Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method for manufacturing/producing a dental restoration for a patient, where the method includes: obtaining a 3D scan of at least a restoration site of the patient's mouth, where the manufactured dental restoration is adapted for fitting to the restoration site; obtaining a computer-aided design (CAD design) of the dental restoration; milling the restoration from a material, where the restoration is milled both on an inside surface configured for fitting to the shape of the restoration site of the patient's mouth and on an outside surface, where the milling is according to the obtained CAD design; transferring the milled restoration to a retention means providing a fixed known position of the restoration relative to a post-processing machinery, where the restoration is retained on the inside surface, such that the outside surface of the restoration is approachable/free/accessible; and performing post-processing of the outside surface of the restoration.

Abstract: An electric driven hydraulic fracking system is disclosed. A pump configuration that includes the single VFD, the single shaft electric motor, and the single hydraulic pump that is mounted on the single pump trailer. A pump configuration includes a single VFD configuration, the single shaft electric motor, and the single shaft hydraulic pump mounted on the single pump trailer. The single VFD configuration converts the electric power at the power generation voltage level distributed from the power distribution trailer to a VFD voltage level and drives the single shaft electric motor to control the operation of the single shaft electric motor and the single hydraulic pump. The VFD voltage level is a voltage level that is required to drive the single shaft electric motor. The VFD configuration also controls operation of the auxiliary systems based on the electric power at the auxiliary voltage level.

Abstract: An anti-fouling composition, and uses thereof in the industrial preparation of ethylenically unsaturated monomers comprising at least one heteroatom, such as acrylic monomers are disclosed.

Abstract: Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles.

Abstract: Disclosed are devices and methods for optimizing a protective helmet or other item of protective clothing with one or more enhanced principal impact zones and/or impact elements that incorporate protective features that can be particularized to a specific player-position and/or the individual behavior of a specific player or wearer.

Abstract: Aspects of the subject disclosure may include, for example, receiving workload requests for tenant devices providing services to user devices; partitioning node resources to facilitate network slicing in a software defined network to provide the services; determining that the workload requests exceed available resources of the node; and outsourcing a portion of a load to one or more neighboring nodes, where the outsourcing is performed in coordination with a regional orchestrator and a SDN intelligence module. Other embodiments are disclosed.

Abstract: The invention relates to novel compounds of the formula (I) in which X, R1, R2, R3, V and n have the meanings given above, to the use thereof as acaricides and/or insecticides for controlling animal pests and to methods and intermediates for the preparation thereof.

Abstract: An example method may include obtaining operational instructions for operation of an autonomous tractor system to perform an agricultural task within an operational environment and directing the operational instructions to the autonomous tractor system. The method may also include while the autonomous tractor system is autonomously performing the agricultural task per the operational instructions, obtaining a notification that the autonomous tractor system is experiencing an unexpected event. The notification may provide an indication of the event and multiple responses performable by the autonomous tractor system in response to the event. In response to the notification, the method may include obtaining, based on input from a user, a selection of one of the multiple responses and directing the selected one of the multiple responses to the autonomous tractor system.

Abstract: A mechanical device for cooling an electronic component may include a surface including an aperture, and a first support protruding from the surface and a second support protruding from the surface. In some embodiments, the device may include disposed within the aperture a thermal interface material (TIM).

Abstract: A method for manufacturing/producing a dental restoration for a patient, where the method includes: obtaining a 3D scan of at least a restoration site of the patient's mouth, where the manufactured dental restoration is adapted for fitting to the restoration site; obtaining a computer-aided design (CAD design) of the dental restoration; milling the restoration from a material, where the restoration is milled both on an inside surface configured for fitting to the shape of the restoration site of the patient's mouth and on an outside surface, where the milling is according to the obtained CAD design; transferring the milled restoration to a retention means providing a fixed known position of the restoration relative to a post-processing machinery, where the restoration is retained on the inside surface, such that the outside surface of the restoration is approachable/free/accessible; and performing post-processing of the outside surface of the restoration.

Abstract: A method for dynamically adjusting a number of virtual machines for a workload, includes: receiving a probability indicator for each of a plurality of N sequential stages, where N is a natural number greater than 1, of a likelihood that a virtual machine assigned to a workload will be evicted during the N sequential stages; predicting a target number of virtual machines to configure in a current stage for a subsequent stage from among the plurality of N sequential stages based on the probability indicator, a target capacity for the workload, and a current price for maintaining a virtual machine; and configuring a number of virtual machines for the workload during the current stage based on the target number to be loaded for the workload for the subsequent stage.

Abstract: A shunt 200 for treating glaucoma in a patient during and/or after vitreoretinal surgery involving the use of a tamponading agent comprising a gas or oil bubble 50. The shunt includes a tubular body 12 having a proximal end 14 which is implantable in the vitreous cavity C of a patient and a distal end which is implantable in the subarachnoid space of the patient. The tubular body defines a lumen 18 extending between the distal and proximal ends. The shunt includes an occlusion body 32 defining a number of micro-passages 34 inflow communication with the lumen 18. The micro-passages are configured in terms of their size and number to provide sufficient surface tension and viscosity resistance in order to prevent the tamponading agent from passing through the micro-passages into the lumen, yet allow sufficient aqueous fluid from the vitreous cavity to travel along the micro-passages into the lumen 18 in order to regulate intraocular pressure.

Abstract: A mechanical device for cooling an electronic component may include a surface including an aperture, and a first support protruding from the surface and a second support protruding from the surface. In some embodiments, the device may include disposed within the aperture a thermal interface material (TIM).

Abstract: A connector for a networking cable assembly includes a substrate, a first set of contacts on a first surface of the substrate that electrically connect to leads of a first cable, and a second set of contacts on the first surface of the substrate that electrically connect to leads of a second cable. The first set of contacts are spaced apart from the second set of contacts in a first direction by an amount that enables the second cable to be stacked on the first cable and passed over the first set of contacts to electrically connect to the leads of the second cable.

Abstract: A fluid level sensor system is disclosed for sensing a fluid level in a well. The system has a main body and an inlet housing coupled to the main body. The inlet housing has an internal chamber in communication with an ambient environment within the well. A bellows within the main body communicates with the internal chamber of the inlet housing. A movable element is responsive to movement of the bellows. A sensor detects when the movable element moves from a first position, indicating a first fluid level in the well, to a second position indicating a second fluid level within the well. An indicator is operably associated with the movable element and moves into a position to be viewable when the sensing element is moved to the second position, to provide a visual indication that the second fluid level has been reached.

Abstract: A connector for a networking cable assembly includes a substrate, a first set of contacts on a first surface of the substrate that electrically connect to leads of a first cable, and a second set of contacts on the first surface of the substrate that electrically connect to leads of a second cable. The first set of contacts are spaced apart from the second set of contacts in a first direction by an amount that enables the second cable to be stacked on the first cable and passed over the first set of contacts to electrically connect to the leads of the second cable.

Abstract: Various embodiments concern a pneumatic landfill pump cycle counter comprising a spring located within a housing passage and a shuttle comprising a shuttle magnet, the shuttle located within the passage. The shuttle can be configured to move axially by the spring within the passage in an upstream direction to a home position, move axially by one or both of air pressure differential and airflow within the passage in a downstream direction away from the home position to a hold position. The cycle counter can further comprise a counter comprising an element responsive to a magnetic field of the shuttle magnet, the counter configured to increment a numeric count for each complete cycle of the shuttle moving from the home position to the hold position and then back to the home position.

Abstract: A service latch assembly for a vehicle is disclosed. The latch assembly includes a striker member and a latch mechanism configured to selectively engage and release the strike member. The latch mechanism includes a frame plate defining a guideway configured to receive the striker member, a striker guard inserted into the guideway, a latch member pivotally connected to the frame plate, a stop tab extending from a closed end of the guideway, a stop bumper inserted onto the stop tab, and an over-mold fitted over the latch member. The over-mold includes a pivot limiter bumper configured to cooperate with the stop bumper to limit the pivot of the latch member in an open position and a striker retention feature nested onto an edge retention surface of a first lever arm of the latch member.

Abstract: A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.