Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: The technology described in this document can be embodied in a method of using a silver-zinc rechargeable battery to power a device. The method includes drawing, in a first mode of operation of a power management circuit, a first current from the battery to power the device. The first current is selected such that a target percentage of a capacity of the battery is discharged in a predetermined time of use of the device. The method also includes switching to a second mode of operation after the target percentage of the capacity of the battery is discharged. In the second mode of operation, a second current is drawn from the battery, wherein the second current is less than the first current. The method further includes powering the device using the second current.

Abstract: The technology described in this document can be embodied in a method of using a silver-zinc rechargeable battery to power a device. The method includes drawing, in a first mode of operation of a power management circuit, a first current from the battery to power the device. The first current is selected such that a target percentage of a capacity of the battery is discharged in a predetermined time of use of the device. The method also includes switching to a second mode of operation after the target percentage of the capacity of the battery is discharged. In the second mode of operation, a second current is drawn from the battery, wherein the second current is less than the first current. The method further includes powering the device using the second current.

Abstract: The technology described in this document can be embodied in a method of using a silver-zinc rechargeable battery to power a device. The method includes drawing, in a first mode of operation of a power management circuit, a first current from the battery to power the device. The first current is selected such that a target percentage of a capacity of the battery is discharged in a predetermined time of use of the device. The method also includes switching to a second mode of operation after the target percentage of the capacity of the battery is discharged. In the second mode of operation, a second current is drawn from the battery, wherein the second current is less than the first current. The method further includes powering the device using the second current.

Abstract: A hinge assembly for attaching a hood to a body of a vehicle includes a body-side bracket fixedly attached to the body and a hood-side bracket fixedly attached to the hood. A pivot mechanism is configured to place the hinge assembly in: a stowed position, in which the hood is adjacent the body; an access position, in which the hood rotates toward a rear of the vehicle; and an active position, in which the hood rotates toward a front of the vehicle. The hinge assembly also includes an actuator that configured to move the pivot mechanism to, or toward, the active position. A pin is attached to the body-side bracket and an upstop link is attached to the hood-side bracket. The upstop link defines a slot. The pin becomes engaged with the slot when the pivot mechanism is in the active position.

Abstract: The invention provides systems, and methods of using the systems, implementing a benefit product with a guaranteed minimum income, wherein payment into the benefit product securing the guaranteed minimum income. The system comprises an income recordkeeper interfacing with a plurality of savings recordkeepers, the income recordkeeper including (1) an income recordkeeper interface portion that inputs attributes to the benefit product funded by payments from a plan associated with the benefit product; and (2) an income recordkeeper record keeping system that implements the benefit product, the income recordkeeper record keeping system being in communication with the income recordkeeper interface portion, the income recordkeeper record keeping system: (a) monitoring transactions to the benefit product; and (b) determining, based on the transactions, a guaranteed minimum income associated with participation in the benefit product.

Abstract: A hinge assembly for attaching a hood to a body of a vehicle includes a body-side bracket fixedly attached to the body and a hood-side bracket fixedly attached to the hood. A pivot mechanism is configured to place the hinge assembly in: a stowed position, in which the hood is adjacent the body; an access position, in which the hood rotates toward a rear of the vehicle; and an active position, in which the hood rotates toward a front of the vehicle. The hinge assembly also includes an actuator that configured to move the pivot mechanism to, or toward, the active position. A pin is attached to the body-side bracket and an upstop link is attached to the hood-side bracket. The upstop link defines a slot. The pin becomes engaged with the slot when the pivot mechanism is in the active position.

Abstract: A method for installing a self-clinching fastener in a metal substrate includes receiving the substrate in a shape-forming press, the substrate being substantially hotter than the press; operating the press to shape the substrate, the substrate having a transitioning hardness while cooling in the press; and installing the fastener in the substrate during the transitioning.

Abstract: A fastener includes a nut having an anterior portion, a posterior portion and a threaded bore with a center axis extending from the anterior portion to the posterior portion, the outer surface of the posterior portion having an annular camming surface concentric with the center axis, the camming surface having a radius that decreases along the direction of the center axis away from the anterior portion toward the posterior portion; and a sleeve having a first end having an internal annular camming surface that engages the nut camming surface concentrically with the center axis and a second end having a thrusting surface. Tightening the fastener on an externally threaded member applies a force to the thrusting surface parallel to the center axis resulting in the nut camming surface and the sleeve camming surface cooperating to compress a portion of the threaded bore toward the threaded member.

Abstract: The invention provides systems, and methods of using the systems, implementing a benefit product with a guaranteed minimum income, wherein payment into the benefit product securing the guaranteed minimum income. The system comprises an income recordkeeper interfacing with a plurality of savings recordkeepers, the income recordkeeper including (1) an income recordkeeper interface portion that inputs attributes to the benefit product funded by payments from a plan associated with the benefit product; and (2) an income recordkeeper record keeping system that implements the benefit product, the income recordkeeper record keeping system being in communication with the income recordkeeper interface portion, the income recordkeeper record keeping system: (a) monitoring transactions to the benefit product; and (b) determining, based on the transactions, a guaranteed minimum income associated with participation in the benefit product.

Abstract: The invention provides systems, and methods of using the systems, implementing a benefit product with a guaranteed minimum income, wherein payment into the benefit product securing the guaranteed minimum income. The system comprises an income recordkeeper interfacing with a plurality of savings recordkeepers, the income recordkeeper including (1) an income recordkeeper interface portion that inputs attributes to the benefit product funded by payments from a plan associated with the benefit product; and (2) an income recordkeeper record keeping system that implements the benefit product, the income recordkeeper record keeping system being in communication with the income recordkeeper interface portion, the income recordkeeper record keeping system: (a) monitoring transactions to the benefit product; and (b) determining, based on the transactions, a guaranteed minimum income associated with participation in the benefit product.

Abstract: A fastener includes a nut having an anterior portion, a posterior portion and a threaded bore with a center axis extending from the anterior portion to the posterior portion, the outer surface of the posterior portion having an annular camming surface concentric with the center axis, the camming surface having a radius that decreases along the direction of the center axis away from the anterior portion toward the posterior portion; and a sleeve having a first end having an internal annular camming surface that engages the nut camming surface concentrically with the center axis and a second end having a thrusting surface. Tightening the fastener on an externally threaded member applies a force to the thrusting surface parallel to the center axis resulting in the nut camming surface and the sleeve camming surface cooperating to compress a portion of the threaded bore toward the threaded member.

Abstract: A hood hinge assembly is provided for operatively attaching a hood to a vehicle. The assembly includes a base link configured to be coupled to the vehicle; a deploy link coupled to the base link; and a hood link coupled to the deploy link and configured to be coupled to the hood. In a first transition from a first position into a second position, the base link and the deploy link pivot with one another relative to the base link, and, in a second transition from the first position into a third position, the hood link pivots relative to the deploy link.

Abstract: The invention provides systems, and methods of using the systems, for implementing a benefit product with a guaranteed minimum income. Payment into the benefit product secures the guaranteed minimum income for a payout phase following an accumulation phase of the benefit product. The system comprises an income recordkeeper interfacing with a plurality of savings recordkeepers. The income recordkeeper includes (1) an income recordkeeper interface portion that inputs attributes to the benefit product funded by payments from a plan associated with the benefit product; and (2) an income recordkeeper record keeping system that implements the benefit product. The income recordkeeper record keeping system: (a) monitors transactions to or from the benefit product; and (b) determines, based on the transactions, a guaranteed minimum income associated with participation in the benefit product, the guaranteed minimum income being an amount that may be paid from the benefit product beginning on a future start date.

Abstract: A catalog for storing externally defined graphic element (EDGE) definitions allows graphics developers and system designers to share customized and application-specific operator interface graphics. The catalog includes publishing functionality that allows a user to submit new graphic element definitions to the catalog together with instructions regarding how the graphic element definition is to be classified within a browsable hierarchy of industry-specific categories. Search and retrieval functionality allows an HMI developer to search for desired graphic element definitions using keyword-based searching or by browsing the classification hierarchy. Advanced search functions can generate or refine search criteria based on characterizing information polled from one or more of an operator interface application, an industrial control program, or networked field devices.

Abstract: A hood hinge assembly is provided for operatively attaching a hood to a vehicle. The assembly includes a base link configured to be coupled to the vehicle; a deploy link coupled to the base link; and a hood link coupled to the deploy link and configured to be coupled to the hood. In a first transition from a first position into a second position, the base link and the deploy link pivot with one another relative to the base link, and, in a second transition from the first position into a third position, the hood link pivots relative to the deploy link.

Abstract: An device including a fastener. In some embodiments, the device is an electronic device that includes a circuit board, a support structure, and a resilient conductive clip. The circuit board may include a slot extending between opposite faces. The resilient conductive clip may couple to the support structure and be removably inserted through the slot so that it is disposed at least partially about the opposite faces. The resilient conductive clip may include lower and upper grounding portions engaged against the opposite faces of the circuit board.

Abstract: A gooseneck hinge assembly for a closure of a vehicle includes a body side strap adapted to be connected to a vehicle body of the vehicle and a closure side strap having a gooseneck shape adapted to be connected to a closure for closing an aperture in the vehicle body. The gooseneck hinge assembly also includes a pivot pin to pivotally connect the closure side strap to the body side strap to allow rotational movement therebetween. The gooseneck hinge assembly further includes a spring interconnecting the body side strap and the closure side strap to counterbalance a weight of the closure when opening and closing the aperture.

Abstract: A method and apparatus for improving the resolution of fundus images and correction of optical aberrations is described in which a bundle of electromagnetic beams is directed into an optical system and the reflected electromagnetic beams are recorded by a sensor. A processor may control the energy source to provide a plurality of different electromagnetic bundles to image the entire optical system. The reflected electromagnetic beams recorded by the sensor are compared to the original electromagnetic bundle configurations to calculate the aberrations of the optical system of interest. Among other applications, the calculated aberrations may be used to construct accurate fundus images, provide input for laser surgery of the eye, fabricate corrective lenses and provide accurate digital images of structures sensed through imperfect optical systems.

Abstract: The installing of components into an industrial computer observes a pulling paradigm in which a required resource list associated with each component is reviewed against resources in the target-industrial control device. Missing resources are obtained through a searching process that may include but is not limited to the media holding or associated with the installed component. This approach allows compatibility between different versions of the resources to be evaluated with the possibility of coexisting different version numbers being, or one version replacing the other for automatic upgrade. Collecting the resources in a available resource table allows more complete information to be provided to the user in the event the resource cannot be found and allows more complete removal of components by making an explicit attribution of ownership of each resource to one or more installed components.