Patents by Inventor David Feld

David Feld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10451402
    Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: October 22, 2019
    Assignees: Massachusetts Institute of Technology, Hamamatsu Photonics K.K.
    Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Patent number: 9662047
    Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: May 30, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Jonathan Feld, David Feld, Alison Hearn, Chae-Ryon Kong, Jeon Woong Kang
  • Patent number: 9433351
    Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 6, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20150177133
    Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
    Type: Application
    Filed: September 18, 2014
    Publication date: June 25, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Alison Hearn, David Feld, Jonathan Feld
  • Publication number: 20140361148
    Abstract: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 11, 2014
    Inventors: Jonathan Feld, David Feld, Alison Hearn
  • Publication number: 20130265585
    Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology.
    Type: Application
    Filed: December 14, 2012
    Publication date: October 10, 2013
    Inventors: David Feld, Jonathan Feld, Alison Hearn
  • Publication number: 20120307035
    Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.
    Type: Application
    Filed: January 25, 2012
    Publication date: December 6, 2012
    Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20120302892
    Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
    Type: Application
    Filed: December 28, 2011
    Publication date: November 29, 2012
    Inventors: Niyom Lue, Michael Feld, Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20120259228
    Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
    Type: Application
    Filed: May 4, 2012
    Publication date: October 11, 2012
    Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20120172940
    Abstract: Several embodiments are provided for a modular therapeutic garment having electrodes integral with the garment and treatment permitted by such garment. The therapeutic garment can comprise a compression knit fabric material, and an array of electrodes integral with the compression knit fabric material. The compression knit fabric material can exert pressures within a range including values suitable for clinical treatment. The array of electrodes can be arranged to overlie specific portions of a subject, such as muscle groups or other body parts. Each electrode of the array of electrode can be formed of a conductive knit fabric material. The conductive knit fabric material can enclose a liquid absorptive material. A method for treating a musculoskeletal dysfunction with the therapeutic garment also is provided. The method also can be effective at improving musculoskeletal condition of healthy subjects.
    Type: Application
    Filed: November 30, 2011
    Publication date: July 5, 2012
    Inventors: Terry L. Wahls, Richard Shields, Ryan David Feld
  • Publication number: 20120035442
    Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
    Type: Application
    Filed: June 23, 2011
    Publication date: February 9, 2012
    Inventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Chae-Ryon Kong, David Feld, Alison Hearn, Jonathan Feld
  • Publication number: 20070236310
    Abstract: An electronic device. The electronic device includes a first electrode and a coating layer. The electronic device is fabricated on a substrate; the substrate has a cavity created in a top surface of the substrate; and the first electrode is electrically coupled to the substrate. The coating layer coats at least part of a substrate surface in the cavity, and the presence of the coating layer results in a mitigation of at least one parasitic leakage path between the first electrode and an additional electrode fabricated on the substrate.
    Type: Application
    Filed: March 10, 2006
    Publication date: October 11, 2007
    Inventors: R. Fazzio, Richard Ruby, Christopher Wade, Michael Frank, David Feld
  • Patent number: 5866069
    Abstract: Material that is to be used in wrapping medical items or in making gowns, drapes, and the like is treated with silicone to make it liquid repellent. The material, after being sterilized by an oxidizing plasma process, still retains its repellency.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: February 2, 1999
    Assignee: Johnson & Johnson Medical Inc.
    Inventors: Toby A. Soto, David Feld, Xiaolan Chen
  • Patent number: 4643180
    Abstract: An adhesive surgical dressing with an antimicrobial agent in the adhesive is disclosed. The antimicrobial agent is a salt of polyhexamethylene biguanide and is applied to the surface of the adhesive to a depth of not more than 50% of the thickness of the adhesive.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: February 17, 1987
    Assignee: Surgikos, Inc.
    Inventors: David Feld, Toby A. Soto