Patents by Inventor David E Volk

David E Volk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of X-aptamer generation and compositions thereof
    Patent number: 9988623
    Abstract: Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: June 5, 2018
    Assignees: AM Biotechnologies, LLC, Board of Regents of the University of Texas System
    Inventors: David G Gorenstein, Weiguo He, David E Volk, Miguel-Angel Elizondo-Riojas, Ross Durland, Johnnie Engelhardt
  • METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF
    Publication number: 20140100120
    Abstract: Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 10, 2014
    Inventors: David G Gorenstein, Weiguo He, David E Volk, Miquel-Angel Elizondo-Riojas, Ross Durland, Johnnie Engelhardt