Patents by Inventor David E. Wildes
David E. Wildes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11920170Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: GrantFiled: December 9, 2016Date of Patent: March 5, 2024Assignee: DANISCO US INC.Inventors: William Cuevas, Vivek Sharma, David E. Wildes, Sang-Kyu Lee, Dina Finan
-
Publication number: 20240058341Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.Type: ApplicationFiled: February 8, 2023Publication date: February 22, 2024Applicant: Revolution Medicines, Inc.Inventors: Robert J. Nichols, Mark A. Goldsmith, Christopher Schulze, Jaqueline Smith, David E. Wildes, Stephen Kelsey, Mallika Singh
-
Publication number: 20230226186Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.Type: ApplicationFiled: March 23, 2023Publication date: July 20, 2023Inventors: Naing AAY, G. Leslie BURNETT, James CREGG, Adrian L. GILL, John E. KNOX, Elena S. KOLTUN, Yang LIU, Andreas BUCKL, Bianca Jennifer LEE, David E. WILDES, Meghan A. RICE, Mallika SINGH
-
Patent number: 11690915Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.Type: GrantFiled: September 15, 2021Date of Patent: July 4, 2023Assignee: Revolution Medicines, Inc.Inventors: Naing Aay, G. Leslie Burnett, James Cregg, Adrian L. Gill, John E. Knox, Elena S. Koltun, Yang Liu, Andreas Buckl, Bianca Jennifer Lee, David E. Wildes, Meghan A. Rice, Mallika Singh
-
Patent number: 11596633Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.Type: GrantFiled: March 5, 2020Date of Patent: March 7, 2023Assignee: Revolution Medicines, Inc.Inventors: Robert J. Nichols, Mark A. Goldsmith, Christopher Schulze, Jacqueline Smith, David E. Wildes, Stephen Kelsey, Mallika Singh
-
Publication number: 20220105185Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.Type: ApplicationFiled: September 15, 2021Publication date: April 7, 2022Inventors: Naing AAY, G. Leslie BURNETT, James CREGG, Adrian L. GILL, John E. KNOX, Elena S. KOLTUN, Yang LIU, Andreas BUCKL, Bianca Jennifer LEE, David E. WILDES, Meghan A. RICE, Mallika SINGH
-
Publication number: 20210154190Abstract: The present disclosure provides methods of treating diseases or disorders related to mutations in the SHP2 gene using allosteric inhibitors of SHP2 and methods and diagnostic tests for identifying subjects susceptible or resistant to allosteric inhibitors of SHP2. In particular, the present disclosure provides allosteric inhibitor-sensitive mutations and allosteric inhibitor-resistant mutations of SHP2 for diagnostic and therapeutic use.Type: ApplicationFiled: October 6, 2020Publication date: May 27, 2021Inventors: David E. WILDES, Carlos STAHLHUT-ESPINOSA, Robert J. NICHOLS
-
Publication number: 20200368238Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.Type: ApplicationFiled: March 5, 2020Publication date: November 26, 2020Inventors: Robert J. NICHOLS, Mark A. GOLDSMITH, Christopher SCHULZE, Jacqueline SMITH, David E. WILDES, Stephen KELSEY, Mallika SINGH
-
Publication number: 20200112920Abstract: A high-powered ISM band radio board includes a microprocessor, a radio transceiver coupled to the microprocessor, a timer crystal coupled to the radio transceiver, and a low-pass filter coupled to the radio transceiver. A transmission and reception line extends from the radio transceiver and terminates at an antenna and a transmission line stub extends from the transmission and reception line at a first end of the stub, has a length of one-quarter of a wavelength of a third harmonic of a signal output by the radio, and is open at a second end opposite the first end.Type: ApplicationFiled: October 5, 2018Publication date: April 9, 2020Applicant: California Eastern Laboratories, Inc.Inventor: David E. Wilde
-
Patent number: 10609780Abstract: An apparatus and method for retrofitting a wired luminaire to wireless control. The method includes coupling a sensor and the luminaire to the controller by wire and further includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, a zero to ten-volt luminaire control output, and a hardware switch with a single microcontroller.Type: GrantFiled: July 30, 2019Date of Patent: March 31, 2020Assignee: California Eastern Laboratories, Inc.Inventors: Aren M. Thompson, Erik J. Davidson, David Parrett, David E. Wilde
-
Publication number: 20200037411Abstract: An apparatus and method for retrofitting a wired luminaire to wireless control. The method includes coupling a sensor and the luminaire to the controller by wire and further includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, a zero to ten-volt luminaire control output, and a hardware switch with a single microcontroller.Type: ApplicationFiled: July 30, 2019Publication date: January 30, 2020Inventors: Aren M. Thompson, Erik J. Davidson, David Parrett, David E. Wilde
-
Patent number: 10440793Abstract: An apparatus and method for controlling a universal wireless luminaire. The method includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, two zero to ten volt luminaire control outputs, a tunable white temperature luminaire control output, a universal asynchronous receiver-transmitter, and a hardware switch with a single microcontroller.Type: GrantFiled: January 25, 2019Date of Patent: October 8, 2019Assignee: California Eastern Laboratories, Inc.Inventor: David E. Wilde
-
Patent number: 10314132Abstract: An apparatus and method for controlling a universal wireless luminaire. The method includes controlling a separate memory device, a radio, a relay for switching power to a luminaire, two zero to ten volt luminaire control outputs, a tunable white temperature luminaire control output, a universal asynchronous receiver-transmitter, and a hardware switch with a single microcontroller.Type: GrantFiled: July 26, 2018Date of Patent: June 4, 2019Assignee: California Eastern Laboratories, Inc.Inventor: David E. Wilde
-
Publication number: 20190144842Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: ApplicationFiled: December 9, 2016Publication date: May 16, 2019Inventors: William Cuevas, Vivek Sharma, David E. Wildes, Sang-Kyu Lee, Dina Finan
-
Publication number: 20180163191Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: ApplicationFiled: February 2, 2017Publication date: June 14, 2018Applicant: Danisco US Inc.Inventors: William Cuevas, Vivek Sharma, David E. Wildes, Sang-kyu Lee, Dina Finan
-
Publication number: 20160017304Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: ApplicationFiled: March 11, 2014Publication date: January 21, 2016Applicant: DANISCO US INC.Inventors: Luis G. Cascao-Pereira, Dina Finan, David E. Wildes, Marc Kolkman, Richard R. Bott, Pieter Augustinus, Roel Hermant, Monica Ocha, Dewy Van Tol
-
Publication number: 20160017305Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: ApplicationFiled: March 11, 2014Publication date: January 21, 2016Applicant: DANISCO US INC.Inventors: Luis G. Cascao-Pereira, Dina Finan, David E. Wildes, Marc Kolkman, Richard R. Bott, Pieter Augustinus, Roel Hermant, Monica Ocha Ruiz, Dewy Van Tol
-
Publication number: 20160017303Abstract: Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.Type: ApplicationFiled: March 11, 2014Publication date: January 21, 2016Applicant: DANISCO US INC.Inventors: Luis G. Cascao-Pereira, Dina Finan, David E. Wildes, Marc Kolkman, Richard R. Bott, Pieter Augustinus, Roel Hermant, Monica Ocha Ruiz, Dewy Van Tol
-
Publication number: 20150141316Abstract: Described are variants of alpha-amylase enzymes for use in industrial processes, such as liquefaction of starch. The alpha-amylase variants have increased specific activity allowing the more rapidly reduction of peak viscosity during liquefaction processes. The alpha-amylase is modified by introducing into the amino sequence of a parent Family 13 alpha-amylase polypeptide a mutation at an amino acid residue in the starch-binding groove; wherein the starch-binding groove is formed by amino acid residues in the alpha-helix preceding the first beta-strand in the A domain, the loop between the sixth alpha-helix and the seventh beta-strand in the A domain, the loop between the seventh alpha-helix and the eighth beta-strand in the A domain, and the loop connecting the A domain and the C domain; and wherein the mutation alters the binding of starch to the variant alpha amylase polypeptide compared to the parental alpha amylase polypeptide.Type: ApplicationFiled: May 24, 2013Publication date: May 21, 2015Applicant: DANISCO US INC.Inventors: Richard R. Bott, Luis G. Cascao-Pereira, David A. Estell, Marc Kolkman, David E. Wildes