Abstract: Described herein is the development of synthetic routes to produce a wide variety of substituted phenanthridines, specifically, multidentate phenanthridine-containing ligand frameworks capable of anchoring to Pt via more than one binding site and with the phenanthridinyl moiety co-planar to the coordination plane of Pt. The multidentate chelation is designed to attenuate the reactivity of the platinum complex in vivo, and ultimately help mitigate side effects. In addition, the geometry of phenanthridine binding to the metal centre is altered compared to in phenanthriplatin, thanks to the constraints of the ligand geometry. By enforcing coplanar binding with the metal's square planar coordination plane, these compounds exhibit altered modes of activity, and should hence enhance/change the spectrum of activity of our prodrug candidates compared with phenanthriplatin.

Abstract: The present disclosure relates to new metal complexes, including derivatives thereof, methods of making the metal complexes, and uses thereof, including uses, for example, as photosensitizers and as photocatalysts. In an embodiment, a metal complex having the structure of Formula (I): a salt, hydrate, solvate, tautomer, optical isomer, or combination thereof.

Abstract: Described herein is the development of synthetic routes to produce a wide variety of substituted phenanthridines, specifically, multidentate phenanthridine-containing ligand frameworks capable of anchoring to Pt via more than one binding site and with the phenanthridinyl moiety co-planar to the coordination plane of Pt. The multidentate chelation is designed to attenuate the reactivity of the platinum complex in vivo, and ultimately help mitigate side effects. In addition, the geometry of phenanthridine binding to the metal centre is altered compared to in phenanthriplatin, thanks to the constraints of the ligand geometry. By enforcing coplanar binding with the metal's square planar coordination plane, these compounds exhibit altered modes of activity, and should hence enhance/change the spectrum of activity of our prodrug candidates compared with phenanthriplatin.

Abstract: A hydraulic manifold assembly includes a manifold containing a plurality of hydraulic channels that direct fluid to a centralized location and a package disposed at the centralized location to measure fluid pressure at pressure ports corresponding to the hydraulic channels. The manifold assembly directs fluid to the single package rather than scattering fluid outputs to multiple sensor locations, simplifying the overall assembly configuration.

Abstract: A manufacturing process, system, and method is described that facilitates the assembly and testing of a hydraulic manifold with integral closed loop pressure sensing and feedback.

Abstract: A hydraulic manifold assembly includes a manifold containing a plurality of hydraulic channels that direct fluid to a centralized location and a package disposed at the centralized location to measure fluid pressure at pressure ports corresponding to the hydraulic channels. The manifold assembly directs fluid to the single package rather than scattering fluid outputs to multiple sensor locations, simplifying the overall assembly configuration.

Abstract: A closed loop adaptive fluid control system and method for use in hydraulic applications monitors one or more fluid characteristics, such as pressure, flow rate, accumulation time in an actuator, fill volume, etc., and compares the characteristic with a target response. A fluid characteristic sensor detects at least one fluid characteristic at a hydraulically-actuated device that is actuated by a electrically-operated. The sensor sends a device signal corresponding to the actual sensed characteristic to an electronic controller, which compares the device signal with a target response. The controller then identifies any differences between the device signal and the target response and provides a feedback signal to the electrically-operated valve to adjust the current to the valve, which in turn adjusts the electrically-operated valve so that the device signal corresponding to the sensed characteristic at the device converges toward the target response.

Abstract: A pulse width modulated (PWM) valve-based hydraulic control system is disclosed. In one embodiment, a feedback control system includes a controller that receives a pressure command signal and a pressure feedback signal. The controller generates a duty cycle control signal that controls a PWM valve. The PWM valve provides a control pressure Pc to control a load, such as an actuator of an automatic transmission system. A pressure sensor measures the control pressure Pc and provides the pressure feedback signal. In another embodiment, a compensator provides compensation for linear and nonlinear effects in the pressure feedback signal, based at least in part, on other inputs, such as fluid temperature. In other embodiments, a plurality of controllers are provided, and a controller is selected by a switching logic processor, or by phase-in and phase-out filters, based on the pressure feedback signal and other inputs. A re-calibration process for the Pc versus duty cycle response of the PWM valve is also disclosed.

Abstract: A manufacturing process, system, and method is described that facilitates the assembly and testing of a hydraulic manifold with integral closed loop pressure sensing and feedback.

Abstract: A hydraulic manifold assembly includes a manifold containing a plurality of hydraulic channels that direct fluid to a centralized location and a package disposed at the centralized location to measure fluid pressure at pressure ports corresponding to the hydraulic channels. The manifold assembly directs fluid to the single package rather than scattering fluid outputs to multiple sensor locations, simplifying the overall assembly configuration.

Abstract: The present invention relates to a method of analyzing accuracy of linear sensor output based on a theoretical prediction of the output model. The method comprises steps of: analyzing a statistically significant number of linear sensors to obtain operating profiles at two or more operating conditions; individually testing a linear sensor to obtain at least four data points; developing a theoretical prediction of the output model for each operating condition from the four data points; and comparing accuracy of the relationship between the theoretical prediction of the output model to sensor output in the operating profile corresponding to a given input for the same operating condition. Also disclosed are calibration algorithms associated therewith, as well as mechatronic units and further assemblies therefrom.

Abstract: An electro-hydraulic manifold assembly with a plurality of solenoid operated valves disposed on a manifold block and each operable to control pressure from the inlet to a separate outlet. Sensing ports are provided in each outlet with a pressure sensor sealed over the sensing port for providing a signal indicative of the sensed pressure. The pressure sensors are mounted on a lead frame and connected to conductive strips in the lead frame. The lead frame has slots therein which permit the frame to be simultaneously electrically connected by bayonet connection to the terminals on each solenoid valve as the transducers are sealed over the sensing ports and the lead frame attached to the manifold block.

Abstract: A solenoid operated three port pressure control valve assembly of the exhaust pressure bleed type. The valve for the inlet pressure supply port includes a pressure responsive diaphragm with the supply port obturator attached. A bleed orifice in the diaphragm provides viscous dampening of the movement of the obturator and minimizes inlet valve flutter. The valve assembly is disclosed in both normally open and normally closed configurations.

Abstract: An electro-hydraulic manifold assembly with a plurality of solenoid operated valves disposed on a manifold block and each operable to control pressure from the inlet to a separate outlet. Sensing ports are provided in each outlet with a pressure sensor sealed over the sensing port for providing a signal indicative of the sensed pressure. The pressure sensors are mounted on a lead frame and connected to conductive strips in the lead frame. The lead frame has slots therein which permit the frame to be simultaneously electrically connected by bayonet connection to the terminals on each solenoid valve as the transducers are sealed over the sensing ports and the lead frame attached to the manifold block.

Abstract: An electro-hydraulic manifold assembly including integral pressure transducers for providing real time indication of the control pressure signal output of each electrically operated valve on the manifold. The transducer dies are adhesively attached to circuit boards and the leads ultrasonically attached to pads on the ends of conductive strips on the circuit boards. Upstanding electrical connectors are attached to the circuit boards and connected to the dies which are potted over with silicone potting compound and the circuit board attached to the manifold. An electrical lead frame commonly engages the solenoid terminals and the pressure transducer terminals in bayonet style connection through slots in the lead frame.

Abstract: An electro-hydraulic controller having a plurality of solenoid operated valves mounted in inlet and outlet ported valving cavities on a non-metallic manifold block. The manifold block has inlet and outlet ports sealed by a gasket for communication with corresponding ports in a metallic base to which the manifold block is attached. The base is sufficiently rigid to resist prohibitive deflection when exposed to the forces of fluid pressure when secured over the open hydraulic channels of an automatic transmission shift circuit deck. The non-metallic manifold may be fabricated to “Net Shape” without costly secondary operations to achieve critical dimensions.

Abstract: A solenoid operated three port pressure control valve assembly of the exhaust pressure bleed type. The valve for the inlet pressure supply port includes a pressure responsive diaphragm with the supply port obturator attached. A bleed orifice in the diaphragm provides viscous dampening of the movement of the obturator and minimizes inlet valve flutter. The valve assembly is disclosed in both normally open and normally closed configurations.

Abstract: An electro-hydraulic controller having a plurality of solenoid operated valves mounted in inlet and outlet ported valving cavities on a non-metallic manifold block. The manifold block has inlet and outlet ports sealed by a gasket for communication with corresponding ports in a metallic base to which the manifold block is attached. The base is sufficiently rigid to resist prohibitive deflection when exposed to the forces of fluid pressure when secured over the open hydraulic channels of an automatic transmission shift circuit deck. The non-metallic manifold may be fabricated to “Net Shape” without costly secondary operations to achieve critical dimensions.