Patents by Inventor David Frederik Fischer

David Frederik Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Identifying and Compounds Useful for Increasing the Functional Activity and Cell Surface Expression of CF-Associated Mutant Cystic Fibrosis Transmembrance Conductance Regulator
    Publication number: 20140256790
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Inventors: David Frederik Fischer, Richard Antonius Jozef Janssen, Marjet Roseboom, Amelia Katie Scaffidi, Michela Angela Tessari
  • Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator
    Patent number: 8765376
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: July 1, 2014
    Assignee: Galapagos NV
    Inventors: David Frederik Fischer, Richard Antonius Jozef Janssen, Marjet Roseboom, Amelia Katie Scaffidi, Michela Tessari
  • METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20110245322
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
    Type: Application
    Filed: September 10, 2009
    Publication date: October 6, 2011
    Inventors: David Frederik Fischer, Richard Antonius Jozef Janssen, Marjet Roseboom, Amelia Katie Scaffidi, Michela Tessari
  • MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20110077283
    Abstract: The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease.
    Type: Application
    Filed: February 3, 2009
    Publication date: March 31, 2011
    Inventors: David Frederik Fischer, Richard Antonius Jozef Janssen, Remko De Pril, Desiré Maria Petronella Catharina Van Steenhoven, Seung Kwak, David S. Howland, Ethan Signer