Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.

Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.

Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.

Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.

Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.

Abstract: The present invention relates to peptides, peptide analogs and peptide derivatives related to platelet factor 4 which exhibit anti-inflammatory activity, to pharmaceutical compositions comprising said peptides, and to methods of inhibiting inflammation utilizing the peptides of the invention.

Abstract: A composition of matter useful for enhancing the metabolism of the skin and mucosal tissue and thereby improving its health and appearance. The composition of matter includes a lipidic furan and retinol palmitate. The lipidic furan has a structure: furan--R, wherein R is a straight C.sub.9-36 alkyl chain, having the formula CH.sub.3 --(CH.sub.2).sub.n --(CH.sub.2).sub.n CH.sub.3, (n=8 to 35). R can also be a straight unsaturated C.sub.9-36 alkenyl chain with a single double bond, of the formula --(CH.sub.2).sub.n --CH.dbd.CH--(CH.sub.2).sub.m --CH.sub.3, wherein n and m.noteq.0 and n+m=6 to 33. R can be a straight unsaturated C.sub.9-36 chain, containing two to six double bonds, with the formula CH.sub.3 --(CH.sub.2).sub.m --(CH.dbd.CH).sub.x --(CH.sub.2).sub.n --, wherein m, x and n.noteq.0, m+2x+n=8 to 35. R can likewise be a straight unsaturated C.sub.9-36 chain containing one to six double bonds and one triple bond, having the formula CH.sub.3 --(CH.sub.2).sub.m --C.tbd.C--(CH.dbd.CH--CH.sub.2).sub.

Abstract: A composition of matter useful for enhancing the metabolism of the skin and mucosal tissue and thereby improving its health and appearance. The composition of matter has the furan (2)--R, wherein R is a straight C.sub.9--36 alkyl chain, having the formula CH.sub.3 --(CH.sub.2).sub.n --(CH.sub.2).sub.n CH.sub.3, (n=8 to 35). R can also be a straight unsaturated C.sub.9-36 alkenyl chain with a single double bond, of the formula --(CH.sub.2).sub.n --CH.dbd.CH--(CH.sub.2).sub.m --CH.sub.3, wherein n and m.noteq.0 and n+m32 6 to 33. R can be a straight unsaturated C.sub.9-36 chain, containing two to six double bonds, with the formula CH.sub.3 --(CH.sub.2).sub.m --(CH.dbd.CH).sub.x --(CH.sub.2).sub.n --, wherein m, x and n .noteq.0, m+2x+n=8 to 35. R can likewise be a straight unsaturated C.sub.9-36 chain containing one to six double bonds and one triple bond, having the formula CH.sub.3 --(CH.sub.2).sub.m --C.tbd.C--(CH.dbd. CH--CH.sub.2).sub.x --, wherein m and x.noteq.0 and m+3x=6 to 33.