Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinsons disease, Lewy body dementia, multiple system atrophy, Alzheimers disease, and other neurodegenerative diseases.

Abstract: In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and/or positioning of an intra-cardiac electrophysiological (EP) mapping basket or other EP mapping structure of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes and a statistical shape or other model of the EP mapping basket or other type of EP mapping structure, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex, and thereby permit accurate navigation within the heart and/or processing of data acquired using the EP mapping basket or other EP mapping structure.

Abstract: Electrographic flow mapping (EGF mapping) is a technique used for aiding catheter ablation when treating atrial fibrillation. Visualizing EGF fields during a cardiac catherization and ablation procedure is an important and necessary part of conducting the procedure. Several different visualization methods are described and disclosed herein that may be employed to visualize EGF fields and maps, including quiver plots, streamline plots, particle plots, particle trail plots, moving particle plots, and moving and fading particle plots.

Abstract: In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and or positioning of an intra-cardiac electrophysiological (EP) mapping basket of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex. The one or more computing devices can also be used to determine changes in the three-dimensional locations and orientations of the basket and the electrodes thereof as the basket is moved around, in, or near the patient's atrium, heart chamber, or other portion of the patient's heart.

Abstract: The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinson's disease, Lewy body dementia, multiple system atrophy, Alzheimer's disease, and other neurodegenerative diseases.

Abstract: The Continuous Sealing Machine for two plastic films performs continuous sealing of two films, a tubular with gussets and a plastic film, folds the gussets of the new compartment and as a result two compartment rolls are obtained, both compartments with gussets. This high performance machine provides the means for a modernization of the plastics industry. It is a machine on a main structure consisting of: Unwinders Outriggers Edge aligners Pulling roller systems Antistatic bars Antistatic bars Special device Motors with gearbox coupled to gearbox Automatic brakes Electromagnetic clutches continuous sealers Bellows former Camshaft sealers Front puller roll pitch motor Winding rods, foil positioning systems. It is part of the plastic industry machines together with extruders, printers, sealers, trimmers, raw material mixers and stencil assembly machines.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect the locations of sources of cardiac rhythm disorders in a patient's heart, and then to generate an estimate or probability of the patient being free from atrial fibrillation. The various embodiments employ at least one computing device to process a plurality of electrogram surfaces through time to generate at least one electrographical flow (EGF) map, representation, pattern, or data set, and then process the at least one EGF map, representation, pattern, or data set to determine at least two of source activity levels, flow angle variability (FAV) levels, and active fractionation (AFR) levels corresponding thereto. On the basis of a combination of the determined at least two of source activity levels, FAV levels, and AFR levels, an electrographical volatility index (EVI) score or metric representative of the estimate or probability of the patient being free from AF is generated.

Abstract: Electrographic flow mapping (EGF mapping) is a technique used for aiding catheter ablation when treating atrial fibrillation. Visualizing EGF fields during a cardiac catherization and ablation procedure is an important and necessary part of conducting the procedure. Several different visualization methods are described and disclosed herein that may be employed to visualize EGF fields and maps, including quiver plots, streamline plots, particle plots, particle trail plots, moving particle plots, and moving and fading particle plots.

Abstract: A server includes a processor and a memory connected to the processor. The memory stores instructions executed by the processor. The instructions receive medical event data from a mobile device, an identification for a patient and mobile device parameters. The identification for the patient is matched with medical records and response rules for the patient. The response rules are executed to selectively notify a civic responder and an incident management module. Communications with the patient and specified emergency contacts associated with the patient are coordinated.

Abstract: A method and apparatus for determining position and rotational orientation of an object within a predetermined area is disclosed. Position markers, encoded with their identity, are viewed with a camera, images are captured and processed, and the position and rotational orientation of the object are calculated. Three embodiments are disclosed; the first having a camera mounted on the movable object while position markers bearing linear bar codes are fixed in location, the second having a camera mounted on the movable object while position markers bearing two-dimensional bar codes are fixed in location, and the third having a position marker of either type affixed to the object while the camera is fixed in location.

Abstract: Multiple myeloma can be treated by administration of irinotecan combined with revimid. The present invention includes methods of treating multiple myeloma by administering the combination of irinotecan and revimid, as well as pharmaceutical kits.

Abstract: The present invention relates to a method for treating locally advanced or metastatic breast cancer in a patient who demonstrated failure of prior treatment with an anthracycline, a taxane and a fluoropyrimidine, which comprises administering a therapeutically effective amount of irinotecan.

Abstract: The golf ball of the present invention has a white core which has a bright, white outer surface and a relatively thin, translucent cover composed of SURLYN.RTM. having a thickness of about 0.06 inches or less. The translucent SURLYN.RTM. cover contains between 6% and 12% by weight photostorage material, of the type having components such as aluminum oxide, strontium oxide, calcium oxide, europium oxide and boron oxide. A brightly colored fluorescent dye at a concentration between 0.01% and 0.04% by weight can also be added to a SURLYN.RTM. cover material to produce a golf ball of the present invention that is brightly colored. When the golf ball of the present invention has no fluorescent dye in its cover, it is substantially white in appearance, is visible in daylight and after being charged by exposure to light, emits a long lasting bright glow of light for high visibility in the dark.

Abstract: The safety and arming device timer is a small, inexpensive, highly accurate lectronic time delay compatible with the existing electronics for a safety and arming device for a guided projectile to provide for safe separation of the projectile from the gun.