Patents by Inventor David Francis Ackerley

David Francis Ackerley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of detecting and measuring glutamine and analogues thereof, and methods related thereto
    Patent number: 10725049
    Abstract: Method for the detection of glutamine and its analogues are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogues, including diagnostic methods. Further provided are methods that utilise glutamine analogues for the synthesis of coloured pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: July 28, 2020
    Assignee: VICTORIA LINK LIMITED
    Inventors: David Francis Ackerley, Alistair Sinclair Brown, Katherine Jane Robins
  • Antibacterial Compounds
    Publication number: 20190328687
    Abstract: The present invention relates to salicylamide compounds and compositions thereof effective in targeting growth of bacteria. The compounds and compositions of the present invention are particularly useful in, for example, the prevention or treatment of bacterial infection and the prevention, reduction or elimination of biofilm formation.
    Type: Application
    Filed: November 17, 2015
    Publication date: October 31, 2019
    Inventors: Janine Naomi Copp, David Francis Ackerley
  • ANTIBACTERIAL COMPOSITIONS
    Publication number: 20190274978
    Abstract: The present invention provides compositions, including pharmaceutical compositions, comprising a salicylamide compound and an agent that increases the permeability of a bacterial cell membrane for use in treating or preventing bacterial infections.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 12, 2019
    Inventors: David Francis Ackerley, Janine Naomi Copp
  • Bacterial nitroreductase enzymes and methods relating thereto
    Patent number: 10357577
    Abstract: The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: more particularly, although not exclusively, the enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: July 23, 2019
    Assignees: AUCKLAND UNISERVICES LIMITED, VICTORIA LINK LIMITED
    Inventors: Christopher Paul Guise, David Francis Ackerley, Amir Ashoorzadeh, Janine Naomi Copp, Jack Urquhart Flanagan, Alexandra Marie Mowday, Adam Vorn Patterson, Gareth Adrian Prosser, Jeffrey Bruce Smaill, Sophie Phillipa Syddall, Elsie May Williams
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20190153002
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 10202408
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: February 12, 2019
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • METHODS OF DETECTING AND MEASURING GLUTAMINE AND ANALOGUES THEREOF, AND METHODS RELATED THERETO
    Publication number: 20180246116
    Abstract: Method for the detection of glutamine and its analogues are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogues, including diagnostic methods. Further provided are methods that utilise glutamine analogues for the synthesis of coloured pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.
    Type: Application
    Filed: February 12, 2018
    Publication date: August 30, 2018
    Inventors: David Francis ACKERLEY, Alistair Sinclair BROWN, Katherine Jane ROBINS
  • Methods of detecting and measuring glutamine and analogues thereof, and methods related thereto
    Patent number: 9995750
    Abstract: Method for the detection of glutamine and its analogs are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogs, including diagnostic methods. Further provided are methods that utilize glutamine analogs for the synthesis of colored pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 12, 2018
    Assignee: Victoria Link Limited
    Inventors: David Francis Ackerley, Alistair Sinclair Brown, Katherine Jane Robins
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20180148463
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: January 22, 2018
    Publication date: May 31, 2018
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 9873710
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: January 23, 2018
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20170044191
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: October 31, 2016
    Publication date: February 16, 2017
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 9505791
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: November 29, 2016
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • METHODS OF DETECTING AND MEASURING GLUTAMINE AND ANALOGUES THEREOF, AND METHODS RELATED THERETO
    Publication number: 20160299151
    Abstract: Method for the detection of glutamine and its analogues are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogues, including diagnostic methods. Further provided are methods that utilise glutamine analogues for the synthesis of coloured pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.
    Type: Application
    Filed: December 5, 2014
    Publication date: October 13, 2016
    Inventors: David Francis ACKERLEY, Alistair Sinclair BROWN, Katherine Jane ROBINS
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20150299230
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: August 22, 2013
    Publication date: October 22, 2015
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Compounds And Methods For Selective Imaging And/Or Ablation
    Publication number: 20150010474
    Abstract: The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and are substantially insensitive to metabolism under oxic or hypoxic conditions by human nitroreductase enzymes.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 8, 2015
    Inventors: Robert Forbes Anderson, Jeffery Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, David Francis Ackerley, Janine Naomi Copp, Alexandra Marie Mowday, Elsie May Williams, Christopher Paul Guise, Cameron Koch, Alex Kachur, William R. Dolbier, JR.
  • BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO
    Publication number: 20130295011
    Abstract: The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: More particularly, although not exclusively, said enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 7, 2013
    Applicants: VICTORIA LINK LIMITED, AUCKLAND UNISERVICES LIMITED
    Inventors: Christopher Paul Guise, David Francis Ackerley, Amir Ashoorzadeh, Janine Naomi Copp, Jack Urquhart Flanagan, Alexandra Marie Mowday, Adam Vorn Patterson, Gareth Adrian Prosser, Jeffrey Bruce Smaill, Sophie Phillipa Syddall, Elsie May Williams