Abstract: A ureteral catheter is provided, including a drainage lumen including a proximal portion and a distal portion configured to be positioned in a patient's kidney, renal pelvis, and/or in the ureter adjacent to the renal pelvis, the distal portion including a retention portion for maintaining positioning of the distal portion of the drainage lumen, the retention portion including at least two openings on a sidewall of the retention portion for permitting fluid flow into the drainage lumen wherein a total area of a proximal most opening of the at least two openings is less than a total area of more distal opening(s) nearer to the distal end of the drainage lumen, and wherein when negative pressure is applied through the ureteral catheter, fluid is drawn into the ureteral catheter through the at least two openings.

Abstract: A ureteral catheter includes a drainage lumen having a proximal portion configured to be positioned in at least a portion of a patient's urethra and/or bladder and a distal portion configured to be positioned in a patient's kidney, renal pelvis, and/or in the ureter adjacent to the renal pelvis. The distal portion includes a retention portion for maintaining positioning of the distal portion of the drainage lumen. The retention portion includes a plurality of sections, each section having one or more openings on a sidewall of the retention portion for permitting fluid flow into the drainage lumen. A total area of openings of a first section of the plurality of sections is less than a total area of openings of an adjacent second section of the plurality of sections. The second section is closer to a distal end of the drainage lumen than the first section.

Abstract: A catheter includes an elongated tube having a distal portion having a distal end and a sidewall defining at least one drainage lumen. The catheter also includes a permeable material. The permeable material is configured to be deployed in the urinary tract to maintain the distal end of the elongated tube at a predetermined position in a bladder, a ureter, a renal pelvis, or a kidney of the patient. When deployed, the permeable material defines a three-dimensional shape of sufficient size to permit flow of at least a portion of fluid from the urinary tract through the permeable material and the at least one drainage lumen.

Abstract: A catheter includes an elongated tube having a distal portion having a distal end and a sidewall defining at least one drainage lumen. The sidewall includes a drainage portion which allows fluid to pass through the sidewall and into the drainage lumen. The catheter also includes a permeable tissue support. The tissue support is configured to be deployed in the urinary tract to maintain the distal end of the elongated tube at a predetermined position in a bladder, a ureter, a renal pelvis, or a kidney of the patient. When deployed, the permeable tissue support defines a three-dimensional shape of sufficient size to permit flow of at least a portion of fluid from the urinary tract through the tissue support and drainage portion of the elongated tube to the at least one drainage lumen.

Abstract: A method is provided for facilitating urine output from the kidney, including: (a) inserting a catheter including: a drainage lumen including a distal portion configured to be positioned in a patient's kidney, renal pelvis and/or in the ureter adjacent to the renal pelvis and a proximal portion, the distal portion including a retention portion including a funnel support including at least one sidewall, wherein the funnel support includes a first diameter and a second diameter, the first diameter being less than the second diameter, the second diameter being closer to an end of the distal portion of the drainage lumen than the first diameter, wherein the proximal portion of the drainage lumen is essentially free of or free of openings; and (b) applying negative pressure to the proximal portion of the drainage lumen for a period of time to facilitate urine output from the kidney.

Abstract: Ureteral or bladder catheters are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion that includes one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon application of negative pressure through the catheter. Systems, kits and methods for inducing negative pressure to increase renal function also are provided.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: A method is provided for facilitating urine output from the kidney, including: (a) inserting a catheter including: a drainage lumen including a distal portion configured to be positioned in a patient's kidney, renal pelvis and/or in the ureter adjacent to the renal pelvis and a proximal portion, the distal portion including a retention portion including a funnel support including at least one sidewall, wherein the funnel support includes a first diameter and a second diameter, the first diameter being less than the second diameter, the second diameter being closer to an end of the distal portion of the drainage lumen than the first diameter, wherein the proximal portion of the drainage lumen is essentially free of or free of openings; and (b) applying negative pressure to the proximal portion of the drainage lumen for a period of time to facilitate urine output from the kidney.

Abstract: A pump assembly for increasing urine output from a patient includes at least one ureteral catheter including: a distal portion having a retention portion configured to be positioned in a patient's kidney, renal pelvis, and/or ureter; and a proximal portion defining a drainage lumen. The retention portion includes at least one drainage port which permits fluid flow into the drainage lumen. The pump assembly further includes a pump configured to provide negative pressure to at least one of the renal pelvis or kidney through the drainage lumen of the at least one ureteral catheter. The pump includes at least one fluid port in fluid communication with the drainage lumen of the proximal portion of the ureteral catheter for receiving fluid from the patient's kidney, wherein at least a portion of the pump is configured to be positioned within a patient's body.

Abstract: A method for increasing urine output rate from a patient having venous congestion is provided. The method includes: deploying a urinary catheter into the patient such that flow of urine from the ureter and/or kidney is transported within a drainage lumen of the catheter; applying negative pressure to the ureter and/or kidney through the drainage lumen of the catheter to extract urine from the patient; periodically measuring an edema value of the patient; and if the measured edema value is less than or equal to Grade 1 in which the depth of indentation is less than about 2 mm after about 10 seconds, ceasing the application of the negative pressure to the ureter and/or kidney.

Abstract: Ureteral or bladder catheters and systems are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion including an outer periphery or protective surface area which prevents mucosal tissue from occluding one or more protected drainage holes, ports, or perforations disposed within the outer periphery or protective surface area upon application of negative pressure through the catheter.

Abstract: A ureteral catheter includes a drainage lumen having a proximal portion configured to be positioned in at least a portion of a patient's urethra and/or bladder and a distal portion configured to be positioned in a patient's kidney, renal pelvis, and/or in the ureter adjacent to the renal pelvis. The distal portion includes a retention portion for maintaining positioning of the distal portion of the drainage lumen. The retention portion includes a plurality of sections, each section having one or more openings on a sidewall of the retention portion for permitting fluid flow into the drainage lumen. A total area of openings of a first section of the plurality of sections is less than a total area of openings of an adjacent second section of the plurality of sections. The second section is closer to a distal end of the drainage lumen than the first section.

Abstract: A pump assembly is provided, including a pump module configured to be positioned within an interior portion of a ureter and/or renal pelvis of a patient for providing negative pressure to the patient's ureter and/or kidney, the pump module including: a housing including a flow channel for conducting fluid, wherein the housing is configured to be positioned within the interior portion of the ureter and/the renal pelvis; and a pump element positioned within the channel to draw fluid through the channel; and a control module coupled to the pump module, the control module being configured to direct motion of the pump element to control flow rate of fluid passing through the channel, and including a housing configured to be positioned within at least one of a second interior portion of the patient's ureter, a second portion of the patient's renal pelvis, or an interior portion of a patient's bladder.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Disclosed herein are bioreactor systems and methods of utilizing said systems.

Abstract: A method for removing excess fluid from a patient with hemodilution is provided. The method includes: deploying a urinary tract catheter into the patient such that flow of urine from the ureter and/or kidney is transported within a drainage lumen of the catheter; applying negative pressure to the ureter and/or kidney through the drainage lumen of the catheter to extract urine from the patient; periodically measuring a hematocrit value of the patient; and if the measured hematocrit value is greater than a predetermined threshold value, ceasing the application of the negative pressure to the ureter and/or kidney. A system for removing excess fluid from a patient with hemodilution including a ureteral catheter and a pump is also provided.