Patents by Inventor David Francis Tough

David Francis Tough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN PCAF FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES OR FOR THE TREATMENT OF CANCER
    Publication number: 20150203851
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions or cancer in a mammal, such as a human, which comprises the administration of an inhibitor of the bromodomain-containing protein PCAF.
    Type: Application
    Filed: September 4, 2013
    Publication date: July 23, 2015
    Inventors: Laurens Kruidenier, Kevin Lee, David Francis Tough, David Matthew Wilson
  • Inhibitors of SP140 and their use in therapy
    Patent number: 9018184
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of bromodomain-containing protein: SP140.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 28, 2015
    Assignee: Glaxo Group Limited
    Inventors: Kevin Lee, David Francis Tough
  • Method of treatment based on ATAD2 inhibitors
    Patent number: 8691747
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: April 8, 2014
    Assignee: Glaxo Group Limited
    Inventors: Laurens Kruidenier, Kevin Lee, David Francis Tough, David Matthew Wilson
  • Method of Treatment
    Publication number: 20140024558
    Abstract: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 23, 2014
    Applicant: Glaxo Group Limited
    Inventors: Kevin Lee, David Francis Tough, David Matthew Wilson
  • Inhibitors Of SP140 And Their Use In Therapy
    Publication number: 20130225661
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of bromodomain-containing protein: SP140.
    Type: Application
    Filed: November 23, 2011
    Publication date: August 29, 2013
    Inventors: Kevin Lee, David Francis Tough
  • Method of Treatment Based on ATAD2 Inhibitors
    Publication number: 20130224204
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
    Type: Application
    Filed: October 25, 2011
    Publication date: August 29, 2013
    Applicant: GLAXO GROUP LIMITED
    Inventors: Laurens Kruidenier, Kevin Lee, David Francis Tough, David Matthew Wilson
  • Method of Treatment
    Publication number: 20130210892
    Abstract: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: SP110
    Type: Application
    Filed: October 25, 2011
    Publication date: August 15, 2013
    Applicant: Glaxo Group Limited
    Inventors: Kevin Lee, David Francis Tough
  • Method Of Treatment
    Publication number: 20120202875
    Abstract: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.
    Type: Application
    Filed: October 26, 2010
    Publication date: August 9, 2012
    Inventors: Kevin Lee, David Francis Tough, David Matthew Wilson