Patents by Inventor David E. Heinrichs

David E. Heinrichs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220195018
    Abstract: A pharmaceutical composition comprising an agent that increases the expression of a purR gene in a bacterium and a method of attenuating, preventing or treating a bacterial infection in a subject comprising administering to the subject an agent that increases the expression of a purR gene.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 23, 2022
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: David E. HEINRICHS, Ronald S. FLANNAGAN
  • Patent number: 8729013
    Abstract: Methods of inhibiting S. aureus are provided. The methods include inhibition of polypeptides involved in the transport of the siderophore, staphylobactin.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: May 20, 2014
    Assignee: The University of Western Ontario
    Inventors: David E. Heinrichs, Suzanne Dale
  • Patent number: 8637657
    Abstract: The present invention relates to methods of inhibiting S. aureus comprising inhibiting siderophore-mediated iron uptake, for example, staphyloferrm-mediated iron uptake Such methods of inhibiting S. aureus include the inhibition of staphyloferrm A- and staphyloferrm B-mediated uptake either by inhibiting expression or activity of staphyloferrm A and B or by inhibiting transport of staphyloferrm A and B The methods as provided would be useful for treating S. aureus infection.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: January 28, 2014
    Inventors: David E. Heinrichs, Federico Beasley, Enríque Vines, Johnson Cheung
  • Publication number: 20120322849
    Abstract: Methods of inhibiting S. aureus are provided. The methods include inhibition of polypeptides involved in the transport of the siderophore, staphylobactin.
    Type: Application
    Filed: May 4, 2012
    Publication date: December 20, 2012
    Inventors: David E. Heinrichs, Suzanne Dale
  • Publication number: 20110245321
    Abstract: The present invention relates to methods of inhibiting S. aureus comprising inhibiting siderophore-mediated iron uptake, for example, staphyloferrm-mediated iron uptake Such methods of inhibiting S. aureus include the inhibition of staphyloferrm A- and staphyloferrm B-mediated uptake either by inhibiting expression or activity of staphyloferrm A and B or by inhibiting transport of staphyloferrm A and B The methods as provided would be useful for treating S.
    Type: Application
    Filed: August 14, 2009
    Publication date: October 6, 2011
    Inventors: David E. Heinrichs, Federico Beasley, Enríque Vines, Johnson Cheung
  • Publication number: 20110206685
    Abstract: Isolation of an iron regulated, nme-gene operon (designated sbn) from Staphylococcus aureus (RN6390), responsible for the biosynthesis of staphylobactm, a novel S. aureus siderophore Methods for treating or preventing a disease or condition caused by S. aureus infection, as well as methods for identifying agents that inhibit the biosynthesis of staphylobactm or inhibit the expression of genes in said sbn operon are further disclosed.
    Type: Application
    Filed: September 8, 2005
    Publication date: August 25, 2011
    Inventors: David E. Heinrichs, Suzanne Dale
  • Publication number: 20100129349
    Abstract: Methods of inhibiting S. aureus are provided. The methods include inhibition of polypeptides involved in the transport of the siderophore, staphylobactin.
    Type: Application
    Filed: October 2, 2009
    Publication date: May 27, 2010
    Inventors: David E. Heinrichs, Suzanne Dale
  • Patent number: 6570006
    Abstract: Described are a novel gene (waaP) and a protein (WaaP) which has an enzymatic activity that is involved in heptose modification in the lipopolysaccharide of bacterial membranes. Also described is a method and series of compounds which are active against bacterial pathogens wherein the method comprises the administration of sufficient amount of an inhibitor of WaaP protein activity in gram negative bacteria.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 27, 2003
    Assignee: University of Guelph
    Inventors: Chris Whitfield, Jeremy A. Yethon, David E. Heinrichs