Patents by Inventor David FitzGerald

David FitzGerald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200316201
    Abstract: The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the HAO1 gene, and methods of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1.
    Type: Application
    Filed: November 4, 2019
    Publication date: October 8, 2020
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • Patent number: 10768210
    Abstract: A device for detecting stray electrical currents in fluid mediums comprises at least two probes for partially disposing in a fluid medium and a control unit. The control unit comprises at least one analog-to-digital signal converter in electrical communication with at least one of the probes, at least one audio-visual alarm, and a processor operably coupled to the at least one converter and to the at least one audio-visual alarm. The processor is operable to measure an electrical potential difference between the two probes, to analyze a plurality of the measurements to determine whether a predetermined frequency is present, and to transmit an alert signal to the audio-visual alarm if the predetermined frequency is present. Advantageously, by monitoring for the frequency, the device more consistently and more reliably detects the presence of stray alternating currents.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: September 8, 2020
    Assignee: Marine Co. Systems, LLC
    Inventors: Matthew Bruce Fitzgerald, Arnar Thors, Roger Alan Miller, John David Cook, Daniel James Myers
  • Publication number: 20200236557
    Abstract: A method for monitoring performance of Cooperative Periodic Activity between Spectrum Access Systems, CPAS, process in a network operating Citizens Broadband Radio Service, CBRS. The method comprises performing a first check of a status of a transmission Grant of a Citizens Broadband Radio service Device, CBSD at the start of the CPAS process and if the result of the first check indicates that the Grant is suspended then performing a second check of the status of said transmission Grant at the end of the CPAS process. The method further comprises raising an alarm if the result of the second check indicates that the Grant is suspended. An apparatus and a network implementing the method are also disclosed.
    Type: Application
    Filed: December 12, 2019
    Publication date: July 23, 2020
    Inventors: Simon Richardson, Mapfumo Chidzambwa, Pedro Henrique De Oliveira Mota, Nicholas Fitzgerald, Andru M. Mac Giolla Ri, Don McCarthy, Mayke Nespoli, Denis O'Connor, David O'Shaughnessy, Bujji Krishna Raju Babulingam, Yang Zhao
  • Publication number: 20200206258
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting expression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.
    Type: Application
    Filed: March 6, 2020
    Publication date: July 2, 2020
    Inventors: David Erbe, Abigail Liebow, Kevin Fitzgerald, Gregory Hinkle, Kyle David Wood, Ross Philip Holmes, John Knight
  • Publication number: 20200184864
    Abstract: An animated window system may include a projection surface configured to display at least one image to a viewer on a viewer side of the projection surface, wherein the projection surface comprises a tinted material. The animated window system may also include a projector spaced apart from the projection surface, wherein the projector is configured to project the at least one image onto a rear side of the projection surface, the rear side opposing the viewer side and a controller comprising a memory and a processor, wherein the controller is configured to provide the at least one image to the projector to be projected onto the projection surface.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 11, 2020
    Inventors: Timothy Fitzgerald Garnier, Akiva Meir Krauthamer, Matthew Usi, Simran V. Batra, David Majdali
  • Publication number: 20200151665
    Abstract: A system is provided. The system includes a warehouse management server (WMS) for storing delivery order information and locations of items specified in each of a plurality of delivery orders. The system further includes a mobile device, in communication with the WMS, for enabling user interaction with the delivery order information and the locations of the items in real-time. The system also includes an optical scanner, in communication with the mobile device, for tracking (i) picked ones of the items and (ii) item totes containing the picked ones of the items. The WMS determines the picked ones of the items, the item totes containing the picked ones of the items, and item packages for the picked ones of the items, and sends directions displayed on the mobile device for picking and packing the picked one of the items in each of the plurality of delivery orders responsive to the determining.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Inventors: David Fitzgerald, Keith Rill
  • Publication number: 20200113927
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LDHA gene, as well as methods of inhibiting epression of LDHA, methods of inhibiting LDHA and HAO1, and methods of treating subjects that would benefit from reduction in expression of LDHA, such as subjects having an oxalate pathway-associated disease, disorder, or condition, using such dsRNA compositions.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 16, 2020
    Inventors: David Erbe, Abigail Liebow, Kevin Fitzgerald, Gregory Hinkle, Kyle David Wood, Ross Philip Holmes, John Knight
  • Publication number: 20200087322
    Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: May 17, 2017
    Publication date: March 19, 2020
    Inventors: Sarah Anna Liesa Johannes, Philipp Buchgraber, Ulrich Klar, Clara Christ, Kai Thede, Joachim Kuhnke, Manfred Moewes, Knut Eis, Amaury Fernandez-Montalvan, Nicolas Werbeck, Ursula Moenning, Philip Lienau, Ulrike Sack, Arne Scholz, Michael H. Serrano-Wu, Chris Lemke, David McKinney, Mark Fitzgerald, Christopher Nasveschuk, Kiel Lazarski, Steven James Ferrara, Laura Furst, Guo Wei, Patrick R. McCarren
  • Publication number: 20200068299
    Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.
    Type: Application
    Filed: October 29, 2019
    Publication date: February 27, 2020
    Applicant: Cirrus Logic International Semiconductor Ltd.
    Inventors: Ross Crawford MORGAN, Robert David RAND, Richard Colin FITZGERALD
  • Publication number: 20200052887
    Abstract: According to an example aspect of the present invention, there is provided a method, comprising: receiving an input ordered set of transactions after a genesis block or a preceding compressed block in a chain of blocks, generating a compressed block on the basis of the input ordered set of transactions, wherein processing of the compressed block results to an equivalent final state as processing of the input ordered set of transactions, and providing the compressed block to a distributed network for establishing a new chain epoch and replacing a set of uncompressed blocks associated with the input ordered set of transactions.
    Type: Application
    Filed: August 7, 2019
    Publication date: February 13, 2020
    Inventors: Edward FITZGERALD, Karina PALYUTINA, Enrique MARTIN LOPEZ, David BITAULD
  • Patent number: 10499147
    Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 3, 2019
    Assignee: Cirrus Logic, Inc.
    Inventors: Ross Crawford Morgan, Robert David Rand, Richard Colin Fitzgerald
  • Patent number: 10489725
    Abstract: A system and method for controlling business processes through information technology operational controls are disclosed. The method includes: receiving a business process; monitoring a load at each of multiple layers of the system; sending, to an end-to-end throttle controller, for each layer of the multiple layers, layer load data corresponding to the load at the layer, wherein each layer load data contains data related to a single layer; determining whether any adjustments should be made to throttling policies corresponding to the multiple layers based on the multiple layer load data; sending any adjustments that should be made to throttle agents of one or more layers; updating the throttling policies of one or more layers based on the adjustments; and, continuing executing the business process based on the updated throttling policies.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: November 26, 2019
    Assignee: Aetna Inc.
    Inventors: Claus T. Jensen, Robert Samuel, Gerald Cormier, David Fitzgerald
  • Patent number: 10478500
    Abstract: The invention relates to RNAi agents, e.g. double-stranded RNAi agents, targeting the HAO1 gene, and method of using such RNAi agents to inhibit expression of HAO1 and methods of treating subjects having, e.g., PH1. Described herein are double-stranded RNAi agents which inhibit the expression of a HA01 gene in a cell, such as a cell within a subject, e.g., a mammal, such as a human having a HAO1 associated disorder, and uses of such double-stranded RNAi agents. In certain aspects of the invention, substantially all of the nucleotides of an iRNA of the invention are modified.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 19, 2019
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: William Querbes, Kevin Fitzgerald, Brian Bettencourt, Abigail Liebow, David V. Erbe
  • Publication number: 20190290432
    Abstract: A prolapse prevention device formed by a continuous wire-like structure having a first end and a second end disconnected from each other. The continuous wire-like structure of the prolapse prevention device is substantially straight in a delivery configuration. The prolapse prevention device in a deployed configuration includes a centering ring of the continuous wire-like structure configured to seat adjacent to and upstream of an annulus of a heart valve in situ, a vertical support of the continuous wire-like structure which extends from the centering ring and includes an apex configured to seat against a roof of an atrium in situ, and a leaflet backstop of the continuous wire-like structure extending radially inward from the centering ring and configured to contact at least at least a first leaflet of the heart valve in situ to exert a pressure in a downstream direction on the first leaflet to prevent the first leaflet from prolapsing into the atrium.
    Type: Application
    Filed: March 14, 2019
    Publication date: September 26, 2019
    Inventors: Niall DUFFY, David FARASCIONI, Adam FITZGERALD, Nathan KNUTSON, Ana MENK, Aran MURRAY, Jay RASSAT
  • Patent number: 10388497
    Abstract: A portable ion mobility spectrometry apparatus (1) for detecting an aerosol and a method for using the apparatus. The apparatus comprises an ion mobility spectrometer (3); a portable power source (5) carried by the apparatus for providing power to the apparatus (1); an inlet (7) for collecting a flow of air to be tested by the spectrometer (3); a heater (4) configured to heat the air to be tested to vaporize an aerosol carried by the air and a controller (2) configured to control the spectrometer (3) to obtain samples from the heated air, wherein the controller is configured to increase a heat output from the heater (4) for a selected time period before obtaining samples from the heated air.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: August 20, 2019
    Assignee: SMITHS DETECTION-WATFORD LIMITED
    Inventors: David Sharp, Alastair Clark, William Munro, Paul Arnold, John FitzGerald, David Cutmore, Rod Wilson
  • Publication number: 20190209696
    Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc?RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc?RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient.
    Type: Application
    Filed: November 5, 2018
    Publication date: July 11, 2019
    Inventors: David A. Spiegel, Patrick McEnaney, Kelly Fitzgerald
  • Publication number: 20190189412
    Abstract: A portable ion mobility spectrometry apparatus (1) for detecting an aerosol and a method for using the apparatus. The apparatus comprises an ion mobility spectrometer (3); a portable power source (5) carried by the apparatus for providing power to the apparatus (1); an inlet (7) for collecting a flow of air to be tested by the spectrometer (3); a heater (4) configured to heat the air to be tested to vapourise an aerosol carried by the air and a controller (2) configured to control the spectrometer (3) to obtain samples from the heated air, wherein the controller is configured to increase a heat output from the heater (4) for a selected time period before obtaining samples from the heated air.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 20, 2019
    Inventors: David Sharp, Alastair Clark, William Munro, Paul Arnold, John Fitzgerald, David Cutmore, Rod Wilson
  • Patent number: 10324024
    Abstract: Embodiments relate generally to methods, systems, devices and applications for use in relation to the detection of chemical vapours. A particular embodiment relates to a device for chemical vapour sensing. The device comprises a housing of a size to be manually portable, the housing defining a plurality of receptors adapted to receive a respective plurality of manually replaceable chemical vapour sensing components. The device further comprises at least one signal receiver to receive data signals from each chemical vapour sensing component when the chemical vapour sensing component is positioned in one of the receptors.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: June 18, 2019
    Assignee: THE COMMONWEALTH OF AUSTRALIA
    Inventors: Karl David Pavey, Nicholas John Fitzgerald, Craig Jason Stevens, John Thomas Huberts, Anthony Andrew Pahl, Igor Henricus Van de Griendt
  • Patent number: 10299594
    Abstract: A tie bar for connecting two horizontal beams includes first and second elongate walls arranged parallel to each other, and a third elongate wall arranged perpendicular to the first and second elongate walls and coupled to a lateral side of each of the first and second elongate walls. The tie bar further includes at least one pair of hook elements positioned at terminal ends of at least one of the first, second, or third elongate walls. Each of the hook elements includes a depending tab configured to be received by an elongate slot of a horizontal beam of a shelving unit. The first and second elongate walls may be top and bottom walls, respectively, the third elongate wall may be a side wall, and the at least one pair of hook elements may include first and second hook elements positioned on the second elongate wall.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 28, 2019
    Assignee: Edsal Manufacturing Company, Inc.
    Inventors: Mitchell Liss, David J. Wojtowicz, Anthony J. Troyner, Jeff Lamber, Mitchell E. Bianchin, Scott Fitzgerald
  • Patent number: D859893
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: September 17, 2019
    Assignee: Edsal Manufacturing Company, Inc.
    Inventors: Scott Fitzgerald, David J. Wojtowicz, Thomas St. Germain, Mitchell Liss, Al Dunaj