Patents by Inventor David E. Lyons

David E. Lyons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6702144
    Abstract: A can apron comprising an indented groove cover including an outer flange and a inner flange connected by a lateral surface, the indented groove cover constructed of flexible material providing for the snap-on fitting of the can apron, a magnet, a magnet cover piece, and means for attaching the magnet cover piece to the indented groove cover.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: March 9, 2004
    Inventor: David E. Lyon
  • Patent number: 5428135
    Abstract: A method for refolding recombinant platelet-derived growth factor from a high expression host cell system, such as E. coli, is provided in accordance with the present invention. The recombinant platelet-derived growth factor is isolated from inclusion body proteins, after which the free sulfydryl groups of the reduced monomeric recombinant protein are blocked. The blocked recombinant protein can then be brought into a biologically active conformation, without interference from the formation of incorrect disulfide bonds. Once in a biologically active conformation, the recombinant platelet-derived growth factor may be unblocked to allow the desired disulfide bonds to form, thus locking the recombinant protein into a biologically active conformation. The present invention also provides a novel mixed disulfide intermediate wherein the free sulfhydryl groups of reduced recombinant platelet-derived growth factor are derivatized to a disulfide blocking agent.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: June 27, 1995
    Assignee: Amgen Inc.
    Inventors: David E. Lyons, Arlen R. Thomason
  • Patent number: 5216812
    Abstract: A knife utensil for separating shell members of a mollusk comprised of a bar member having a blade portion mounted to retaining members forming a handle and formed with an arcuate upper honed edge and a concave-shaped lower honed edge defining a point at a free end disposed between a centerline of a bar member and a point at which the upper surface meets the retaining members.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: June 8, 1993
    Inventor: David E. Lyons