Patents by Inventor David Esopi

David Esopi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family
    Patent number: 11479802
    Abstract: Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 25, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Panayiotis Stevis, David Esopi, Jesper Gromada, Jorge Haller, Yashu Liu, Andrew Murphy, William Olson
  • Compositions and Methods for Treatment of Disorders Associated with Repetitive DNA
    Publication number: 20220186216
    Abstract: Compositions and methods for treating excising trinucleotide repeats, as well as for treating diseases and disorders associated with trinucleotide repeats are encompassed.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 16, 2022
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gregoriy Aleksandrovich Dokshin, Matthias Heidenreich, Norzehan Abdul-Manan, Lu Gan, Jianming Liu, Guoxiang Ruan, Jesper Gromada, John Patrick Leonard, Zachary Michael Detwiler, Peter Thomas Hallock, David Esopi, Giselle Dominguez Gutierrez
  • Assays For Screening Activity Of Modulators Of Members Of The Hydroxysteroid (17-Beta) Dehydrogenase (HSD17B) Family
    Publication number: 20180291422
    Abstract: Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.
    Type: Application
    Filed: March 6, 2018
    Publication date: October 11, 2018
    Inventors: Panayiotis Stevis, David Esopi, Jesper Gromada, Jorge Haller, Yashu Liu, Andrew Murphy, William Olson