Abstract: Surface enhanced Raman scattering (SERS) substrates may be fabricated using a shadow mask assisted evaporation (SMAE) method to provide for enhanced detection sensitivity with respect to target molecules that are located upon, and sensitized by, the SERS enhanced substrates. Such SERS substrates provide a two dimensional array of repeating nanostructures that may include, but are not limited to nano-pillar, nano-nib, nano-elliptical cylinder and nano-triangular tip nanostructures, any of which may be augmented with gold nanospheres. The particular SERS enhanced substrates in accordance with the embodiments, in particular when augmented with gold nanospheres, provide desirably enhanced sensitivity.

Abstract: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: A method and/or system are described in which a server communicatively coupled with a set-top-box (STB) may predict a location of a pointer on a web browser running on the STB. The server may render the pointer based on the predicted pointer location. The server may send the rendered pointer to the STB, wherein the STB may composite a web page on the web browser based on the rendered pointer. The server may be synchronized with the STB based on event information received by the server from the STB such as, for example, keystroke events, click event, or other like event. The prediction of the pointer location may be based on actual pointer location information provided by the STB. A predetermined number of pointer locations may be predicted based on an actual pointer location and/or on a latency of a connection between the server and the STB.

Abstract: Methods and systems for colorimetric detection of a target. Nucleic acid is obtained from a sample potentially containing two pathogens of interest, and is contacted with a plurality of nanoparticles. A first portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the first target and oligonucleotides complementary to a second region of the first target, and a second portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the second target and oligonucleotides complementary to a second region of the second target. The presence of the target nucleic acid causes a detectable colorimetric change, thereby diagnosing the presence of the pathogen.

Abstract: Presented herein are systems, methods, and apparatus for improving performance of video decoders during rewind and fast forward operation. Video decoder performance is improved by avoiding repetitive decoding of prediction pictures. When a decoded prediction picture is stored in a frame buffer, techniques are presented for decoding multiple pictures in the rewind order which are dependent thereon, displaying the picture directly from the frame buffer, and setting one type of prediction picture as another type of prediction picture.

Abstract: A device determines a portion of data generated by a technical computing environment (TCE) program, where the portion of the data is determined based on an initial availability of a resource of a server device. The device provides the portion of the data to the server device for execution, and receives, from the server device, results associated with execution of the portion of the data. The device calculates an availability of the resource based on the results associated with execution of the portion of the data, and provides, to the server device for execution, additional data generated by the TCE program, where the additional data is determined based on the availability of the resource of the server device. The device receives, from the server device, results associated with execution of the additional data, where the receiving is performed by the device.

Abstract: Methods and systems are described for providing complete Internet anywhere with partial server processing in which a request is sent from a set-top-box (STB) to a server communicatively coupled with the STB to process a portion of a web page that is unsupported by a web browser running on the STB. In one such method, the STB sends to the server an unsupported content request associated with a portion of a web page that is unsupported by a web browser executing on the STB. The STB receives a data stream from the server in response to the unsupported content request. The data stream was generated at the server by processing the unsupported portion of the web page. The STB composites the received data stream with another portion of the web page, that is supported by the web browser, to produce the web page.

Abstract: A method and apparatus are provided for a secure interconnect between data modules, including a security apparatus within a secured data interconnect apparatus installed with a security chip. The interconnect apparatus may be authenticated prior to enabling a stacking feature. Authentication of a interconnect apparatus may be used to ensure the quality and performance of the interconnect apparatus and the data modules.

Abstract: A reconfigurable optofluidic apparatus includes a microfluidic chip including a microfluidic channel further including an inlet for a liquid core waveguide fluid; a channel pathway for the liquid core waveguide fluid; a plurality of non-core waveguide fluid inlets; a switching chamber having a larger cross sectional area than the channel pathway; and an outlet for the liquid core waveguide fluid and non-core waveguide fluid, further including a plurality of non-liquid core waveguides disposed in the switching chamber. Light input to the apparatus propagates in the liquid core/liquid cladding (liquid) waveguide. The path of the liquid waveguide can be steered in a region of the apparatus over one of the non-liquid core waveguides such that the light is end-fire- or evanescently-coupled into the non-liquid core waveguide and output therefrom or between two of the non-liquid core waveguides and not coupled or output. Associated optofluidic switching methods are disclosed.

Abstract: A processor for a cable television set-top box has an interface for coupling the processor to a second processor. The processor also has a port that is coupleable to control a tuner, a demodulator and a DOCSIS module with or without DSG support. The tuner has an output coupled to the demodulator input, and the demodulator has an output to the DOCSIS module input. The demodulator's output is also coupled to a conditional access module controlled by the second processor. The processor issues commands via the port to control at least one of the tuner and the demodulator based on instructions received via the interface from the second processor.

Abstract: Disclosed is a high resolution intravascular ultrasound imaging system including a catheter with a rotatable imaging assembly and an image processor. The image processor in turn features a pulser configured to energize the ultrasound transducer of the rotatable imaging assembly with a multi-frequency ultrasound waveform signal. The image processor further contains a receiver configured to decompose received ultrasound energy as reflected by the target vessel into a plurality of individual subband signals, individually process these signals and reconstitute these signals into a high resolution image of the blood vessel. The IVUS system of the invention may be useful in characterizing cap thickness of vulnerable plaques or other detailed studies of blood vessels.

Abstract: The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.

Abstract: This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula wherein R1 to R10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: A server may be used to handle at least some of processing of content retrieved via and/or derived from Internet access operations of a plurality of set-top boxes (STBs). Resource allocation and/or utilization, and/or tasks or applications performed in the server during the processing may be configured based on control data, which may be determined by the server and which may comprise capabilities of links between the server and each of the plurality of STBs, requirements of the tasks, characteristics of the content and/or the Internet access operations, user preferences and/or interactions, and/or content provider preferences. The server may dynamically reconfigure the tasks and/or resources based on monitoring of its operations and/or changes of the control data. Configuring tasks and/or resources may comprise time slicing access to resources that are commonly used during concurrent servicing of at least some of the plurality of STBs by the support server.

Abstract: This invention relates to novel 1,2-pyridazines, 1,6-pyridazines or pyrimidines of the formula wherein B1 to B3 and R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.

Abstract: This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: Methods and systems are described for providing complete Internet anywhere with partial server processing in which a request is sent from a set-top-box (STB) to a server communicatively coupled with the STB to process a portion of a web page that is unsupported by a web browser running on the STB. In one such method, the STB sends to the server an unsupported content request associated with a portion of a web page that is unsupported by a web browser executing on the STB. The STB receives a data stream from the server in response to the unsupported content request. The data stream was generated at the server by processing the unsupported portion of the web page. The STB composites the received data stream with another portion of the web page, that is supported by the web browser, to produce the web page.

Abstract: Disclosed are various embodiments that facilitate fast switching of synchronized media using time-stamp management. A first media stream and multiple second media streams are obtained. The second media stream is time synchronized to the first media stream. The first media stream and one of the second media streams are decoded. Time-stamp management without decoding is performed for another one of the second media streams to facilitate fast switching to the other one of the second media streams when desired.

Abstract: Methods and systems are described for providing complete Internet anywhere with partial server processing in which a request is sent from a set-top-box (STB) to a server communicatively coupled with the STB to process a portion of a web page that is unsupported by a web browser running on the STB. In one such method, the STB sends to the server an unsupported content request associated with a portion of a web page that is unsupported by a web browser executing on the STB. The STB receives a data stream from the server in response to the unsupported content request. The data stream was generated at the server by processing the unsupported portion of the web page. The STB composites the received data stream with another portion of the web page, that is supported by the web browser, to produce the web page.

Abstract: A set top box or like device incorporating an untrusted software framework as a client of a secure operating system kernel. The software framework may comprise, for example, an Android framework supported by an underlying Linux operating system environment having a secure kernel. The software framework can be executed using a variety of process isolation techniques depending on performance and isolation requirements. A secure access client/server interface may also be provided to support interactions between the untrusted software framework (and applications utilizing the untrusted software framework) and secure or trusted portions of the device. The secure access interface can be configured to perform operations such as handle validation, heap pointer validation, non-pointer parameter validation, heap isolation, and resource release relating to terminated processes.