Patents by Inventor David E. Pereira

David E. Pereira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS
    Publication number: 20190328759
    Abstract: Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods for their use in the treatment of bacterial, protozoal, and other infections are described herein.
    Type: Application
    Filed: November 30, 2018
    Publication date: October 31, 2019
    Inventors: David E. PEREIRA, Sara WU, Prabhavathi FERNANDES
  • Parenteral formulations for administering macrolide antibiotics
    Patent number: 10188674
    Abstract: Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods for their use in the treatment of bacterial, protozoal, and other infections are described herein.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: January 29, 2019
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventors: David E. Pereira, Sara Wu, Prabhavathi Fernandes
  • Compounds and methods for treating inflammatory diseases
    Patent number: 9937194
    Abstract: Described herein are compounds and pharmaceutical compositions useful for treating inflammatory diseases.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: April 10, 2018
    Assignee: Cempra Pharmaceuticals, Inc.
    Inventors: Prabhavathi Fernandes, David E. Pereira
  • Methods for treating resistant diseases using triazole containing macrolides
    Patent number: 9901592
    Abstract: Described herein are macrolide and ketolide antibiotics and pharmaceutical compositions, methods, and uses thereof for treating diseases caused at least in party by resistant bacteria.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: February 27, 2018
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventors: Prabhavathi Fernandes, David E. Pereira
  • Hydrogen bond forming fluoro ketolides for treating diseases
    Patent number: 9815863
    Abstract: The invention described herein pertains to a novel macrolide antibacterial agent of formula (I): A-L-Q, as defined herein, and pharmaceutically acceptable salts, solvates, and hydrates thereof. Inter alia, the new macrolide antibacterial agent is active against a number of bacterial species, including resistant species.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: November 14, 2017
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventor: David E. Pereira
  • Process for the preparation of macrolide antibacterial agents
    Patent number: 9453042
    Abstract: Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: September 27, 2016
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventors: David E. Pereira, Manish Kanchanbhai Patel, Keshav Deo
  • PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS
    Publication number: 20150342977
    Abstract: Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods for their use in the treatment of bacterial, protozoal, and other infections are described herein.
    Type: Application
    Filed: March 27, 2013
    Publication date: December 3, 2015
    Inventors: David E. PEREIRA, Sara WU, Prabhavathi FERNANDES
  • PROCESSES FOR PREPARING MACROLIDES AND KETOLIDES AND INTERMEDIATES THEREFOR
    Publication number: 20150232500
    Abstract: The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventor: David E. Pereira
  • Process for preparing triazole-containing ketolide antibiotics
    Patent number: 9051346
    Abstract: The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: June 9, 2015
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventor: David E. Pereira
  • METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES
    Publication number: 20150105339
    Abstract: Described herein are macrolide and ketolide antibiotics and pharmaceutical compositions, methods, and uses thereof for treating diseases caused at least in party by resistant bacteria.
    Type: Application
    Filed: June 19, 2014
    Publication date: April 16, 2015
    Inventors: Prabhavathi FERNANDES, David E. Pereira
  • Crystalline forms of a macrolide, and uses therefor
    Patent number: 8975386
    Abstract: New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the crystalline forms are described herein.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 10, 2015
    Assignee: Cempra Pharmaceuticals, Inc.
    Inventor: David E. Pereira
  • Methods for treating resistant diseases using triazole containing macrolides
    Patent number: 8796232
    Abstract: Triazole-containing macrolide and ketolide antibiotics, therapeutic compositions containing them and methods of use for treating diseases caused by one or more resistant organisms are described.
    Type: Grant
    Filed: October 24, 2009
    Date of Patent: August 5, 2014
    Assignee: Cempra Pharmaceuticals, Inc.
    Inventors: Prabhavathi B. Fernandes, David E. Pereira
  • Crystalline forms of a macrolide, and uses therefor
    Patent number: 8759500
    Abstract: New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the crystalline forms are described herein.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: June 24, 2014
    Assignee: Cempra Pharmaceuticals, Inc.
    Inventor: David E. Pereira
  • COMPOSITIONS COMPRISING FUSIDIC ACID AND PACKAGES THEREFOR
    Publication number: 20140088062
    Abstract: Described are solid pharmaceutical compositions of fusidic acid, and pharmaceutically acceptable salts thereof, dosage units of the pharmaceutical compositions, and packages for pharmaceutical compositions of fusidic acid, and pharmaceutically acceptable salts thereof, which increase stability against the degradation of the fusidic acid, and pharmaceutically acceptable salts thereof. Also described are uses of the pharmaceutical compositions and dosage units in treating diseases.
    Type: Application
    Filed: May 23, 2012
    Publication date: March 27, 2014
    Applicant: CEM-102 PHARMACEUTICALS, INC.
    Inventor: David E. Pereira
  • Ruthenium (II) catalysts for use in stereoselective cyclopropanations
    Patent number: 8558017
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran,deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 15, 2013
    Assignee: Vanda Pharmaceuticals, Inc.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger
  • CRYSTALLINE FORMS OF A MACROLIDE, AND USES THEREFOR
    Publication number: 20130252915
    Abstract: New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the crystalline forms are described herein.
    Type: Application
    Filed: May 22, 2013
    Publication date: September 26, 2013
    Applicant: Cempra Pharmaceuticals, Inc.
    Inventor: David E. PEREIRA
  • HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES
    Publication number: 20130172280
    Abstract: The invention described herein pertains to a novel macrolide antibacterial agent of formula (I): A-L-Q, as defined herein, and pharmaceutically acceptable salts, solvates, and hydrates thereof. Inter alia, the new macrolide antibacterial agent is active against a number of bacterial species, including resistant species.
    Type: Application
    Filed: September 9, 2011
    Publication date: July 4, 2013
    Applicant: CEMPRA PHARMACEUTICALS, INC.
    Inventor: David E. Pereira
  • PROCESS FOR PREPARING TRIAZOLE-CONTAINING KETOLIDE ANTIBIOTICS
    Publication number: 20130066056
    Abstract: The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.
    Type: Application
    Filed: May 20, 2011
    Publication date: March 14, 2013
    Applicant: CEMPRA PHARMACEUTICALS, INC.
    Inventor: David E. Pereira
  • PARENTERAL FORMULATIONS OF MACROLIDE ANTIBIOTICS
    Publication number: 20130045937
    Abstract: Described herein are pharmaceutical compositions adapted for the parenteral administration of macrolide antibiotics, such as triazole-containing and fluoroketolide antibiotics. Also described herein are methods for their use in the treatment of bacterial, protozoal, and other infections.
    Type: Application
    Filed: March 10, 2011
    Publication date: February 21, 2013
    Applicant: CEMPRA PHARMACEUTICALS, INC.
    Inventors: David E. Pereira, Prabhavathi Fernandes
  • RUTHENIUM (II) CATALYSTS FOR USE IN STEREOSELECTIVE CYCLOPROPANATIONS
    Publication number: 20130023662
    Abstract: Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is prepared in situ by combining an alkenyl ligand, a deprotonated chiral salen ligand, and a ruthenium (II) metal. A preferred catalyst is prepared in situ by combining 2,3-dihydro-4-venylbenzofuran, deprotonated 1,2-cyclohexanediamino-N,N?-bis(3,5-di-t-butyl-salicylidene) and RuCl2(p-cymene)]2.
    Type: Application
    Filed: December 12, 2011
    Publication date: January 24, 2013
    Applicant: VANDA PHARMECEUTICALS INC.
    Inventors: David E. Pereira, Wade Aumiller, Raymond Dagger