Patents by Inventor David Enscore
David Enscore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11369498Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.Type: GrantFiled: January 26, 2011Date of Patent: June 28, 2022Assignee: MT Acquisition Holdings LLCInventors: James B. McClain, Douglas Taylor, David Enscore
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Patent number: 10493254Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: GrantFiled: June 24, 2017Date of Patent: December 3, 2019Assignee: Nitto Denko CorporationInventors: Frank Tagliaferri, Alan Smith, David Enscore, Gaurav Tolia, Mirek Baudys
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Publication number: 20190117947Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: ApplicationFiled: June 24, 2017Publication date: April 25, 2019Applicant: Nitto Denko CorporationInventors: Frank Tagliaferri, Alan Smith, David Enscore, Gaurav Tolia, Mirek Baudys
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Patent number: 10166378Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: GrantFiled: October 28, 2013Date of Patent: January 1, 2019Assignee: NITTO DENKO CORPORATIONInventors: Frank Tagliaferri, Alan Smith, David Enscore, Gaurav Tolia, Mirek Baudys
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Patent number: 9498609Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: GrantFiled: September 29, 2010Date of Patent: November 22, 2016Assignee: NITTO DENKO CORPORATIONInventors: Frank Tagliaferri, Alan Smith, David Enscore, Gaurav Tolia, Mirek Baudys
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Publication number: 20140052051Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: ApplicationFiled: October 28, 2013Publication date: February 20, 2014Applicant: NITTO DENKO CORPORATIONInventors: FRANK TAGLIAFERRI, ALAN SMITH, DAVID ENSCORE, GAURAV TOLIA, MIREK BAUDYS
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Publication number: 20110190688Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.Type: ApplicationFiled: September 29, 2010Publication date: August 4, 2011Inventors: Frank Tagliaferri, Alan Smith, David Enscore, Gaurav Tolia, Mirek Baudys
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Publication number: 20110190864Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.Type: ApplicationFiled: January 26, 2011Publication date: August 4, 2011Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor, David Enscore
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Publication number: 20070031495Abstract: Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.Type: ApplicationFiled: June 19, 2006Publication date: February 8, 2007Inventors: Jonathan Eppstein, David Enscore, Frank Tagliaferri, Gaurav Tolia, Shulun Chang, Alan Smith, Yogi Patel, Stuart McRae
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Publication number: 20050249799Abstract: An oral delivery system for Class II drugs that have low oral bioavailability due to their insolubility in water and slow dissolution kinetics and method for making such a drug delivery system are disclosed herein. The formulation may be a controlled release or immediate release formulation. The immediate release formulation contains a Class II drug, together with a hydrophobic polymer, preferably a bioadhesive polymer. In one embodiment, the drug and polymer are co-dissolved in a common solvent. The solution is formed into small solid particles by any convenient method, particularly by spray drying. The resulting particles contain drug dispersed as small particles in a polymeric matrix. The particles are stable against aggregation, and can be put into capsules or tableted for administration. The controlled release formulations contain a BCS Class II drug and a bioadhesive polymer. The controlled release formulations may be in the form of a tablet, capsules, mini-tab, microparticulate, or osmotic pump.Type: ApplicationFiled: March 3, 2005Publication date: November 10, 2005Inventors: Jules Jacob, Michael Bassett, Marcus Schestopol, Edith Mathlowitz, Avinash Nangia, Bennett Carter, Peyman Moslemy, Ze'ev Shaked, David Enscore, Courtney Sikes
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Publication number: 20050064027Abstract: Bioadhesive macrosphere delivery systems (“BDDS”) having prolonged gastric retention time due to bioadhesion rather than physical density or size are described. In general, the macrospheres have diameters that are greater than 200 microns, more preferably greater than 500 microns. The bioadhesive macrospheres are released in the stomach where they reside in close proximity to the gastric mucosa for a prolonged period of time. Increased residence of BDDS in the upper GI can lead to increased systemic absorption of drug in the preferred site of systemic absorption, namely the upper GI tract (upper to mid-jejunum). The BDDS may be engineered either as a capsule with drug delivery controlled by a diffusion-limited membrane or degradable shell, or as a solid matrix system with drug delivery controlled by a combination of diffusion and polymer degradation kinetics.Type: ApplicationFiled: December 13, 2002Publication date: March 24, 2005Inventors: Jules Jacob, Edith Mathiowitz, David Enscore, Marcus Schestopol
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Publication number: 20030147965Abstract: A process for preparing nanoparticles, microparticles and nanoencapsulated products using the PIN process is provided. The invention involves using additives to reduce the aggregation or coalescence of the PIN nanoparticles, microparticles, or nanoencapsulated products during their formation and collection and to facilitate the recovery of said nanoparticles, microparticles, or nanoencapsulated products.Type: ApplicationFiled: December 10, 2002Publication date: August 7, 2003Applicant: Spherics, Inc.Inventors: Michael Bassett, Jules Jacob, David Enscore