Abstract: In one aspect, an aerosol provision system is provided. The system includes an assembly defining an opening configured to receive a replaceable consumable and a removable member releasably engaged with the assembly. The removable member is configured to form part of an outer surface of the system, and is positioned so as not to obstruct the opening.

Abstract: A system for tethering a subsea blowout preventer (BOP) or well head is disclosed. In at least one embodiment, the system comprises an interface associable with the BOP, and more than one anchors disposed about the BOP. Each anchor is configured to carry or support a tensioning system arranged in operable association with a respective tether. Each tether is arranged so as to link a respective anchor with a respective operable means associated with the BOP. Furthermore, each of the respective operable means are configured in operable association with the interface such that tension in the tethers can be adjustable either individually or together as a group of two or more tethers, by way of the interface.

Abstract: The method of manufacturing an integrated circuit includes obtaining a silicon carbide substrate of a first conductivity type having an epitaxial layer of a second conductivity type thereon. A dopant is implanted in the epitaxial layer to form a first region of the first conductivity type that extends the full depth of the epitaxial layer. A first transistor is formed in the first region and a second transistor is formed in the epitaxial layer.

Abstract: The method of manufacturing an integrated circuit includes obtaining a silicon carbide substrate of a first conductivity type having an epitaxial layer of a second conductivity type thereon. A dopant is implanted in the epitaxial layer to form a first region of the first conductivity type that extends the full depth of the epitaxial layer. A first transistor is formed in the first region and a second transistor is formed in the epitaxial layer.

Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.

Abstract: The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Abstract: A rotor (3a . . . 3c) for an electrical machine (1) is described which comprises several rotor segments (10a . . . 10c, 10a?, 10a?, 10 . . . 10??) which are arranged successively along the rotational axis (x) of the rotor (3a . . . 3c) and each comprise a rotor plate (11) or several rotor plates (11). Magnetic poles (A . . . D) of two adjacent rotor segments (10a . . . 10c, 10a?, 10a?, 10 . . . 10??) are twisted relative to one another around the rotational axis (x) of the rotor (3a . . . 3c) by a staggering angle (?), wherein the staggering angle (?) is smaller than a polar angle (?) lying between two magnetic poles (A . . . D) of a rotor segment (10a . . . 10c, 10a?, 10a?, 10 . . . 10??). The rotor (3a . . . 3c) comprises at least two first cutouts (12) which are arranged on a first hole circle (L1) around the rotational axis (x) of the rotor (3a . . . 3c) and are each twisted relative to one another by an angle (?) which corresponds to the polar angle (?) minus or plus the staggering angle (?).

Abstract: The silo safety system implements safety logic for silo opening gates by utilizing light sensors connected to a programmable logic controller or equivalent configuration of relay contact switches. Photodetection sensors and their associated light transmitters are placed on opposing lateral sides along a truck passageway under the silos where the tail, middle, and front of a truck are presupposed to be. When a truck pulls under the silos, system logic uses the resultant pattern of beam breaks to prevent the silo gates from opening unless the truck cab is clear from the silo that the truck is supposed to be under. For two or more silos, the system enables only the correct silo, while the other silos are disabled. The silo that the truck is under can then only be energized by the silo control operator. The control logic can have a default configuration for a predetermined truck size.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. The preferred delivery device includes a catheter having a deployment mechanism attached to its distal end, and a handle mechanism attached to its proximal end. A plurality of tethers are provided to selectively restrain the valve during deployment. A number of mechanisms for active deployment of partially expanded prosthetic valves are also described.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. The preferred delivery device includes a catheter having a deployment mechanism attached to its distal end, and a handle mechanism attached to its proximal end. A plurality of tethers are provided to selectively restrain the valve during deployment. A number of mechanisms for active deployment of partially expanded prosthetic valves are also described.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. The preferred delivery device includes a catheter having a deployment mechanism attached to its distal end, and a handle mechanism attached to its proximal end. A plurality of tethers are provided to selectively restrain the valve during deployment. A number of mechanisms for active deployment of partially expanded prosthetic valves are also described.

Abstract: A mobile router is configured for attaching to a selected router in a clustered network (e.g., a mobile ad hoc network) based on identifying a network topology model of the clustered network from received router advertisement messages that include tree information option fields specifying attributes of the network topology model. The mobile router selects which router advertisement originator to attach to based on correlating the attributes of the router advertisement originators relative to identified priorities, and orders the router advertisement originators within a default router list based on the identified priorities. If the mobile router detects a router from a second clustered network, the mobile router advertises to the attachment router that the second clustered network is reachable, enabling the two clustered networks to communicate using a point-to-point link between the respective attachment routers.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Abstract: Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Abstract: Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery using a catheter, and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The stents may include an annulus section, a sinus section with the membranes attached over sinus apertures, and an outflow section. Lockout tabs and making slots secure the stents in their expanded shapes. Alignment structure ensures concentric unfurling of the stent. Anchoring elements at the stent edges or in the stent body secure the valve within the annulus. A method of manufacture includes shape setting the sheet-like stent to ensure an outward bias during deployment. The stent may also include dear tracks for engagement with a gear mechanism for deployment.

Abstract: The invention provides an apparatus and method for manipulating parts of the body in surgical procedures, particularly useful for peritoneal distension in laparoscopic surgery. The apparatus comprises a positionable support structure having an extendible horizontal arm rotatably mounted to an extendible vertical post, the post having a clamp at its lower end for mounting to a surgical table. An end segment at the distal end of the horizontal arm has a mount for mounting end-of-arm tooling, for example, peritoneal distension instruments. Locking mechanisms are disposed in the horizontal arm, vertical post and end segment to lock the support structure in a desired position. A motor is disposed within the vertical post for power-assisted extension and retraction of the vertical post. Preferably, the locking mechanisms and motor are controllable using switches mounted on the end segment.

Abstract: The invention provides an apparatus and method for manipulating parts of the body in surgical procedures, particularly useful for peritoneal distension in laparoscopic surgery. The apparatus comprises a positionable support structure having an extendible horizontal arm rotatably mounted to an extendible vertical post, the post having a clamp at its lower end for mounting to a surgical table. An end segment at the distal end of the horizontal arm has a mount for mounting end-of-arm tooling, for example, peritoneal distension instruments. Locking mechanisms are disposed in the horizontal arm, vertical post and end segment to lock the support structure in a desired position. A motor is disposed within the vertical post for power-assisted extension and retraction of the vertical post. Preferably, the locking mechanisms and motor are controllable using switches mounted on the end segment.

Abstract: An auxiliary artificial heart which comprises a pump having a single opening that is connected to the aorta and is operable in synchronism with the heart of the patient to assist the normal function of the heart. The auxiliary artificial heart comprises a housing having the single opening therein and a diaphragm which is movable toward and away from the opening by a rotating reversible electric stepping motor. Rotation of the motor rotates circumferentially spaced roller pins which extend radially inwardly into engagement with a helical groove of a screw attached to the diaphragm such to translate the screw and move the diaphragm toward and away from the opening. The housing is sealed to enclose a gas in the housing such that the differential pressure caused by movement of the screw assists the diaphragm in its movement.