Abstract: A system and method for method for facilitating interactions with a digital avatar. The method includes the steps of generating artificial intelligence-based digital avatars for people wherein the digital avatars learn over time to mimic the personalities of their masters. Digital avatars can behave and express themselves like real people. The method includes establishing interactions between two digital avatars of two different people, or between a real person and a digital avatar of another person. The method allows a person to date an avatar of another person like dating a real person.

Abstract: Compositions and methods are provided for modifying the expression or activity of CXorf67 in order to reduce the activity of PRC2. Increased expression of CXorf67 was identified in certain cancers, including PFA ependymomas. Thus, provided herein are methods for reducing PRC2 activity in order to treat cancer. The methods and compositions can be used to treat symptoms cancer or to screen for compounds useful in decreasing PRC2 activity and treating cancer. Further provided are methods of identifying subjects at an increased risk of developing cancer by measuring the expression or activity of CXorf67 or the mutation of specific sites within CXorf67.

Abstract: A slider is provided with a conformal coating (e.g., an oxide) on the air-bearing surface (ABS) to provide a consistent surface energy to the ABS. The conformal coating may be formed by an atomic layer deposition (ALD) process. A consistent surface energy inhibits accumulation of contaminants on the slider ABS, such as at topographical transition areas.

Abstract: A slider is provided with a conformal coating (e.g., an oxide) on the air-bearing surface (ABS) to provide a consistent surface energy to the ABS. The conformal coating may be formed by an atomic layer deposition (ALD) process. A consistent surface energy inhibits accumulation of contaminants on the slider ABS, such as at topographical transition areas.

Abstract: A slider is provided with a conformal coating (e.g., an oxide) on the air-bearing surface (ABS) to provide a consistent surface energy to the ABS. The conformal coating may be formed by an atomic layer deposition (ALD) process. A consistent surface energy inhibits accumulation of contaminants on the slider ABS, such as at topographical transition areas.

Abstract: A cleaning head and methods for removing contaminants from a data storage media, the cleaning head having a cleaning surface comprising a self-assembled monolayer, with the cleaning surface leading a read/write transducer. The self-assembled monolayer is selected to have a terminal functional group that has a high affinity to the contaminant(s) desired to be attracted and/or removed.

Abstract: A cleaning head and methods for removing contaminants from a data storage media, the cleaning head having a cleaning surface comprising a self-assembled monolayer, with the cleaning surface leading a read/write transducer. The self-assembled monolayer is selected to have a terminal functional group that has a high affinity to the contaminant(s) desired to be attracted and/or removed.

Abstract: Computer program products, methods, systems, apparatus, and computing entities are provided for determining whether available and executing time compressed/sensitive delivery. In one exemplary embodiment, a method may comprise receiving an electronic notification comprising pick-up locations, delivery locations and a time window, determining whether the items can be picked up at the pick-up locations and delivered to one of the delivery locations within the time window based on available delivery vehicles, available delivery drivers, planned routes, physical vehicle capacity, planned sort capabilities, available meet points, and available pick-up times, and in an instance in which it is determined that the items can be picked up at one of the pick-up locations and delivered to one of the delivery locations within the time window, providing an affirmative response.

Abstract: A cleaning head and methods for removing contaminants from a data storage media, the cleaning head having a cleaning surface comprising a self-assembled monolayer, with the cleaning surface leading a read/write transducer. The self-assembled monolayer is selected to have a terminal functional group that has a high affinity to the contaminant(s) desired to be attracted and/or removed.

Abstract: Immunohistochemical methods and compositions for the typing of molecular subgroups of medulloblastomas are provided. The methods comprise determining a protein expression profile for a sample obtained from a medulloblastoma by detecting expression of GAB1, filamin A, or at least two biomarker proteins selected from the group consisting of ?-catenin, YAP1, GAB1, and filamin A, and typing the medulloblastoma as a WNT pathway tumor, a SHH pathway tumor, or a non-WNT/non-SHH tumor based on this protein expression profile. Kits for typing a medulloblastoma according to these three molecular subgroups are provided. The kits comprise at least two antibodies, wherein each of said antibodies specifically binds to a distinct biomarker protein selected from the group consisting of ?-catenin, YAP1, GAB1, and filamin A, and can optionally comprise one or more of instructions for use, reagents for detecting antibody binding to one or more of said biomarker proteins, and one or more positive control samples.

Abstract: Immunohistochemical methods and compositions for the typing of molecular subgroups of medulloblastomas are provided. The methods comprise determining a protein expression profile for a sample obtained from a medulloblastoma by detecting expression of GAB 1, filamin A, or at least two biomarker proteins selected from the group consisting of ?-catenin, YAP1, GAB1, and filamin A, and typing the medulloblastoma as a WNT pathway tumor, a SHH pathway tumor, or a non-WNT/non-SHH tumor based on this protein expression profile. Kits for typing a medulloblastoma according to these three molecular subgroups are provided. The kits comprise at least two antibodies, wherein each of said antibodies specifically binds to a distinct biomarker protein selected from the group consisting of ?-catenin, YAP1, GAB1, and filamin A, and can optionally comprise one or more of instructions for use, reagents for detecting antibody binding to one or more of said biomarker proteins, and one or more positive control samples.

Abstract: A digital signal processing amplifier device has a programmable “drag and drop” digital signal processor (DSP), a power supply connected to the DSP and a modular or integral audio amplifier, all housed in a chassis. The amplifier is able to amplify and transmit a signal from the programmable DSP to an output device. To create an audio design, a user, via means of a computer which is in communication with the programmable DSP, may select and assign audio elements to create a virtual audio design. The computer and related software create a set of instructions from the virtual audio design and the instructions are transmitted from the computer to the programmable DSP. The DSP executes the instructions to modify an input signal to provide an output signal, and the output signal is then transmitted by the amplifier to an output device.

Abstract: A multifunction user interface provided as an add-on option to a more basic multifunction sensor which does not provide a display or keypad, to provide a local user interface to access and control parameters of a control network. The basic multifunction sensor provides a plurality of parameter sensors in one sensor housing, and can interface with and control operation of one or more processor control systems connected by a network bus in an occupied space networked environment. The basic sensor comprises at least an occupancy sensor, a temperature sensor, and a common network communications and control processor coupled to a common communication transceiver. This allows the basic multifunction sensor to interface with and control operation of one or more processor control systems in an occupied space networked environment.