Patents by Inventor David Edwin Gruber

David Edwin Gruber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of recombinantly produced polypeptides
    Patent number: 10259842
    Abstract: Described herein is a method for separating a recombinantly produced polypeptide from host cell protein. The method includes a step of loading a clarified cell culture supernatant that includes the recombinantly produced polypeptide and the HCP onto a Protein A chromatography column and washing the Protein A chromatography column with a wash buffer comprising a fatty acid having a chain length of at least about 6 carbon atoms, or a fatty acid salt thereof to remove HCP and then recovering the recombinantly produced polypeptide.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: April 16, 2019
    Assignees: MedImmune, LLC, Medimmune Limited
    Inventors: David Edwin Gruber, Richard Edward Turner, Jared Samuel Bee, Christopher Douglas Afdahl, Liu Tie
  • Purification Of Recombinantly Produced Polypeptides
    Publication number: 20160108084
    Abstract: Described herein is a method for separating a recombinantly produced polypeptide from host cell protein. The method includes a step of loading a clarified cell culture supernatant that includes the recombinantly produced polypeptide and the HCP onto a Protein A chromatography column and washing the Protein A chromatography column with a wash buffer comprising a fatty acid having a chain length of at least about 6 carbon atoms, or a fatty acid salt thereof to remove HCP and then recovering the recombinantly produced polypeptide.
    Type: Application
    Filed: May 13, 2014
    Publication date: April 21, 2016
    Applicant: Medlmmune Limited
    Inventors: David Edwin Gruber, Richard Edward Turner, Jares Samuel Bee, Christopher Samuel Afdahi, Liu Tie