Abstract: The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

Abstract: The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

Abstract: A fuel injector control valve assembly is provided that comprises a valve actuating mechanism, a cage member that is operatively connected to the valve actuating mechanism, a poppet valve member that is operatively connected to the cage member and that defines a perimeter and a longitudinal axis, a valve sleeve member that is disposed about the poppet valve member, a shim that includes an upper surface that at least partially makes uninterrupted contact with the cage member and a lower surface that at least partially makes uninterrupted contact with the sleeve member, thereby providing a fluid seal about the perimeter of the poppet valve member, and a bounce limiting mechanism that is adjacent the shim and that is interposed between the cage member and at least one of either the poppet valve member and the valve sleeve member.

Abstract: A fuel injector control valve assembly is provided that comprises a valve actuating mechanism, a cage member that is operatively connected to the valve actuating mechanism, a poppet valve member that is operatively connected to the cage member and that defines a perimeter and a longitudinal axis, a valve sleeve member that is disposed about the poppet valve member, a shim that includes an upper surface that at least partially makes uninterrupted contact with the cage member and a lower surface that at least partially makes uninterrupted contact with the sleeve member, thereby providing a fluid seal about the perimeter of the poppet valve member, and a bounce limiting mechanism that is adjacent the shim and that is interposed between the cage member and at least one of either the poppet valve member and the valve sleeve member.

Abstract: A fuel injector is disclosed. The fuel injector includes an injector valve needle and a valve actuation assembly including a stator, an armature, and a valve, the valve in fluid communication with the injector valve needle. A stator protection device is positioned between the stator and at least a portion of the armature. The stator protection device is configured to prevent contact between the stator and the armature.

Abstract: The present invention relates to crystalline polymorphs of 3-O-(3?,3?-dimethylsuccinyl)betulinic acid di-N-methyl-D-glucamine salt (“DSB•2NMG)”), pharmaceutical compositions of the same and use of the same as an active pharmaceutical agent in the treatment of HIV related disorders.

Abstract: In a Grid computer system having a plurality of download servers in network communication with client computers and a download management system, a client requests a download plan from the download management system for downloading data in parallel from the plurality of download servers to a client. The client requests chunks of data from download servers identified by the download plan. The client monitors the performance of the download servers downloading the chunks and reassigns portions of chunks amongst the download servers in order to improve the performance of completing the download of the chunks. A chunk of download data is a plurality of files, a file or a portion of file of data.

Abstract: A fuel injector is disclosed. The fuel injector includes an injector valve needle and a valve actuation assembly including a stator, an armature, and a valve, the valve in fluid communication with the injector valve needle. A stator protection device is positioned between the stator and at least a portion of the armature. The stator protection device is configured to prevent contact between the stator and the armature.

Abstract: A system and method for simulating a stress or failure in a network of a plurality of simulated networked program logic controllers includes simulating a plurality of networked program logic controllers in a network, the networked program logic controllers each having network information defining a node, the network information being selected from a type of program logic controller, an I/O connected to the program logic controller and a type of connection for the program logic controller; providing an interface in communication with each of the networked program logic controllers for simulating a network error; and activating the interface for inducing one of a stress or failure in the network.

Abstract: A pre-chiller for an ice making system. The pre-chiller provides a coiled conductive tube mounted in an ice storage bin. Water flows through the tube and is chilled by the tube that is cold as a result of heat exchange from the ice in the ice storage bin. This chilled water is then delivered to the water inlet of the refrigeration system. The lower temperature of the chilled water compared to the typical ambient temperature of the water delivered to the refrigeration system lowers the power consumption of the refrigeration system and increases its efficiency.

Abstract: A method and system is provided for creating applications for one or more types of programmable logic controllers (PLCs). A open development kit (ODK) is provided that permits dynamic link libraries to be created and interfaced to a user application software and also to the interface layers of the various types of PLCs. The types of PLCs may include soft PLCs, slot PLCs, and hard PLCs and interface via slots of a personal computer platform. The ODK provides generic interfacing to the various types of PLCs and establishes the necessary operating environment structure to implement processing in either a non-real time and a real time mode. A single application package may then control and manage the various types of PLCs. Communication paths are provided from the PLCs to the ODK subsystem to the user application so that the application software is essentially indifferent to type of PLC involved.

Abstract: A system and method for simulating a plurality of networked program logic controllers includes, in one aspect of the invention, determining if a configuration of networked program logic controllers exists; populating a configuration by creating a plurality of program logic controllers in a network if the configuration does not exist, the populating of the program logic controllers provided by use of a network view for collecting network information; and interacting with at least one of the program logic controllers to simulate a networked program logic controller.

Abstract: Dental pulp healing lining or capping compositions and methods of using the composition to treat an exposed, nearly exposed, or breached pulp chamber are disclosed herein. Embodiments include dental pulp healing lining or capping compositions comprising a resin portion having at least one hydrophilic monomer component and at least one hydrophobic monomer component and a calcareous material operable to both provide a biological seal and maintain an alkaline pH for extended periods. Further, light curable compositions are disclosed, allowing for improved curing properties, and allowing permanent restorations to be adhered to the sealed tooth without waiting a significant amount of time for the Portland cement portion to cure.

Abstract: It is becoming more common for diesel engine cylinders to include an engine compression release brake that can utilize energy built up in the cylinder to provide additional braking for the vehicle. The present invention utilizes a software diagnostic test that is stored in an electronic control module to detect defects in the engine compression release brakes. In particular, the present invention operates a first portion of the engine cylinders in a power mode and a second portion of the engine cylinders in a braking mode and compares a resulting fuel injector response or engine response to an expected value to determine if one or more of the engine compression release brakes are performing as expected.

Abstract: A control system adapted to control an actuator between extended and retracted positions has a fluid control valve connected to the actuator a source of high pressure fluid and a reservoir. The fluid control valve is movable between a first position at which the actuator is connected back to the fluid reservoir adapted and a second position operable to connect the actuator to a high pressure actuation fluid source. An electronic control module is connected in control communication with the fluid control valve and adapted to automatically generate a control signal to position the control valve at the second position in response to an elapsed time being passed at which the fluid control valve is at the first position is greater than a predetermined time.

Abstract: A method and system is provided for creating applications for one or more types of programmable logic controllers (PLCs). A open development kit (OKD) is provided that permits dynamic link libraries to be created and interfaced to a user application software and also to the interface layers of the various types of PLCs. The types of PLCs may include soft PLCs, slot PLCs, and hard PLCs and interface via slots of a personal computer platform. The ODK provides generic interfacing to the various types of PLCs and establishes the necessary operating environment structure to implement processing in either a non-real time and a real time mode. A single application package may then control and manage the various types of PLCs. Communication paths are provided from the PLCs to the ODK subsystem to the user application so that the application software is essentially indifferent to type of PLC involved.

Abstract: The invention relates to methods and devices for treating disorders with electric current or electric field therapy. The invention uses applied electric current or current induced by an external electric field to manipulate movement of ions across cell membranes and to alter ionic concentrations. The invention is useful, for example, for treating hyperproliferative and cardiovascular disorders and for ameliorating the effects of stress.

Abstract: A method and system for determining the likely uniqueness and novelty of a subject concept, such as a patent, in comparison with other published references embodying other concepts by examining the subject concept in the context of references published both before and after the subject concept looking for instances in which a particular other published reference can be determined to be an ancestor of or progeny of the subject concept and then constructing and displaying a morphogenetic icon for representing such multi-dimensional, multi-temporal relationships in a two-dimensional manner.

Abstract: The present invention is an encapsulated yeast composite comprising a core comprising yeast and a coating which comprises a low melting point lipid which melts at a temperature not greater than 95° F. The yeast includes Saccharomyces cerevisiae. The encapsulated composites are useful in the production of food compositions and food products.