Patents by Inventor David E. Podhorez

David E. Podhorez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210198262
    Abstract: The present disclosure concerns a method for preparing florasulam which involves treating a solution of 2,6-difluoroaniline in 1,2-propylene glycol with: a) sulfonyl chloride III and then b) a base to provide, after workup and isolation, florasulam (I) in yields of about 65-85%. The treatment of 2,6-difluoroaniline with sulfonyl chloride III and the base are conducted by controlled additions.
    Type: Application
    Filed: October 10, 2018
    Publication date: July 1, 2021
    Applicant: Dow AgroSciences LLC
    Inventors: Jossian Oppenheimer, Michael Gullo, David E. Podhorez, Justin A. Alberts
  • Publication number: 20190106428
    Abstract: The present disclosure concerns a method for preparing florasulam which involves treating a solution of 2,6-difluoroaniline in 1,2-propylene glycol with: a) sulfonyl chloride III and then b) a base to provide, after workup and isolation, florasulam (I) in yields of about 65-85%. The treatment of 2,6-difluoroaniline with sulfonyl chloride III and the base are conducted by controlled additions.
    Type: Application
    Filed: October 10, 2018
    Publication date: April 11, 2019
    Applicant: Dow AgroSciences LLC
    Inventors: Jossian Oppenheimer, Michael Gullo, David E. Podhorez, Justin A. Alberts
  • Patent number: 10233155
    Abstract: This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers. Further, the present application relates to certain novel compounds useful in the preparation of pesticidal thioethers. Specifically, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof. More particularly, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof by halogenating and reducing 4-nitropyrazole.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: March 19, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Erich J. Molitor, Mark Muehlfeld, Joseck M. Muhuhi, Patrick T. McGough, Gary Roth, David E. Podhorez, Christopher W. Derstine, Stacie L. Santhany
  • Publication number: 20180282298
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 4, 2018
    Inventors: Qiang YANG, Beth Lorsbach, David E. Podhorez
  • Publication number: 20180186750
    Abstract: This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers. Further, the present application relates to certain novel compounds useful in the preparation of pesticidal thioethers. Specifically, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof. More particularly, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof by halogenating and reducing 4-nitropyrazole.
    Type: Application
    Filed: December 22, 2017
    Publication date: July 5, 2018
    Inventors: Erich J. MOLITOR, Mark MUEHLFELD, Joseck M. MUHUHI, Patrick T. MCGOUGH, Gary ROTH, David E. PODHOREZ, Christopher W. DERSTINE, Stacie L. SANTHANY
  • Patent number: 10005758
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: June 26, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, David E. Podhorez
  • Publication number: 20180044319
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Application
    Filed: October 24, 2017
    Publication date: February 15, 2018
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Daniel I. Knueppel, Ann M. Buysse, Kaitlyn Gray, Xiaoyong Li, Joseck M. Muhuhi, Ronald Ross, JR., David E. Podhorez, Yu Zhang
  • Publication number: 20180037565
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Application
    Filed: October 13, 2017
    Publication date: February 8, 2018
    Inventors: Qiang YANG, Beth LORSBACH, David E. PODHOREZ
  • Patent number: 9809570
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-•dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: November 7, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, David E. Podhorez
  • Publication number: 20170101392
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Application
    Filed: December 23, 2016
    Publication date: April 13, 2017
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Daniel I. Knueppel, Ann M. Buysse, Kaitlyn Gray, Xiaoyong Li, Joseck M. Muhuhi, Ronald Ross, JR., David E. Podhorez, Yu Zhang
  • Patent number: 9611247
    Abstract: 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-·dihydrochloride with acrylonitrile to provide 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine, by oxidizing to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 4, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, Xiaoyong Li, Gary Roth, David E. Podhorez
  • Patent number: 9580405
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 28, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Daniel I. Knueppel, Ann M. Buysse, Kaitlyn Gray, Xiaoyong Li, Joseck M. Muhuhi, Ronald Ross, Jr., David E. Podhorez, Yu Zhang
  • Publication number: 20170044134
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 16, 2017
    Inventors: Qiang YANG, Beth LORSBACH, David E. PODHOREZ
  • Patent number: 9522900
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1 -(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: December 20, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, David E. Podhorez
  • Publication number: 20160272615
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Application
    Filed: May 27, 2016
    Publication date: September 22, 2016
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Daniel I. Knueppel, Ann M. Buysse, Kaitlyn Gray, Xiaoyong Li, Joseck M. Muhuhi, Ronald Ross, JR., David E. Podhorez, Yu Zhang
  • Patent number: 9414594
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: August 16, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Qiang Yang, Beth Lorsbach, Gregory Whiteker, Gary Roth, Carl DeAmicis, Daniel I. Knueppel, Ann M. Buysse, Kaitlyn Gray, Xiaoyong Li, Joseck M. Muhuhi, Ronald Ross, Jr., David E. Podhorez, Yu Zhang
  • Patent number: 9376388
    Abstract: Provided herein are fluoropicolinoyl fluorides and processes for their preparation. In some embodiments, provided herein is a process for the preparation of 5-fluoro-6-aryl-picolinoyl fluorides from chloropicolinoyl chlorides.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 28, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: James M. Renga, Yang Cheng, Joseck M. Muhuhi, David E. Podhorez, Gary A. Roth, Scott P. West, Gregory T. Whiteker, Yuanming Zhu
  • Publication number: 20160052908
    Abstract: 3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.
    Type: Application
    Filed: July 28, 2015
    Publication date: February 25, 2016
    Inventors: Qiang YANG, Beth LORSBACH, David E. PODHOREZ
  • Publication number: 20160031850
    Abstract: 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with acrylonitrile to provide 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine, by oxidizing to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.
    Type: Application
    Filed: September 9, 2015
    Publication date: February 4, 2016
    Inventors: Qiang YANG, Beth LORSBACH, Xiaoyong LI, Gary ROTH, David E. PODHOREZ
  • Patent number: 9249122
    Abstract: 3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine•dihydrochloride with acrylonitrile to provide 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine, by oxidizing to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: February 2, 2016
    Inventors: Qiang Yang, Beth Lorsbach, Xiaoyong Li, Gary Roth, David E. Podhorez