Abstract: Porous filters having uniform pore size and close packing density are described, along with methods and apparatus for making the porous filters based on nanopatterning. One method includes applying a polymeric liquid to a mold consisting of an array of posts having a desired pore size and distribution. Solidification of polymeric membrane followed by separation from the mold produces a polymer membrane with a predetermined spaced array of pores. A pre-filter film can also be bonded with the membrane during formation to provide increased mechanical support and filtration of larger particles on the input side of the filter. Other process variants are described, including methods for incorporating additional functionalities to the filter.

Abstract: A rotary position encoder is described that includes a hub configured to mount on an end of a rotatable shaft of a machine tool and rotate concurrently with the rotatable shaft. The hub includes a cup formed in a first end to receive the rotatable shaft, the cup having equally spaced axial grooves formed on an inner surface. A collar clamps the hub to the rotatable shaft by collapsing the cup around the rotatable shaft. The rotary position encoder further includes a sensor configured to detect a rotational position of the hub and a housing, wherein the sensor is mounted to the housing in a position opposite a second end of the hub. The hub is rotatably coupled to the housing via a bearing and a bracket is attached to the housing for mounting the rotary position encoder to the machine tool and preloading the bearing.

Abstract: Systems, devices and methods for monitoring hemodynamics are described. The systems and methods generally involve directing light toward an area of the body and detecting the resulting scattered light. The scattered light is detected and an electrical signal representative of the scattered light intensity is generated from the detected light. The electrical signal is analyzed by measuring temporal fluctuations of such signals to monitor pathological states over time including hemorrhagic shock, hypoxia, and tissue graft vascularization. Such monitoring can have significant benefits to patients.

Abstract: A method for commanding an attitude change of a boosting missile to tend to maintain good communication link quality includes the step of precalculating attenuation of a link between the boosting missile and a ground station in the presence and absence of multiple missile plumes. If the actual link attenuation is less than the precalculated attenuation in the absence of multiple missile plumes, no attitude change is commanded. If the actual link attenuation exceeds the precalculated value, the actual link attenuation is compared with the calculated attenuation in the presence of multiple missile plumes. If the calculated multiple plume RF attenuation is less than the actual link attenuation, the attenuation is deemed to be caused by some factor other than multiple plume attenuation, and produces a flag for commanding a change in attitude.

Abstract: Systems, devices and methods for monitoring hemodynamics are described. The systems and methods generally involve directing light toward an area of the body and detecting the resulting scattered light. The scattered light is detected and an electrical signal representative of the scattered light intensity is generated from the detected light. The electrical signal is analyzed by measuring temporal fluctuations of such signals to monitor pathological states over time including hemorrhagic shock, hypoxia, and tissue graft vascularization. Such monitoring can have significant benefits to patients.

Abstract: A rotary position encoder is described that includes a hub configured to mount on an end of a rotatable shaft of a machine tool and rotate concurrently with the rotatable shaft. The hub includes a cup formed in a first end to receive the rotatable shaft, the cup having equally spaced axial grooves formed on an inner surface. A collar clamps the hub to the rotatable shaft by collapsing the cup around the rotatable shaft. The rotary position encoder further includes a sensor configured to detect a rotational position of the hub and a housing, wherein the sensor is mounted to the housing in a position opposite a second end of the hub. The hub is rotatably coupled to the housing via a bearing and a bracket is attached to the housing for mounting the rotary position encoder to the machine tool and preloading the bearing.

Abstract: A system for controlling a machine tool is provided. The system includes a user input device deflectable from a neutral position and a controller configured to receive information corresponding to an amount of deflection of the user input device from the neutral position and to output a control signal to control a movement of the machine tool in an axis of movement at a rate corresponding to the amount of deflection of the user input device from the neutral position. A machine is provided, including a work tool movable along an axis of movement and a control system including a user input device deflectable from a neutral position and a controller configured to receive information corresponding to an amount of deflection of the user input device from the neutral position and to output a control signal to control a movement of the work tool in an axis of movement at a rate corresponding to the amount of deflection of the user input device from the neutral position.

Abstract: A system for controlling a machine tool is provided. The system includes a user input device deflectable from a neutral position and a controller configured to receive information corresponding to an amount of deflection of the user input device from the neutral position and to output a control signal to control a movement of the machine tool in an axis of movement at a rate corresponding to the amount of deflection of the user input device from the neutral position. A machine is provided, including a work tool movable along an axis of movement and a control system including a user input device deflectable from a neutral position and a controller configured to receive information corresponding to an amount of deflection of the user input device from the neutral position and to output a control signal to control a movement of the work tool in an axis of movement at a rate corresponding to the amount of deflection of the user input device from the neutral position.

Abstract: A methodology determines the offset distance between a threat missile plume and its hardbody during boost phase to aid in guiding a kinetic weapon (KW) or interceptor missile to the threat missile hardbody using the KW infrared sensor of the interceptor missile in conjunction with a radar sensor.

Abstract: A target missile identifier compares radar cross-section (RCS) information about the missile with a set including at least one template of RCS to make determination(s) of at least one of (a) the missile type (solid/liquid propellant), (b) missile main engine cutoff, andor (c) staging state of a multistage missile.

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument that includes an excitation source, at least one of a light focusing element positioned to receive light emitted by the excitation source, a detector for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupled to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

Abstract: The invention is based on the discovery of reduced valency carbohydrate binding ligands (CBLs) that can be used to to detect or quantitate (i.e., evaluate) carbohydrates in a sample. CBLs can be used with fluorescence resonance energy transfer (FRET) to evaluate free carbohydrates or those within a carbohydrate containing compound.

Abstract: A system for detecting analyte that includes a sensor adapted to detect the analyte, the sensor including a polymer matrix, fluorophores and a membrane, an excitation source to excite a fluorophore of the sensor, a first detector adapted to detect light of a first wavelength emitted by the sensor, a second detector adapted to detect light of a second wavelength emitted by the sensor, and a processor for processing signals corresponding to light detected by the detectors.

Abstract: An article is disclosed that includes a core and a selectively permeable coating enclosing the core. The coating includes a monodisperse polymer.

Abstract: The invention features a method of assaying for the interaction of a probe and an unknown target, said method including a) exciting a sample with radiation, the sample including at least one unknown target, at least one probe, and at least one fluorescent tag, b) measuring the fluorescence from a subvolume of the sample, and c) analyzing the fluctuations of the fluorescence.

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument that includes an excitation source, at least one of a light focusing element positioned to receive light emitted by the excitation source, a detector for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupled to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

Abstract: A method of determining a suitable microreactor for a predetermined host including identifying a suitable microreactor diameter, optionally identifying a minimum second matrix thickness, and optionally identifying a microreactor having a centrally located microcapsule.

Abstract: A method of identifying an analyte-ligand binding pair that exhibits non-radiative fluorescence resonance energy transfer (FRET) using a combinatorial library. The method includes a) obtaining an analyte binding ligand from a combinatorial library that includes ligands, and b) attaching a label at least one of the analyte binding ligand and an analyte-analogue with at least one of a first component and a second component of a non-radiative fluorescence resonance energy transfer donor-acceptor pair (FRET pair) such that FRET occurs when the analyte-analogue is bound to the analyte binding ligand, and a change in FRET occurs when the analyte-analogue is not bound to the analyte binding ligand.

Abstract: A method of evaluating a carbohydrate in a sample. The method includes providing a low valency carbohydrate binding ligand, providing a glycoconjugate which includes a label, and a carbohydrate moiety, contacting the low valency carbohydrate binding ligand and the glycoconjugate with the sample, determining the extent of binding of the low valency carbohydrate binding ligand with the glycoconjugate, the binding of the low valency carbohydrate binding ligand with the glycoconjugate being correlated with the amount of carbohydrate in the sample.

Abstract: An in vivo method and apparatus for detecting an analyte in an individual. A sensor that includes a fluorescence reagent is placed in communication with the body fluids of the individual suspected of containing the analyte in such a way that once in place said sensor does not exit the skin of the individual. The sensor is configured to retain the fluorescence reagent while allowing analyte to diffuse into and out of said sensor. The sensor is illuminated transdermally, and the fluorescence from the fluorescence reagent associated with the presence of the analyte is measured.