Abstract: The present disclosure provides methods of treating cancer by inhibiting the FOXO1 pathway, such as by small molecular inhibitor or RNA interference. The methods may be used to treat aggressive cancers, such as glioblastoma and basal breast cancer. Further provided herein are combination therapies for the treatment of cancer.

Abstract: The low-penetrating particles low gain avalanche detector comprises a multi-layered structure and receives particles from a radiation source (13). It consists of a thin entry region that receives the particles from the radiation source (13); a low-penetrating particles detection region, with a p++ shallow field stop (1), positioned beneath the entry region, and a p absorption layer (3), positioned beneath the p++ shallow field stop (1), and an n multiplication layer (4); and a high-penetrating particles detection region positioned beneath the n multiplication layer (4), consisting of a n-- silicon substrate (5). Due to the chosen doping polarities, the primary electrons (created by the particles from the radiation source (13)) drift away from the entry region. That way, signals from low-penetrating particles or radiation experience amplification, while the noise is kept similar to a conventional PIN structure, thus increasing the signal-to-noise ratio.

Abstract: A ornamental writing utensil assembly includes a housing has a writing well therein to receive an elongated writing utensil. Additionally, the housing has a rod well therein. A mating member is coupled to the housing and the mating member releasably engages a support surface for storing the housing. A rod is insertable into the rod well and a pair of wings that each movably engages the rod to enhance the ornamental appearance of the writing utensil. A plurality of couplers is each coupled to a respective one of the wings. Each of the couplers movably engages the rod for retaining each of the wings on the rod.

Abstract: A ornamental writing utensil assembly includes a housing has a writing well therein to receive an elongated writing utensil. Additionally, the housing has a rod well therein. A mating member is coupled to the housing and the mating member releasably engages a support surface for storing the housing. A rod is insertable into the rod well and a pair of wings that each movably engages the rod to enhance the ornamental appearance of the writing utensil. A plurality of couplers is each coupled to a respective one of the wings. Each of the couplers movably engages the rod for retaining each of the wings on the rod.

Abstract: A spark erosion machine includes a frame with a space for spark erosion of a workpiece, a wire for cutting by spark erosion, and a wire guide head for guiding the wire across the workpiece, so as to detach an offcut from it; an offcut support mounted movably relative to the guide head, the support being configured to move at least between a retention position under the spark erosion space, where it can collect the offcut, and a retracted position; and an offcut extractor.

Abstract: A spark erosion machine includes a frame with a space for spark erosion of a workpiece, a wire for cutting by spark erosion, and a wire guide head for guiding the wire across the workpiece, so as to detach an offcut from it; an offcut support mounted movably relative to the guide head, the support being configured to move at least between a retention position under the spark erosion space, where it can collect the offcut, and a retracted position; and an offcut extractor.

Abstract: Components and methodology for producing custom-sized, small aluminum modular chassis based on a single design and production process is disclosed. The unique designs of the components and the modularity of the design allow for the cost-effective production of varying size chassis. A broad range of chassis sizes can be produced without the need to modify the production setup and can be produced with basic, relatively inexpensive machinery. All components and extrusion profiles are unique to the design and assembly of the chassis.

Abstract: A method for submitting and receiving information required for tax filing contains a mobile interface and a website interface. A client submits information through the mobile interface. Personal information and digital photographs of at least one identification card and received tax documentation are submitted by the client through a client account. Required tax information is extracted from the digital photographs submitted by the client account. The personal information and the required tax information are stored on a secure server. A tax preparer accesses the secure server through a tax preparer account. More specifically, the tax preparer account accesses the secure server through the website interface. When the personal information and the required tax information are reviewed and edited by the tax preparer account, the tax preparer account can proceed with the tax filing process through the website interface.

Abstract: The present invention relates to polyene macrolide derivatives according to the formula: wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

Abstract: A method of monitoring vibratory phenomena that occur in an aviation gas turbine engine in operation includes establishing a frequency spectrum of a vibratory signal representative of the operating state of the engine and of its components; using a plurality of vibratory signatures, each corresponding to a vibratory phenomenon that occurs during operation of aeroengines of the same type as the engine being monitored and originating from a defect in or an abnormal operation of a component of the engines; identifying, in the spectrum, the points of curves that match mathematical functions, each defining a vibratory signature; and for each identified curve corresponding to a defect of engine components, analyzing the amplitude associated with the points of the curve relative to predefined amplitude values corresponding to a degree of severity of the defect; and as a result of an amplitude value being exceeded or an abnormal operation being detected, issuing a message associated with the vibratory signature.

Abstract: Grouped computing device configuration management systems and methods are described herein.

Abstract: An exercise training device in the form of a baseball bat or other sports-related equipment that has been modified to have dual handles. The device is adapted to be attached to a weight resistance system in order to perform abdominal exercises while doing baseball or other sports-related motions and plyometric movements.

Abstract: The invention relates to a method and a system for monitoring vibratory phenomena that occur in an aviation gas turbine engine in operation.

Abstract: An actuator device includes a pole piece and at least one magnet for generating a magnetic field. A coarse positioner having a coil surrounding the pole piece provides coarse actuation in a direction parallel to an axis of the pole piece. A fine positioner having a coil surrounding the pole piece provides fine actuation in a direction generally parallel to an axis of the pole piece.

Abstract: In the method, the following are placed in succession on a substrate: at least one conductive layer and at least one semiconductor power circuit, and metal connection tabs are fitted to the face of the semiconductor circuit facing away from the conductive layer by metallizing a metal film. Thereafter, at least one solder element is placed on each film obtained in this way, at least one conductive member is applied to the or each solder element on its side facing away from the metal film, and the or each solder element is caused to melt so as to secure the or each conductive member to the or each metal film.

Abstract: A process for the early detection of a possible fault in a rotary component of an engine wherein a signal representing an acceleration is stored in a sequential manner; the stored signal is transformed into a frequency signal a spectral coherence calculation is performed between said frequency signal and the same frequency signal shifted by frequency values predetermined as a function of the speed of the engine; the sequences are counted for which a correlation peak appears for one of the predetermined frequencies and a fault is deemed to be present if for a number P of consecutive sequences the number of sequences with a correlation peak is greater than a predetermined threshold.

Abstract: In the method, the following are placed in succession on a substrate: at least one conductive layer and at least one semiconductor power circuit, and metal connection tabs are fitted to the face of the semiconductor circuit facing away from the conductive layer by metallizing a metal film. Thereafter, at least one solder element is placed on each film obtained in this way, at least one conductive member is applied to the or each solder element on its side facing away from the metal film, and the or each solder element is caused to melt so as to secure the or each conductive member to the or each metal film.

Abstract: A method and apparatus for sampling an analog signal permits the identification of those samples in which data was lost in the sampling process. A data reference element is generated for each sample element, the data reference element having a corresponding sample element. A user friendly display technique is provided to permit the user to controllably display the sampled signal, clearly showing those portions of the signal in which information was lost contrasted with those portions of the signal that were sampled intact.

Abstract: A method and apparatus for sampling an analog signal permits the identification of those samples in which data was lost in the sampling process. A data reference element is generated for each sample element, the data reference element having a corresponding sample element. A user friendly display technique is provided to permit the user to controllably display the sampled signal, clearly showing those portions of the signal in which information was lost contrasted with those portions of the signal that were sampled intact.

Abstract: A method and system for the efficient distribution of electronic mail items within a distributed data processing system having multiple users enrolled therein wherein each user utilizes a computer or terminal device having a unique address. After selecting an individual electronic mail item for distribution an intuitive graphic representation of a group of unique addresses is displayed within a user's terminal device. The intuitive graphic representation may take one of several forms including a two or three dimensional graphic representation of an office floor plan which identifies the occupants of each office, or a photographic image of one or more users. In response to a graphic selection by the user of a particular graphic representation, or portion thereof, an identified electronic mail item is then automatically distributed to the user whose unique address is associated with that graphic representation or portion thereof.