound, exposing the solvolysis reaction products to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated vitamin D compounds.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: November 18, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Process for preparing 1.alpha.-hydroxylated compounds
    Patent number: 4202829
    Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors of derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: May 13, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Process for preparing 1.alpha.-hydroxylated compounds
    Patent number: 4195027
    Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 25, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren