Abstract: An annular elastomeric packer for a blowout preventer includes a plurality of circumferentially spaced inserts, wherein at least one of the plurality of inserts includes a rib, and a foot pivotally coupled to the rib, and an elastomeric body coupled to the plurality of inserts and including an inner surface, wherein the foot is configured to resist deformation of the elastomeric body in response to the blowout preventer actuating from a first position to a second position.

Abstract: An annular elastomeric packer for a blowout preventer includes a plurality of circumferentially spaced inserts, wherein at least one of the plurality of inserts includes a rib, and a foot pivotally coupled to the rib, and an elastomeric body coupled to the plurality of inserts and including an inner surface, wherein the foot is configured to resist deformation of the elastomeric body in response to the blowout preventer actuating from a first position to a second position.

Abstract: The present invention provides methods of treating cancer by inhibiting MECP2 and identifying cancers that will respond to therapy using MECP2 as a biomarker.

Abstract: The present invention provides methods of treating cancer by inhibiting MECP2 and identifying cancers that will respond to therapy using MECP2 as a biomarker.

Abstract: Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics. Further provided are methods for using changes caused by expression of the complementing genes to indirectly identify associated genes to be used as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics.

Abstract: An automatic, self-contained device for detecting toxic agents in a water supply includes an analyzer for detecting at least one toxic agent in a water sample, introducing means for introducing a water sample into the analyzer and discharging the water sample from the analyzer, holding means for holding a water sample for a pre-selected period of time before the water sample is introduced into the analyzer, and an electronics package that analyzes raw data from the analyzer and emits a signal indicating the presence of at least one toxic agent in the water sample.

Abstract: Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics. Further provided are methods for using changes caused by expression of the complementing genes to indirectly identify associated genes to be used as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MD2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.

Abstract: A freeze resistant buoy system includes a tail-tube buoy having a thermally insulated section disposed predominantly above a waterline, and a thermo-siphon disposed predominantly below the waterline.

Abstract: A precipitation gauge including a clear elongated outer cylinder and an opaque or translucent inner member disposed longitudinally in the outer cylinder to define a tubular water receiver in the space between the cylinder and the inner member and markings disposed along either the outer cylinder or the inner member, the gauge indicating the amount of water collected in the water receiver with a sharp demarcation at the top surface of the water resulting from an optical illusion making it appear that the portion of the gauge below the demarcation is filled with a fluid of the color of the inner member.

Abstract: Antibodies directed to human protein mismatch repair proteins can be used diagnostically to discriminate between proliferating and non-proliferating cells. In addition, they can be used to determine whether cells have a mismatch repair defect caused by a mutation in e.g., hMSH2, hMLH1, or hPMS2. They can also be used to monitor the efficacy of anti-neoplastic therapies.

Abstract: Antibodies and assays employing them are taught which are useful for detecting the bulk of mutations which occur in the APC gene in familial adenomatous polyposis. The antibodies are specific for epitopes in the amino terminal or carboxy terminal portion of the protein. A variety of immunoassay formats are described which are all based on the observation that the bulk of the APC mutations which occur in familial adenomatous polyposis and sporadic colorectal carcinomas result in truncated APC proteins. Generally, either the size of APC proteins is determined or the relative binding of amino terminal-binding antibodies to carboxy terminal-binding antibodies is determined.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.

Abstract: In certain human tumor cells, the gene encoding MDM2 protein is amplified and expression of MDM2 protein is elevated. Since human MDM2 protein binds to human p53, excess MDM2 protein apparently releases a cell from p53-regulated growth. Detection of elevated amounts of human MDM2 protein thus can be used to diagnose neoplastic disease in a human.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth. Antibodies to the human MDM2 protein and kits containing MDM2 specific antibodies are disclosed.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.

Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.

Abstract: A clipboard arrangement includes a planar base member having a raised peripheral rim and a suction cup mounting plate hingedly mounted to a top edge of the base member. A removable clipboard assembly is selectively mounted to the planar base member and has a clamp plate at its upper edge for mounting a writing pad upon the clipboard. A bottom bracket extends outwardly from the base member to cradle and hold the clipboard bottom edge and a tang and slot juncture extends between the clipboard and the planar base member toward upper portions of the clipboard and base member so that a clipboard can be easily lifted slightly upwardly and then outwardly from the base member for carrying. Use of the clipboard arrangement permits the user to semi-permanently mount the planar base member to a suitable surface within a vehicle, such as a windshield or dashboard and then to easily remove the clipboard when going about his or her business, such as shopping or running errands.