Patents by Inventor David Epstein

David Epstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220059224
    Abstract: A next-best-action system includes real-time operation and off-line training and processes. During off-line training databases of medical conditions and associated diagnostic factors, tests and treatments are used to create models used for later natural language processing of input electronic text. Diagnostic factors are ranked according to the probability that they indicate conditions and are stored in a matrix. Treatments corresponding to conditions are also stored in a matrix. During real-time operation electronic text is received from patient history of an EHR system, from a transcribed conversation between a physician and a patient, or from input that the physician makes in the EHR system or in an overlaid diagnostic user interface. The electronic text is processed by an NLP pipeline that derives clinical diagnostic factors and test results for the patient.
    Type: Application
    Filed: August 19, 2021
    Publication date: February 24, 2022
    Inventors: Carl Bate TULLEY, Robert Derward ROGERS, Jennifer May LEE, David A. EPSTEIN, Michelle S. KELLER, Wian STIPP, David ROBINSON, Matthew MCSORLEY
  • Publication number: 20210332361
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: March 12, 2021
    Publication date: October 28, 2021
    Applicant: ARCHEMIX LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Publication number: 20210186538
    Abstract: Devices for loading intravascular treatment devices into a sheath and associated systems and methods are disclosed herein. A sheathing tool may include, for example, a first channel extending to a first opening, the first channel configured to receive a treatment device in a constrained state therethrough. The treatment device may include an elongated member and a first element and a second element at a distal region of the elongated member. The second channel may extend to a second opening, the second opening surrounded by a sidewall and configured to receive the treatment device in the constrained state therethrough, wherein the second opening is spaced apart from the first opening by a gap, and wherein a length of the gap is great enough to allow the first element to self-expand over the sidewall while the second element generally maintains its diameter in the constrained state while crossing the gap.
    Type: Application
    Filed: March 4, 2021
    Publication date: June 24, 2021
    Inventors: Evan David Epstein, Joseph Marrocco, David G. Matsuura, Philip J. Simpson, Jeffrey J. Loos, Adam Hattan
  • Patent number: 10947544
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: March 16, 2021
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Patent number: 10945746
    Abstract: Devices for loading intravascular treatment devices into a sheath and associated systems and methods are disclosed herein. A sheathing tool may include, for example, a first channel extending to a first opening, the first channel configured to receive a treatment device in a constrained state therethrough. The treatment device may include an elongated member and a first element and a second element at a distal region of the elongated member. The second channel may extend to a second opening, the second opening surrounded by a sidewall and configured to receive the treatment device in the constrained state therethrough, wherein the second opening is spaced apart from the first opening by a gap, and wherein a length of the gap is great enough to allow the first element to self-expand over the sidewall while the second element generally maintains its diameter in the constrained state while crossing the gap.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: March 16, 2021
    Assignee: COVIDIEN LP
    Inventors: Evan David Epstein, Joseph Marrocco, David G. Matsuura, Philip J. Simpson, Jeffrey J. Loos, Adam Hattan
  • Patent number: 10383644
    Abstract: The medical device can comprise a manipulation member, a mechanical thrombectomy apparatus attached to a distal end of the manipulation member, and flow-restricting apparatus attached to the manipulation member to a location proximal to the mechanical thrombectomy apparatus. A method, for retrieving thrombus from a blood vessel, can comprise advancing a single elongate delivery member carrying a mechanical thrombectomy apparatus and a flow-restricting apparatus through a catheter to the blood vessel, expanding the thrombectomy apparatus and capturing the thrombus with the thrombectomy device, expanding the flow-restricting apparatus to at least partially occlude blood flow toward the thrombus, retracting at least a portion of the thrombectomy apparatus into the flow-restricting apparatus, and retracting the flow-restricting apparatus and the thrombectomy apparatus into the retrieval catheter.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: August 20, 2019
    Assignee: Covidien LP
    Inventors: Masoud Molaei, Evan David Epstein, Garrett Johnson, Ghislain Sema
  • Publication number: 20190185858
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 20, 2019
    Applicant: ARCHEMIX LLC
    Inventors: CLAUDE BENEDICT, DAVID EPSTEIN, CHARLES WILSON, DILARA MCCAULEY, JEFFREY KURZ, MARKUS KURZ, THOMAS GREENE MCCAULEY, JAMES ROTTMAN
  • Publication number: 20180353196
    Abstract: Devices for loading intravascular treatment devices into a sheath and associated systems and methods are disclosed herein. A sheathing tool may include, for example, a first channel extending to a first opening, the first channel configured to receive a treatment device in a constrained state therethrough. The treatment device may include an elongated member and a first element and a second element at a distal region of the elongated member. The second channel may extend to a second opening, the second opening surrounded by a sidewall and configured to receive the treatment device in the constrained state therethrough, wherein the second opening is spaced apart from the first opening by a gap, and wherein a length of the gap is great enough to allow the first element to self-expand over the sidewall while the second element generally maintains its diameter in the constrained state while crossing the gap.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 13, 2018
    Inventors: Evan David Epstein, Joseph Marrocco, David G. Matsuura, Simpson J. Philip, Loos J. Jeffrey, Adam Hattan
  • Patent number: 10100316
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: October 16, 2018
    Assignee: Archemix LLC
    Inventors: David Epstein, Dilara Grate, Martin Stanton, John L. Diener, Charles Wilson, Thomas Greene McCauley, Errol Desouza
  • Patent number: 10098657
    Abstract: A device for intravascular intervention can comprise an intervention element and an elongate manipulation member. The elongate member can comprise a hooked portion extending about a proximal portion of the intervention element. The hooked portion can have a first segment, a second segment, and a bend between the first and second segments, with the first segment and the second segment located on different sides of the intervention element. At least one of the first segment or the second segment can have an extending portion that extends into a region that is (i) between a top side and a bottom side of the intervention element, and (ii) distal to a proximal part of the intervention element. The extending portion and the proximal part can be aligned such that a line extending in a proximal-distal direction intersects the extending portion and the proximal part.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: October 16, 2018
    Assignee: Covidien LP
    Inventors: Michael Louis Losordo, Masoud Molaei, John Wainwright, Evan David Epstein
  • Publication number: 20180030446
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: March 2, 2017
    Publication date: February 1, 2018
    Applicant: ARCHEMIX LLC
    Inventors: Claude BENEDICT, David EPSTEIN, Charles WILSON, Dilara MCCAULEY, Jeffrey KURZ, Markus KURZ, Thomas Greene MCCAULEY, James ROTTMAN
  • Publication number: 20180008718
    Abstract: Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as ECA or a derivative thereof, for an effective period of time.
    Type: Application
    Filed: January 19, 2016
    Publication date: January 11, 2018
    Applicants: The Johns Hopkins University, Duke University
    Inventors: Jie Fu, Justin Hanes, Molly Walsh, David Epstein
  • Pen
    Patent number: D890844
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: July 21, 2020
    Inventor: David A. Epstein
  • Pen
    Patent number: D919006
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: May 11, 2021
    Assignee: Spec.MFG LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D923091
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: June 22, 2021
    Assignee: Spec.MFG LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D925652
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: July 20, 2021
    Assignee: GMG Pen LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D925653
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: July 20, 2021
    Assignee: GMG Pen LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D925654
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: July 20, 2021
    Assignee: GMG Pen LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D925655
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 20, 2021
    Assignee: GMG Pen LLC
    Inventor: David A. Epstein
  • Pen
    Patent number: D925656
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 20, 2021
    Assignee: GMG Pen LLC
    Inventor: David A. Epstein