Abstract: The present disclosure provides systems and methods for providing geographic information for software application development. In one example, a computer-implemented method is provided for determining candidate locations for a playability service, which includes obtaining, by one or more computing devices, a plurality of location points and filtering the plurality of location points to obtain a plurality of candidate location points based at least in part on a suitability of each of the location points for use in generating location-based application content. The method further includes generating, by the one or more computing devices, a candidate location dataset based on the plurality of candidate location points. The method further includes receiving, by the one or more computing devices, a request for one or more of the plurality of candidate location points and providing data associated with one or more of the plurality of candidate location points in response to the request.

Abstract: A system and process for dynamic security monitoring of test taking. The system combines historical information about the test taker or relevant conditions, and includes sensors which objectively monitor test taker's actions, inactions, and involuntary response to the test given before and during the test, and at a specific test location. The information collected from the sensors is compared to a plurality of predetermined individual risk factors, which indicate a possibility of test fraud by the individual test taker to create a test event risk profile. The individual risk profile is combined with non-individual specific risk factors to create a holistic test event security profile. Security resources are then dynamically assigned to or removed from the test event based on the unique test event security profile.

Abstract: The present invention provides methods of testing anti-STn antibodies for their ability target cancer stem cells by isolating cancer stem cells from cultures, contacting them with anti-STn antibodies being tested, and measuring resulting cell viability.

Abstract: Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells.

Abstract: A heart valve implantation device with a motor and drive mechanism that allows a single operator to deliver a prosthetic heart valve to a target site. The motor controls relative positions between a delivery catheter and an implant release mechanism attached to the implant. The motor can be operated in two directions, allowing the motor to be used not only for delivery, but for loading and extraction of the valve, if necessary. An embodiment of a valve implant and a loading system designed for use with the device are also described.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame having a first arm and a second arm extending from the base of the clamp frame. The second arm is moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame; clamp jaws including a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp a rib web to a rib post or clamp a rib web to a rib foot. The first jaw and/or second jaw includes a contact normalisation system, the contact normalisation system including: a jaw body fixed relative to the respective arm.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame having a first arm and a second arm extending from the base of the clamp frame. The second arm is moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame; clamp jaws including a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp an aircraft assembly. One of the jaws includes a tool module docking aperture into which a tool module is insertable for accessing the aircraft assembly; and a swarf channel extending into the tool module docking aperture, the swarf channel fluidically connected to a vacuum source and configured to extract waste material adjacent the aircraft assembly.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame, a first arm and a second arm extending from the base of the clamp frame, the second arm is moveably mounted to the base of the clamp so as to be moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame. The clamp jaws include a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp the rib web to the rib post or rib foot. One of the clamp jaws defines a tool module docking aperture configured to receive a tool module for providing access to the rib web and rib post or rib foot clamped between the clamp jaws.

Abstract: Systems and methods for automated extrusion of main elements for building construction are disclosed wherein sub-components of sub-elements are extruded by automated means, and sub-elements are assembled by automated means, and the sub-elements are incorporated into main elements by automated means.

Abstract: The disclosure provides amino acid sequence variants of Botulinum neurotoxin (BoNT) proteases that cleave (VAMP1, VAMP2, VAMP7, VAMP8, SNAP25, SNAP23, PTEN, etc.) and methods of evolving the same. In some embodiments, proteases described by the disclosure are useful for cleaving proteins found in a cell, that is in an intracellular environment. In some embodiments, proteases described by the disclosure are useful for treating diseases associated with increased or aberrant VAMP7, VAMP8, SNAP23 or PTEN expression or activity, for example, cancer and neurological disorders. Some aspects of this disclosure provide methods for generating BoNT protease variants by continuous directed evolution.

Abstract: User access to a physical location (e.g., a homes, businesses, or other locations) may be granted for certain limited tasks based on one or more access procedures stored in a registry and associated with an identity of the user. Such access may be given without including an interaction with an owner, administrator, or manager of the location. User individuals may self-identify themselves to an access server or registry after arriving at the premises and receive corresponding access privileges via one or more devices within the premises based on access procedures stored in the access registry. The access procedures may be executed by the access server through communications with access devices within or about the premises and may be tailored based on the type of user individual or type of access requested.

Abstract: Systems and processes are provided for analyzing a test taker's knowledge, skills, and cognitive function. The systems and processes include smart questions (i.e., SmartItems) programmed with coded variables, or for multiple choice varieties, variable sets of options to cover an entire skill set being tested. The systems and processes generate questions in real time during administration of the test, by formulating and displaying, to a test taker, random combinations of a question stem and randomly-selected question components. This smart question content is unpredictably and randomly presented, as representations of the skill to be tested. The systems and processes analyze the test taker's knowledge, skills, and cognitive function about the entire domain of the skill, rather than a single fact. The systems and processes provide security to test administration.

Abstract: Systems and processes are provided for analyzing a test taker's knowledge, skills, and cognitive function. The systems and processes include smart questions (i.e., SmartItems) programmed with coded variables, or for multiple choice varieties, variable sets of options to cover an entire skill set being tested. The systems and processes generate questions in real time during administration of the test, by formulating and displaying, to a test taker, random combinations of a question stem and randomly-selected question components. This smart question content is unpredictably and randomly presented, as representations of the skill to be tested. The systems and processes analyze the test taker's knowledge, skills, and cognitive function about the entire domain of the skill, rather than a single fact. The systems and processes provide security to test administration.

Abstract: An offshore renewable energy system mounting platform is provided for positioning a renewable energy converter in a body of water. The platform includes a frame having a first structural member and a second structural member that are positioned adjacent one another at a mating connection and at least one mooring member affixed to the frame at a tethering location which is tethers the frame to a bed of the body of water. Either the first or second structural members comprises a buoyancy and a tension in the mooring member is arranged to counteract the buoyancy to urge the first and second structural members together at the mating connection. The platform may be manufactured as a set of pre-fabricated modular components which are subsequently assembled into the complete platform.

Abstract: A system and process for dynamic security monitoring of test taking. The system combines historical information about the test taker or relevant conditions, and includes sensors which objectively monitor test taker's actions, inactions, and involuntary response to the test given before and during the test, and at a specific test location. The information collected from the sensors is compared to a plurality of predetermined individual risk factors, which indicate a possibility of test fraud by the individual test taker to create a test event risk profile. The individual risk profile is combined with non-individual specific risk factors to create a holistic test event security profile. Security resources are then dynamically assigned to or removed from the test event based on the unique test event security profile.

Abstract: A firearm retention mechanism is provided for a holster. The device comprises first and second arms that each have a first end and a second end, outwardly extending retention elements and trigger guard stops, and a fastener which connects the first and second arms so that they define an open top, with the retention elements and trigger guard stops facing one another, the trigger guard stops located below the retention elements. The arms are connected to sides of the holster with the open top facing upwardly to receive a trigger guard of the firearm, which is then pressed between the retention elements.

Abstract: A system and process for dynamic security monitoring of test taking. The system combines historical information about the test taker or relevant conditions, and includes sensors which objectively monitor test taker's actions, inactions, and involuntary response to the test given before and during the test, and at a specific test location. The information collected from the sensors is compared to a plurality of predetermined individual risk factors, which indicate a possibility of test fraud by the individual test taker to create a test event risk profile. The individual risk profile is combined with non-individual specific risk factors to create a holistic test event security profile. Security resources are then dynamically assigned to or removed from the test event based on the unique test event security profile.

Abstract: Systems and processes are provided for analyzing a test taker's knowledge, skills, and cognitive function. The systems and processes include smart questions (i.e., SmartItems) programmed with coded variables, or for multiple choice varieties, variable sets of options to cover an entire skill set being tested. The systems and processes generate questions in real time during administration of the test, by formulating and displaying, to a test taker, random combinations of a question stem and randomly-selected question components. This smart question content is unpredictably and randomly presented, as representations of the skill to be tested. The systems and processes analyze the test taker's knowledge, skills, and cognitive function about the entire domain of the skill, rather than a single fact. The systems and processes provide security to test administration.

Abstract: Provided are multi-mode firearms, triggers, kits, and methods of use that allow a user to select between a semi-automatic firing mode and a pull-and-release firing mode that fires the firearm upon both pulling the trigger and releasing the trigger, by using the selector switch or other mechanism to change the amount the trigger can move. A safe mode that prevents the firearm from firing may also be selected in various example embodiments by using the selector switch or other mechanism to change the amount the trigger can move. In certain example embodiments the trigger cannot move at all in safe mode, can move more in semi-automatic mode, and can move yet more in pull-and-release mode. The modes can be positioned for selection in any order. Kits comprising a trigger assembly and a selector assembly are provided for retrofitting conventional semi-automatic firearms.

Abstract: The present invention relates to methods of treating female reproductive tract irritation (such as pain and pruritus) or/and inflammation.