Abstract: A system includes an autonomous robotic system and a docking system deployed by a seaborne vessel. The docking system houses the autonomous robotic system and couples to a subsea structure of a subsea system. The subsea structure is disposed on a sea floor. The autonomous robotic system deploys from the docking system into a wellbore of a subsea well of the subsea system. The autonomous robotic system also moves within the wellbore.

Abstract: Systems and methods presented herein provide for cutting in a borehole or casing. A cutting device can include a first arm having a cutting blade, wherein the cutting blade has side cutting teeth and an axis of rotation that is substantially at a right angle with respect to an axis of the tool body. The cutting device can also include a second arm with a bumper. The first and second arms articulate away from the elongate body in different directions to reduce vibrations while cutting. A control device can automate the cut based on hydraulic pressure measurements. Additionally, the cutting device can also be extended or rotated on a rotary index. The cutting device can rotate around a J slot, in an example.

Abstract: Systems and methods for downhole tubular cutting applications can include a cutting tool that with a cutting head, an anchor module, and a hydraulic module that actuates both. Arms of the anchor module open to an inner surface of a tube prior to blades of the cutting head opening to the inner surface. The blades can be operated by a piston. The piston can include a detent that travels across an actuation profile. This can allow a processor to track the cutting position. The processor can adjust the rotational speed of the blades based on feedback from the system.

Abstract: Systems and methods are disclosed herein for performing a milling operation within a wellbore in an oil-and-gas setting. An example system can include a milling tool, which can include a cutting head, a linear actuator configured to advance the cutting head, and a linear displacement measurement sensor associated with the linear actuator. The sensor can be configured to measure linear displacement of the linear actuator. The system can also include a cable to lower the milling tool, a control unit that receives data from the sensor, and a display device that displays a visualization of the data from the sensor. The control unit can analyze the data to determine a location of a milling target, a status of the milling operation, and undesirable milling conditions down hole. The control unit can perform a remedial action, such as by turning on a pump to remove debris from the wellbore.

Abstract: Systems and methods presented herein provide for well de-commissioning and other operations in through-tubing applications. A control device analyzes the well to plan a reconfiguration, wherein the reconfiguration eliminates flow through a control line in the well. A downhole tool fills the control line, segments the control line into smaller sections, confirms positioning of the sections following the segmenting. The control device measures a state of the well in real time during the filling and segmenting, and wherein the filing and segmenting are modified based on the measured state. Additionally, a washing operation can be performed to remove residuals prior to performing a cementing operation to fill the annular space.

Abstract: Systems and methods for downhole tubular cutting applications can include a cutting tool that with a cutting head, an anchor module, and a hydraulic module that actuates both. Arms of the anchor module open to an inner surface of a tube prior to blades of the cutting head opening to the inner surface. The blades can be operated by a piston. The piston can include a detent that travels across an actuation profile. This can allow a processor to track the cutting position. The processor can adjust the rotational speed of the blades based on feedback from the system.

Abstract: A system includes an autonomous robotic system and a docking system deployed by a seaborne vessel. The docking system houses the autonomous robotic system and couples to a subsea structure of a subsea system. The subsea structure is disposed on a sea floor. The autonomous robotic system deploys from the docking system into a wellbore of a subsea well of the subsea system. The autonomous robotic system also moves within the wellbore.

Abstract: Systems and methods for downhole tubular cutting applications can include a cutting tool that with a cutting head, an anchor module, and a hydraulic module that actuates both. Arms of the anchor module open to an inner surface of a tube prior to blades of the cutting head opening to the inner surface. The blades can be operated by a piston. The piston can include a detent that travels across an actuation profile. This can allow a processor to track the cutting position. The processor can adjust the rotational speed of the blades based on feedback from the system.

Abstract: Systems and methods presented herein provide for cutting in a borehole or casing. A cutting device can include a first arm having a cutting blade, wherein the cutting blade has side cutting teeth and an axis of rotation that is substantially at a right angle with respect to an axis of the tool body. The cutting device can also include a second arm with a bumper. The first and second arms articulate away from the elongate body in different directions to reduce vibrations while cutting. A control device can automate the cut based on hydraulic pressure measurements. Additionally, the cutting device can also be extended or rotated on a rotary index. The cutting device can rotate around a J slot, in an example.

Abstract: Systems and methods presented herein provide for cutting in a borehole or casing. A cutting device can include a first arm having a cutting blade, wherein the cutting blade has side cutting teeth and an axis of rotation that is substantially at a right angle with respect to an axis of the tool body. The cutting device can also include a second arm with a bumper. The first and second arms articulate away from the elongate body in different directions to reduce vibrations while cutting. A control device can automate the cut based on hydraulic pressure measurements. Additionally, the cutting device can also be extended or rotated on a rotary index. The cutting device can rotate around a J slot, in an example.

Abstract: Devices, systems and methods for cutting openings in a wellbore tubular by a slot cutting assembly having an anchoring system and a slot cutting tool. The anchoring assembly anchors the slot cutting assembly within the wellbore. The slot cutting tool has an extendable cutting blade that is pushed into the wellbore tubular to cut an opening through the tubular. The slot cutting tool may have an extendable stabilizing arm to stabilize and assist with cutting by the blade. The slot cutting assembly may have azimuth and depth sensors to assist with positioning the tool at a desired position downhole. A surface system may be used to control the position of the slot cutting assembly downhole.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: Systems and methods presented herein provide for cutting in a borehole or casing. A cutting device can include a first arm having a cutting blade, wherein the cutting blade has side cutting teeth and an axis of rotation that is substantially at a right angle with respect to an axis of the tool body. The cutting device can also include a second arm with a bumper. The first and second arms articulate away from the elongate body in different directions to reduce vibrations while cutting. A control device can automate the cut based on hydraulic pressure measurements. Additionally, the cutting device can also be extended or rotated on a rotary index. The cutting device can rotate around a J slot, in an example.

Abstract: Devices, systems and methods for cutting openings in a wellbore tubular by a slot cutting assembly having an anchoring system and a slot cutting tool. The anchoring assembly anchors the slot cutting assembly within the wellbore. The slot cutting tool has an extendable cutting blade that is pushed into the wellbore tubular to cut an opening through the tubular. The slot cutting tool may have an extendable stabilizing arm to stabilize and assist with cutting by the blade. The slot cutting assembly may have azimuth and depth sensors to assist with positioning the tool at a desired position downhole. A surface system may be used to control the position of the slot cutting assembly downhole.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present invention is related to an inhibitor or antagonist of SHP2 for the treatment and/or prevention of a neoplastic disease.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: An intrusion detection system and methods thereof are provided. In exemplary embodiments, the system may comprise an upper scanner adapted to create a first detection layer; a lower scanner adapted to create a second detection layer, the second detection layer overlapping the first detection layer; signal lighting for producing a visual signal; at least one server adapted analyze data received from the upper scanner and the lower scanner to determine if an object is in the path of the vehicle; and wherein the at least one server is adapted to activate the signal lighting when it is determined by the server that an object is in the path of the vehicle.

Abstract: An electrical instrument swivel connector has a first housing part and a second housing part rotatably connected to each other. The connection enabling transfer of axial loading between the housing parts. A first insulator body is rotatably engaged with a second insulator body and respectively sealingly engageable with an interior surface of the first housing part and the second housing part. Electrical contact pins are formed into the first insulator body and the second insulator body. The electrical contact pins each terminate in a separate electrical contact wherein the first insulator body rotatably engages the second insulator body. A biased electrical contact is disposed between each respective separate electrical contact in the first insulator body and the second insulator body.

Abstract: An electrical instrument swivel connector has a first housing part and a second housing part rotatably connected to each other. The connection enabling transfer of axial loading between the housing parts. A first insulator body is rotatably engaged with a second insulator body and respectively sealingly engageable with an interior surface of the first housing part and the second housing part. Electrical contact pins are formed into the first insulator body and the second insulator body. The electrical contact pins each terminate in a separate electrical contact wherein the first insulator body rotatably engages the second insulator body. A biased electrical contact is disposed between each respective separate electrical contact in the first insulator body and the second insulator body.