Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: An apparatus for removing a biologically active agent from body fluid that includes an inlet for receiving body fluid, a substrate that includes the reaction product of a substantially water insoluble polymer and a polyalkylene imine, the polyalkylene imine being in a form capable of binding a biologically active agent in the body fluid, and an outlet through which the body fluid flows following contact with the substrate.

Abstract: A process for modifying a surface of an article that includes treating a surface with a solution that includes an organic solvent, and the reaction product of a substantially water insoluble polymer and a polyalkylene imine to form a modified surface.

Abstract: A dispenser for dispensing products such as liquid antimicrobials is described. The dispenser includes a bracket/actuator assembly and a container assembly. The dispenser includes a novel mechanism for attaching the container assembly to the bracket/actuator assembly and also includes a novel valve assembly.

Abstract: A drip resistant nozzle for a dispenser is described. The drip resistant nozzle includes a flexible, resilient member that moves between several positions during actuation of the dispenser.

Abstract: A liquid applicator is provided which is particularly useful in applying preoperative surgical scrubs or paints to skin. The liquid is contained in a frangible ampoule inside the body of the applicator. This ampoule is supported and protected by a deformable element that prevents unintentional breakage of the ampoule from impacts during storage and handling before use. The applicator is actuated by pushing at least a portion of the frangible ampoule through an aperture in the deformable element and into contact with a means for breaking the ampoule.

Abstract: A liquid applicator is provided which is particularly useful in applying preoperative surgical scrubs or paints to skin. The liquid is contained in a frangible ampoule inside the body of the applicator. This ampoule is supported and protected by a deformable element that prevents unintentional breakage of the ampoule from impacts during storage and handling before use. The applicator is actuated by pushing at least a portion of the frangible ampoule through an aperture in the deformable element and into contact with a means for breaking the ampoule.

Abstract: An assembly for insertion into the cardiovascular system of a patient comprising a catheter having first and second lumens and a distal port. The first lumen opens at the distal port. A probe is received in the second lumen. The probe includes a sensor responsive to a constituent of blood for providing a signal which is related to the constituent. The catheter has a window for allowing the constituent of blood to pass from outside the catheter to the sensor while substantially preventing other constituents of blood from passing from the outside of the catheter to the sensor.

Abstract: A liquid applicator is provided which is particularly useful in applying preoperative surgical scrubs or paints to skin. The liquid is contained in a frangible ampoule inside the body of the applicator. This ampoule is supported and protected by a deformable element that prevents unintentional breakage of the ampoule from impacts during storage and handling before use. The applicator is actuated by pushing at least a portion of the frangible ampoule through an aperture in the deformable element and into contact with a means for breaking the ampoule.

Abstract: A thermal atherectomy catheter has a tip of high magnetic permeability cylindrical stem with an enlarged head at one end and an enlarged collar at the other end, a coil of wire wrapped about the stem adjacent the head and removed from said collar, a sleeve of ferromagnetic material disposed about the coil and a second sleeve of non-magnetic outer sleeve extending between and of the diameter of the head and collar to define a space between the sleeves whereby the outer sleeve to collar are maintained at a lower temperature than the head.

Abstract: A catheter is provided with a heated temperature self regulating tip for insertion in an artery to ablate an atherosclerotic plaque obstruction particularly in coronary and peripheral arteries. The heater is located at the distal end of the catheter and has a winding of fine wire around a ferro-magnetic core with the wire being connected via a transmission line to a high frequency constant alternating current source in the megahertz range. The catheter which may or may not employ a guide wire is inserted into and through the lumen of a vessel and guided usually with the assistance of fluoroscopy to the location of the stenosis. The heater is energized to ablate the plaque, the temperature not exceeding a desired temperature as determined by the Curie temperature of the ferromagnetic material.

Abstract: A liquid applicator as provided which is particularly useful in applying pre-operative surgical scrubs or paints to skin. The article is provided with an inner layer of porous metering material and an outer layer of open-cell foam sponge material which regulate the flow of liquid therethrough to provide acceptable wetting of the foam sponge while preventing dripping therefrom. The applicator includes an air vent spaced from the applicator head to allow air to flow into the applicator while liquid is being dispensed.This is a continuation of application Ser. No. 904,788, filed Sept. 4, 1986, now abandoned, which is a continuation-in-part of Ser. No. 798,989, filed 11/18/85, now abandoned.

Abstract: An evaporative humidifier having a float operated relief mechanism that is normally air tight, and will release excess water from the humidifier, should the water inlet valve malfunction, to preclude liquid water from getting into the stream of air being humidified.