Patents by Inventor David E. Kohne

David E. Kohne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8227260
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: July 24, 2012
    Assignee: Invitrogen Corporation
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Publication number: 20100081579
    Abstract: A method for preserving a sample is described. A method for preserving a sample device such as microarrays, slides and membranes is described. The preservation is achieved by applying a coating composition to a sample or sample device, and curing the coating composition. Candidate coating materials for forming the coating compositions are described. Preferably, the coating composition is an optically clear, solidifying solution. Also described are preservation kits which provide materials and instructions for the preservation of sample devices. Calibration devices are also described.
    Type: Application
    Filed: May 20, 2009
    Publication date: April 1, 2010
    Applicant: INVITROGEN CORPORATION
    Inventors: Paul BUSHWAY, Laurence Warden, Todd Peterson, David E. Kohne, Juan Yguerabide
  • Publication number: 20100069259
    Abstract: A method for archiving sample devices such as microarray slides and membranes is described using an optically clear, solidifying solution. Also described are related methods and kits.
    Type: Application
    Filed: June 19, 2009
    Publication date: March 18, 2010
    Applicant: INVITROGEN CORPORATION
    Inventors: Paul BUSHWAY, Laurence WARDEN, Todd PETERSON, David E. KOHNE, Juan YGUERABIDE
  • Publication number: 20090253140
    Abstract: Described are methods for determining the presence or absence of particular polymorphisms in CYP2D6 and other genes using scattered light detectable particles as detectable labels, and compositions useful in such methods.
    Type: Application
    Filed: February 24, 2009
    Publication date: October 8, 2009
    Applicant: INVITROGEN CORPORATION
    Inventors: Gary Bee, David E. Kohne, Linda Korb, Todd Peterson, Juan Yguerabide
  • Publication number: 20090004757
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Application
    Filed: June 23, 2008
    Publication date: January 1, 2009
    Applicant: Invitrogen Corporation
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Patent number: 7255995
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: August 14, 2007
    Assignee: Invitrogen Corporation
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Publication number: 20030207328
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Application
    Filed: October 30, 2002
    Publication date: November 6, 2003
    Applicant: Genicon Sciences Corporation
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Publication number: 20030124733
    Abstract: A method for preserving a sample is described. A method for preserving a sample device such as microarrays, slides and membranes is described. The preservation is achieved by applying a coating composition to a sample or sample device, and curing the coating composition. Candidate coating materials for forming the coating compositions are described. Preferably, the coating composition is an optically clear, solidifying solution. Also described are preservation kits which provide materials and instructions for the preservation of sample devices. Calibration devices are also described.
    Type: Application
    Filed: September 5, 2002
    Publication date: July 3, 2003
    Applicant: Genicon Sciences Corporation
    Inventors: Paul Bushway, Laurence Warden, Todd Peterson, David E. Kohne, Juan Yguerabide
  • Patent number: 6586193
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: July 1, 2003
    Assignees: Genicon Sciences Corporation, The Regents of the University of California
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Publication number: 20030049866
    Abstract: A method for archiving sample devices such as microarray slides and membranes is described using an optically clear, solidifying solution. Also described are related methods and kits.
    Type: Application
    Filed: September 5, 2001
    Publication date: March 13, 2003
    Applicant: Genicon Sciences Corporation
    Inventors: Paul Bushway, Laurence Warden, Todd Peterson, David E. Kohne, Juan Yguerabide
  • Publication number: 20020127561
    Abstract: Described are methods for determining the presence or absence of particular polymorphisms in CYP2D6 and other genes using scattered light detectable particles as detectable labels, and compositions useful in such methods.
    Type: Application
    Filed: June 12, 2001
    Publication date: September 12, 2002
    Inventors: Gary Bee, David E. Kohne, Linda Korb, Todd Peterson, Juan Yguerabide
  • Publication number: 20020045276
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Application
    Filed: August 16, 2001
    Publication date: April 18, 2002
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Patent number: 6214560
    Abstract: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: April 10, 2001
    Assignee: Genicon Sciences Corporation
    Inventors: Juan Yguerabide, Evangelina E. Yguerabide, David E. Kohne, Jeffrey T. Jackson
  • Patent number: 5955261
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid and molecules complementary to RNA or other nucleic sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 21, 1999
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne
  • Patent number: 5932416
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 3, 1999
    Inventor: David E. Kohne
  • Patent number: 5928864
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 27, 1999
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne
  • Patent number: 5738989
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 14, 1998
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne
  • Patent number: 5738988
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family. Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 14, 1998
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne
  • Patent number: 5723597
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree of hybridization that has occurred. The method may include contacting a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: March 3, 1998
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne
  • Patent number: 5714324
    Abstract: A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category of organisms such as any member of a bacterial taxonomic Family, Genus, or Species, and previously unknown organisms. The method comprises contacting the nucleic acid of the organisms whose presence, identification and quantitation are to be determined, with a marked probe comprising nucleic acid molecules complementary to RNA or other nucleic acid sequences, of the said organism, under nucleic acid hybridization conditions, and then determining the degree or hybridization that has occurred. The method may include contacting, a sample with an enzyme-detergent mixture to make the nucleic acids of the organism or virus in a sample more readily available for hybridization.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 3, 1998
    Assignee: Gen-Probe Incorporated
    Inventor: David E. Kohne