Abstract: Methods of treatment of progressive supranuclear palsy or its symptoms, with PPAR? agonists, and in particular, the compound of formula (I) known as INT131: . Also provided are methods of treating a subject that include selecting a subject having an elevated level of neurofilament light chain protein in a sample obtained from the subject, as compared to a reference level of neurofilament light chain protein, and administering a pharmaceutical composition including a therapeutically effective amount of a compound of formula (I) to the selected subject.

Abstract: Methods of treatment of progressive supranuclear palsy or its symptoms, with PPAR? agonists, and in particular, the compound of formula (I) known as INT 131: Formula (I). Also provided are methods of treating a subject that include selecting a subject having an elevated level of neurofilament light chain protein in a sample obtained from the subject, as compared to a reference level of neurofilament light chain protein, and administering a pharmaceutical composition including a therapeutically effective amount of a compound of formula (I) to the selected subject.

Abstract: Methods of treatment of progressive supranuclear palsy or its symptoms, with PPAR? agonists, and in particular, the compound of formula (I) known as INT 131: Formula (I). Also provided are methods of treating a subject that include selecting a subject having an elevated level of neurofilament light chain protein in a sample obtained from the subject, as compared to a reference level of neurofilament light chain protein, and administering a pharmaceutical composition including a therapeutically effective amount of a compound of formula (I) to the selected subject.

Abstract: A new use is provided for small molecule inhibitors of Oct4 and Sox 2 as a cellular reprogramming agent and a method of reprogramming adult mammalian somatic cells into stem-like cells is provided, using small molecule inhibitors of Oct4 and Sox 2 without the need of any material derived from embryos or fetuses, and without the need of potentially harmful transfecting vectors. Stem-like cells created by the present invention can be induced to differentiate into terminally differentiated adult somatic cells, such as, for example, neuronal cells.

Abstract: A new use is provided for small molecule inhibitors of Oct4 and Sox 2 as a cellular reprogramming agent and a method of reprogramming adult mammalian somatic cells into stem-like cells is provided, using small molecule inhibitors of Oct4 and Sox 2 without the need of any material derived from embryos or fetuses, and without the need of potentially harmful transfecting vectors. Stem-like cells created by the present invention can be induced to differentiate into terminally differentiated adult somatic cells, such as, for example, neuronal cells.

Abstract: The present invention provides a use and method for GM284 to promote the regeneration of a bodily structure comprised of a composite tissue in a subject. Additionally, the present invention provides a use and method for GM284 to promote composite tissue regeneration in a subject. The present invention further provides a use and method for GM284 to promote the regeneration of cells of a composite tissue in a subject. Finally, the present invention provides a use and method for GM284 to treat an injury to a composite tissue in a subject in need of such treatment.

Abstract: The present invention provides a use and method for GM284 to promote the regeneration of a bodily structure, comprised of a composite tissue in a subject. Additionally, the present invention provides a use and method for GM284 to promote composite tissue regeneration in a subject. The present invention further provides a use and method for GM284 to promote the regeneration of cells of a composite tissue in a subject. Finally, the present invention provides a use and method for GM284 to treat an injury to a composite tissue in a subject in need of such treatment.

Abstract: The present invention provides a method for promoting myocardial regeneration in a subject. Additionally, the present invention provides a method for promoting myocardial cell and tissue regeneration in a subject. The present invention is further directed to the use of GM-284 in promoting myocardial tissue regeneration in a subject. Finally, the present invention provides a method for treating a myocardial infarction in a subject in need of such treatment.

Abstract: The present invention provides methods for promoting healing of a wound in a and for promoting regeneration of epithelial tissue in a subject comprising administering an effective amount of 2,2?-(1,3,4-oxadiazole-2,5-diyl)bis[1-(3,3-dimethyl-1,2-dioxopentyl)-pyrrolidine (GM-284).

Abstract: The present invention provides methods for enhancing regeneration or remyelination, and for inducing hypermyelination, of neurites in damaged nervous tissue. Additionally, the present invention provides a method for modulating gene expression in Schwann cells. The present invention is further directed to uses of immunophilin ligands to enhance regeneration or remyelination of neurites in damaged nervous tissue, to induce hypermyelination of neurites in damaged nervous tissue, and to modulate gene expression in Schwann cells. Also provided is a pharmaceutical composition, comprising GM-284 and a pharmaceutically acceptable carrier. The present invention is also directed to methods for treating a peripheral neuropathy in a subject in need of treatment. Finally, the present invention provides a use of GM-284 to treat a peripheral neuropathy in a subject in need of treatment.

Abstract: The present invention provides methods for promoting healing of a wound in a subject. Additionally, the present invention provides method for promoting regeneration of epithelial tissue in a subject. The present invention is further directed to uses of immunophilin ligands in promoting healing of a wound in a subject and in promoting regeneration of epithelial tissue in a subject. Also provided are methods for enhancing epithelial cell proliferation. The present invention is also directed to methods for modulating gene expression in an epithelial cell. Finally, the present invention provides methods for treating a keratinocyte-associated disorder in a subject in need of treatment.

Abstract: This invention relates to a method of regenerating nervous tissue by contacting the tissue with Schwann cells that express &Dgr;SCIP. The inventors have demonstrated herein that Schwann cells expressing &Dgr;SCIP induce regeneration of nervous tissue. Also provided by the present invention is a method for treating a subject in need of nervous tissue regeneration by introducing Schwann cells expressing &Dgr;SCIP into the subject.

Abstract: This invention relates to a method of regenerating nervous tissue by contacting the tissue with Schwann cells that express &Dgr;SCIP. The inventors have demonstrated herein that Schwann cells expressing &Dgr;SCIP induce regeneration of nervous tissue. Also provided by the present invention is a method for treating a subject in need of nervous tissue regeneration by introducing Schwann cells expressing &Dgr;SCIP into the subject.

Abstract: The present invention provides methods for inhibiting proliferation of astrocytes and astrocytic tumor cells. The present invention further provides methods for treating a condition associated with a defect in astrocyte proliferation in a subject, and methods for treating a condition associated with astrocytic tumor cell proliferation in a subject. Additionally, the present invention is directed to pharmaceutical compositions comprising CD81 protein or nucleic acid and a pharmaceutically-acceptable carrier. Finally, the present invention provides a method for determining whether a subject has an astrocytoma, and a method for assessing the efficacy of astrocytoma therapy in a subject.

Abstract: A rapid and accurate test kit is discussed for the detection of antibodies to HIV in saliva. The identification of antibodies to HIV in the saliva of seropositive individuals is shown using a test kit that requires no special machinery or skill and can be conducted by a single person in the privacy of their own home.