Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: The present disclosure relates to combinations of inhibitors of SOS1 and inhibitors of RAS useful in the treatment of diseases or disorders.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: A high-powered ISM band radio board includes a microprocessor, a radio transceiver coupled to the microprocessor, a timer crystal coupled to the radio transceiver, and a low-pass filter coupled to the radio transceiver. A transmission and reception line extends from the radio transceiver and terminates at an antenna and a transmission line stub extends from the transmission and reception line at a first end of the stub, has a length of one-quarter of a wavelength of a third harmonic of a signal output by the radio, and is open at a second end opposite the first end.

Abstract: An apparatus and method for retrofitting a wired luminaire to wireless control. The method includes coupling a sensor and the luminaire to the controller by wire and further includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, a zero to ten-volt luminaire control output, and a hardware switch with a single microcontroller.

Abstract: An apparatus and method for retrofitting a wired luminaire to wireless control. The method includes coupling a sensor and the luminaire to the controller by wire and further includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, a zero to ten-volt luminaire control output, and a hardware switch with a single microcontroller.

Abstract: An apparatus and method for controlling a universal wireless luminaire. The method includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, two zero to ten volt luminaire control outputs, a tunable white temperature luminaire control output, a universal asynchronous receiver-transmitter, and a hardware switch with a single microcontroller.

Abstract: An apparatus and method for controlling a universal wireless luminaire. The method includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, two zero to ten volt luminaire control outputs, a tunable white temperature luminaire control output, a universal asynchronous receiver-transmitter, and a hardware switch with a single microcontroller.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Abstract: Described are variants of alpha-amylase enzymes for use in industrial processes, such as liquefaction of starch. The alpha-amylase variants have increased specific activity allowing the more rapidly reduction of peak viscosity during liquefaction processes. The alpha-amylase is modified by introducing into the amino sequence of a parent Family 13 alpha-amylase polypeptide a mutation at an amino acid residue in the starch-binding groove; wherein the starch-binding groove is formed by amino acid residues in the alpha-helix preceding the first beta-strand in the A domain, the loop between the sixth alpha-helix and the seventh beta-strand in the A domain, the loop between the seventh alpha-helix and the eighth beta-strand in the A domain, and the loop connecting the A domain and the C domain; and wherein the mutation alters the binding of starch to the variant alpha amylase polypeptide compared to the parental alpha amylase polypeptide.

Abstract: A cryosurgical probe is adapted for the freezing of a nerve and is fitted with an electrode at its tip for electrical stimulation of the nerve, to enable the surgeon to know when the probe tip has been correctly placed in proximity to a particular nerve which it is desired to freeze.