Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: The present invention provides an apparatus and method for processing and viewing mail. The apparatus provides a structure for maintaining an environment for processing and viewing mail that is separate from the user so that if the mail is contaminated with biological material the contamination remains separate from the user processing and viewing the mail and contained within the apparatus. The apparatus includes glove box like enclosure for receiving mail, wherein at least one member of the glove box like enclosure is transparent. The apparatus includes gloves attached to glove ports, wherein the gloves allow a user to access and view the mail contained therein while still remaining separate from the environment of the glove box like enclosure.

Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Abstract: Apparatus for providing price indication of articles selected for purchase prior to actual purchase embodies a system having a reader for reading article UPC indication and generating output signals indicative thereof, a comparator for receipt of the reader output signals and for providing at least first and second output signals upon respective determinations that such received signals are indicative of an article retailed by bulk weight pricing or an article retailed per piece pricing, a scale accessible to a customer for weighing the articles and generating output signals indicative of the weight thereof, a numeric entry unit accessible to a customer for entering the numbers of pieces of the selected articles and generating output signals indicative of such entered numbers, and a display accessible to the customer and responsive to the first and second comparator output signals respectively to provide indication to the customer for usage of the scale or the numeric entry unit.

Abstract: A system is provided for the operator-unassisted checkout of articles, inclusive of bulk articles, typically of the nature of produce or the like, wherein supermarket personnel or a customer applies a UPC label to the bulk articles upon selection, as distinguished from the normal instances wherein the article bears a "source-applied" UPC indication, e.g., as in the case of source-packaged goods. Price computation is effected for the bulk articles by scanning of the UPC indication and use of price per unit weight or price per piece derived from storage responsively to the scanning. The article measured weight or the numbers of the article are used respectively in computation of price for the selected bulk article.

Abstract: The present invention relates to a package for objects such as batteries, and more particularly for the display and sale of large, heavy cell sizes, such as "C" size and "D" size alkaline cells. The transparent package, having a rectangularly shaped perimeter similar to conventional two-cell packages, contains four such cells in diamond-shaped arrangement.

Abstract: A photopolymerizable monomer comprising a lipid having at least one hydrophobic acyl chain containing at least two conjugated acetylenic linkages is useful in preparing radiation-sensitive compositions and photographic elements comprising a plurality of liposomes. Further, processes for photopolymerizing the radiation-sensitive compositions and for forming an image in the photographic elements comprise exposing the lipid to radiation, heating the lipid to a temperature equal to or above a first transition temperature of the lipid to render it insensitive to further exposure, and optionally cooling the lipid to a temperature equal to or below a seocnd phase transition temperature of the lipid to render it again sensitive to further exposure. The monomeric lipids, when photopolymerized, form polymeric lipids exhibiting decreased solubility and liposome wall permeability as compared to the unpolymerized monomeric lipids.

Abstract: The present invention relates to a package for objects such as batteries, and more particularly for the display and sale of large, heavy cell sizes, such as "C" size and "D" size alkaline cells. A transparent package containing four such cells is provided having a similar outside rectangular shape as conventional two-cell packages.

Abstract: Vesicles comprising a matrix of lipid membranes prepared from lipid materials are useful in biomedical studies and immunoassays. A labeled species is encapsulated within the vesicles and released when the vesicles are lysed with a surface active agent. The outer surface of the vesicles is essentially free of the labeled species. Immunoassays can be carried out in solution or with a dry analytical element.

Abstract: The (+), (-) and (.+-.) forms of the compounds of the general formula (I) ##STR1## characterized in that R.sup.1 is a halo group; or a lower alkyl, lower alkoxy or lower alkylthio group, each of which may be substituted with one or more halo groups;R.sup.2 is hydrogen or a methyl group; or R.sup.1 and R.sup.2 together form a methylenedioxy, or a difluoromethylenedioxy group or, with the carbon atoms to which they are attached, an aromatic or heteroaromatic ring; andA is one of the groups X or Y ##STR2## wherein X.sup.1 and X.sup.2 are the same or different and each is hydrogen or a fluoro, chloro, bromo or methyl group, with the proviso that if X.sup.1 is a fluoro group, then X.sup.2 should not be a bromo group; and X.sup.3 and X.sup.4 are the same or different and each is hydrogen or a fluoro group; andY.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo, chloro, or methyl group.The compounds (I) are insecticidally active.

Abstract: A light-sensitive composition comprising:(1) a plurality of vesicles comprising lipid membranes containing rhodopsin;(2) a mixture of enzymes comprising phosphodiesterase and GTPase;(3) a first nucleotide capable of interacting with GTPase to form a cofactor necessary for the activation of phosphodiesterase;(4) at least one metal cation selected from the group consisting of Mg.sup.+2 and Mn.sup.+2 ; and(5) a second nucleotide capable of being hydrolyzed to produce a proton, said hydrolysis reaction being catalyzed by activated phosphodiesterase, said phosphodiesterase also being activated by rhodopsin exposed by light in the presence of said cofactor and said metal cationis useful in preparing photographic elements comprising means for detecting the hydrolysis reaction, such as an indicator dye.

Abstract: Compounds of the general formula I ##STR1## wherein R.sup.1 is hydrogen or a methoxy, ethoxy, propoxy, butoxy, tetrafluoroethoxy, methylthio, ethylthio, propylthio, fluoro, chloro, bromo, methyl, ethyl, or nitro group, and R.sup.2 is hydrogen or a methyl group, orR.sup.1 and R.sup.2 together form a methylenedioxy group;R.sup.3 is hydrogen, or a lower alkyl group, or one of the following groups (a) to (f):(a) 3-phenoxybenzyl(b) 2-benzyl-4-furylmethyl(c) .alpha.-cyano-3-phenoxybenzyl(d) 3,4-methylenedioxybenzyl(e) .alpha.-ethynyl-3-phenoxybenzyl(f) .alpha.-cyano-3-(4'-chlorophenoxy)-benzyland Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo or chloro group, with the proviso that when R.sup.1 is hydrogen, fluoro, chloro, bromo or methyl and R.sup.2 is hydrogen, then one of Y.sup.1 to Y.sup.6 is other than hydrogen.The compounds in which R.sup.3 is one of groups (a) to (f) are insecticides.

Abstract: Compounds of the general formula I ##STR1## wherein R.sup.1 is hydrogen or a methoxy, ethoxy, propoxy, butoxy, tetrafluoroethoxy, methylthio, ethylthio, propylthio, fluoro, chloro, bromo, methyl, ethyl, or nitro group, and R.sup.2 is hydrogen or a methyl group, or R.sup.1 and R.sup.2 together form a methylenedioxy group; R.sup.3 is hydrogen, or a lower alkyl group, or one of the following groups (a) to (f):(a) 3-phenoxybenzyl(b) 2-benzyl-4-furylmethyl(c) .alpha.-cyano-3-phenoxybenzyl(d) 3,4-methylenedioxybenzyl(e) .alpha.-ethynyl-3-phenoxybenzyl(f) .alpha.-cyano-3-(4'-chlorophenoxy)-benzyland Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo or chloro group, with the proviso that when R.sup.1 is hydrogen, fluoro, chloro, bromo or methyl and R.sup.2 is hydrogen, then one of Y.sup.1 to Y.sup.6 is other than hydrogen.The compounds in which R.sup.3 is one of groups (a) to (f) are insecticides.

Abstract: Compounds of the general formula I ##STR1## wherein R.sup.1 is hydrogen or a methoxy, ethoxy, propoxy, butoxy, tetrafluoroethoxy, methylthio, ethylthio, propylthio, fluoro, chloro, bromo, methyl, ethyl, or nitro group, and R.sup.2 is hydrogen or a methyl group, or R.sup.1 and R.sup.2 together form a methylenedioxy group;R.sup.3 is hydrogen, or a lower alkyl group, or one of the following groups (a) to (f):(a) 3-phenoxybenzyl(b) 2-benzyl-4-furylmethyl(c) .alpha.-cyano-3-phenoxybenzyl(d) 3,4-methylenedioxybenzyl(e) .alpha.-ethynyl-3-phenoxybenzyl(f) .alpha.-cyano-3-(4'-chlorophenoxy)-benzyland Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.6 are the same or different groups and each is hydrogen or a fluoro, bromo or chloro group, with the proviso that when R.sup.1 is hydrogen, fluoro, chloro, bromo or methyl and R.sup.2 is hydrogen, then one of Y.sup.1 to Y.sup.6 is other than hydrogen.The compounds in which R.sup.3 is one of groups (a) to (f) are insecticides.