Patents by Inventor David E. Zembower

David E. Zembower has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
    Publication number: 20190382348
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Application
    Filed: January 11, 2019
    Publication date: December 19, 2019
    Inventors: David E. Zembower, David A. Eiznhamer
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION
    Publication number: 20190076417
    Abstract: The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
    Type: Application
    Filed: April 2, 2018
    Publication date: March 14, 2019
    Inventors: Rishi Arora, David E. Zembower
  • Compositions and methods for treating or preventing atrial fibrillation
    Patent number: 9931333
    Abstract: The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 3, 2018
    Assignee: Northwestern University
    Inventors: Rishi Arora, David E. Zembower
  • Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity
    Patent number: 9663471
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: May 30, 2017
    Assignee: Angion Biomedica Corporation
    Inventors: David E. Zembower, David A. Eiznhamer
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION
    Publication number: 20170100387
    Abstract: The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
    Type: Application
    Filed: October 25, 2016
    Publication date: April 13, 2017
    Inventors: Rishi Arora, David E. Zembower
  • PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
    Publication number: 20140256780
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Application
    Filed: October 7, 2013
    Publication date: September 11, 2014
    Applicant: Angion Biomedica Corporation
    Inventors: David E. Zembower, David A. Eiznhamer
  • Small molecule modulators of hepatocyte growth factor (scatter factor) activity
    Patent number: 8580834
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: November 12, 2013
    Assignee: Angion Biomedica Corp.
    Inventors: David E. Zembower, David A. Eiznhamer
  • THERAPEUTIC VESICLES
    Publication number: 20120093885
    Abstract: The present technology provides compositions of vesicles, uses of vesicles, and methods relating to vesicles. For example, provided herein are vesicles derived from stem cells for use in regenerative therapies.
    Type: Application
    Filed: October 18, 2011
    Publication date: April 19, 2012
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Susmita Sahoo, Douglas W. Losordo, David E. Zembower
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION
    Publication number: 20110281853
    Abstract: The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
    Type: Application
    Filed: May 12, 2011
    Publication date: November 17, 2011
    Inventors: Rishi Arora, David E. Zembower
  • METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS
    Publication number: 20110098309
    Abstract: Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ?1-42 oligomers from amyloid ?1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ?1-42 oligomers using acylhydrazide compounds.
    Type: Application
    Filed: July 11, 2008
    Publication date: April 28, 2011
    Applicant: ACUMEN PHARMACEUTICALS, INC.
    Inventors: Gary Charles Look, Lauri Schultz, Alexandre Mikhaylovich Polozov, Nikhil Bhagat, Jian Wang, David E. Zembower, William F. Goure, Todd Pray, Grant A. Krafft
  • SMALL MOLECULE MODULATORS OF CYTOKINE ACTIVITY
    Publication number: 20100137285
    Abstract: The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: David E. Zembower, Jasbir Singh, Rama K. Mishra
  • Small molecule modulators of cytokine activity
    Patent number: 7648978
    Abstract: The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: January 19, 2010
    Assignee: Angion Biomedica Corp.
    Inventors: David E. Zembower, Jasbir Singh, Rama K. Mishra
  • Process for preparing 7-(acryloyl)indoles
    Patent number: 7579483
    Abstract: The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: August 25, 2009
    Assignee: deCODE Genetics, ehf.
    Inventors: Jasbir Singh, Siead I. Zegar, David E. Zembower, Christopher J. Tokar, Livia A. Enache, Wayne E. Zeller
  • PROCESS FOR PREPARING 7-(ACRYLOYL)INDOLES
    Publication number: 20070270594
    Abstract: The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
    Type: Application
    Filed: May 15, 2007
    Publication date: November 22, 2007
    Applicant: DECODE GENETICS, EHF.
    Inventors: Jasbir Singh, Siead I. Zegar, David E. Zembower, Christopher J. Tokar, Livia A. Enache, Wayne E. Zeller
  • Small molecule modulators of hepatocyte growth factor (scatter factor) activity
    Patent number: 7265112
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: September 4, 2007
    Assignee: Angion Biomedica Corp.
    Inventors: David E. Zembower, David A. Eiznhamer
  • Small molecule modulators of hepatocyte growth factor (scatter factor) activity
    Patent number: 7250437
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: July 31, 2007
    Assignee: Angion Biomedica Corp.
    Inventors: David E. Zembower, David A. Eiznhamer
  • Small molecule modulators of hepatocyte growth factor (scatter factor) activity
    Patent number: 7192976
    Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: March 20, 2007
    Assignee: Angion Biomedica Corporation
    Inventors: David E. Zembower, David A. Eiznhamer
  • Small molecule modulators of hepatocyte growth factor (scatter factor) activity
    Publication number: 20040180882
    Abstract: The present invention provides compounds having formula (I): 1
    Type: Application
    Filed: December 18, 2003
    Publication date: September 16, 2004
    Inventors: David E. Zembower, David A. Eiznhamer
  • Indolocarbazole anticancer agents and methods of using them
    Patent number: 6605596
    Abstract: The present invention relates to anti-tumor compounds, compositions and methods.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: August 12, 2003
    Assignee: Advanced Life Sciences, Inc.
    Inventors: David E. Zembower, Yongping Xie, Yasheen Zhou
  • Indolocarbazole anticancer agents and methods of using them
    Publication number: 20030087842
    Abstract: The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity.
    Type: Application
    Filed: October 29, 2001
    Publication date: May 8, 2003
    Applicant: Advanced Life Sciences, Inc.
    Inventors: David E. Zembower, Yongping Xie, Yasheen Zhou