Abstract: The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use. The active agent dosage form is a multilayer core, often bilayer, formed of polymer matrices that swell upon contact with the fluids of the stomach. At least one layer of the multilayered dosage form includes an active agent. A portion of the polymer matrices are surrounded by a band of insoluble material that prevents the covered portion of the polymer matrices from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

Abstract: A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

Abstract: Dosage forms and devices for enhancing controlled delivery of lowly soluble active agents including topiramate by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a drug core composition for delivering high doses of lowly soluble topiramate in solid oral drug delivery systems that are convenient to swallow, for once-a-day administration. The drug core composition contains topiramate, a surfactant and a carrier in ratios for optimal solubility and delivery.

Abstract: Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.

Abstract: A diffusional drug delivery device is described which can provide shelf life stability of the system components, elimination of the initial burst of drug and hence irritation, delayed onset of therapeutic effect and delivery of a therapeutic agent at an optimum rate. A metal layer and an activating means are inert when dry. Moisture activates the system whereby the activating means provides release of an eroding agent which erodes the metal layer through which the therapeutic agent diffuses and is subsequently delivered.

Abstract: An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.

Abstract: An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.

Abstract: An osmotic dispenser is disclosed for releasing drug formulation in the gastrointestinal tract. The dispenser comprises a semipermeable-enteric wall surrounding a compartment housing drug formulation. A passageway in the wall communicates with the compartment for dispensing drug formulation.

Abstract: An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.

Abstract: An osmotic device is disclosed for delivering a beneficial agent to a first environment having a pH of 1.0 to 3.5 inclusive and to a second environment having a pH of greater than 3.5 to 8.0. The device maintains its integrity in the first environment and loses its integrity in the second environment.

Abstract: An osmotic device is disclosed that provides a means for improving the delivery properties of a beneficial agent in situ.

Abstract: An osmotic device is disclosed that provides a means for improving the delivery properties of a beneficial agent in situ.

Abstract: An osmotic device is disclosed that provides a means for improving the delivery properties of a beneficial agent in situ.