Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engagers each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: Beehives, beehive comb frames, and methods of for keeping honey bees are provided. The beehives include a housing; at least one enclosure in the housing having a top, a bottom, and sides; at least one elongated rod extending horizontally between two of the sides of the at least one enclosure; and a plurality of comb frames adapted to receive honeycomb, each of the plurality of comb frames having a mounting mechanism, for example, a hook, adapted to releasably engage the at least one elongated rod. The beehive comb frames include a top bar; two side pieces extending from opposing ends of the top bar; and at least one mounting mechanism, such as, a hook, attached to the top bar, the mounting mechanism adapted to releasably engage a hive enclosure. The beehives and comb frames are uniquely adapted to facilitate maintenance of the hives and the harvesting of honey.

Abstract: In an aspect, a vehicular door hinge is provided and includes a door-hinge component that is configured to mount to a vehicle door and a body-hinge component that is configured to mount to a vehicle body. The door hinge component is pivotally mounted to the body hinge component. A first one of the door- and body-hinge components is made from folded sheet metal and has a fold. Each of the door- and body-hinge components has a stop surface that is engageable with the stop surface on the other of the door- and body-hinge components to limit relative pivoting movement between the door- and body-hinge components. The stop surface on the first of the door- and body-hinge components is at the fold.

Abstract: In an aspect, a kit of parts is provided for a check arm keeper, which includes a keeper housing having a mounting bracket and a cartridge-mounting portion, and a plunger cartridge that includes a plunger cartridge housing mountable to the keeper housing, a plunger slidable in the plunger cartridge housing, and a plunger-biasing member positioned in the plunger cartridge housing to urge the plunger out from the plunger cartridge housing. The plunger has a first engagement member and the plunger cartridge housing has a second engagement member. The engagement members cooperate to retain the plunger in the plunger cartridge housing against a biasing force of the plunger-biasing member when the plunger cartridge is free from the keeper housing. Mounting of the plunger cartridge housing holds it in a selected position relative to the keeper housing and drives the plunger to a position in which the engagement members are spaced apart.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engager (BiTE™) each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager (BiTE™) comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: In an aspect, a kit of parts is provided for a check arm keeper, which includes a keeper housing having a mounting bracket and a cartridge-mounting portion, and a plunger cartridge that includes a plunger cartridge housing mountable to the keeper housing, a plunger slidable in the plunger cartridge housing, and a plunger-biasing member positioned in the plunger cartridge housing to urge the plunger out from the plunger cartridge housing. The plunger has a first engagement member and the plunger cartridge housing has a second engagement member. The engagement members cooperate to retain the plunger in the plunger cartridge housing against a biasing force of the plunger-biasing member when the plunger cartridge is free from the keeper housing. Mounting of the plunger cartridge housing holds it in a selected position relative to the keeper housing and drives the plunger to a position in which the engagement members are spaced apart.

Abstract: Video transaction machines (VTMs) facilitate communications and transactions between customers of a financial institution and video transaction resources, such as video agents, by establishing a video session between a VTM and a video agent workstation. After a computing device of the financial institution receives information identifying the customer, VTM, or VTM location requesting the services of a video agent, the computing device may place the customer in one or more virtual queues based on an overall visit time at the VTM location. In order to maintain a visit time at the VTM location below a predetermined visit time threshold, the controller may prioritize transactions at VTMs with longer visit times over transactions at VTMs with shorter visit times.

Abstract: Aspects of the present disclosure are directed towards a transaction machine. The transaction machine may include a first transaction access point configured to provide a first set of transaction options and a second transaction access point configured to provide a second set of transaction options. An item cartridge may be shared between the first transaction access point and the second transaction access point. During a transaction, a routing mechanism may route an item from the item cartridge to an item dispenser of the first transaction access point or to an item dispenser of the second transaction access point.

Abstract: Video transaction machines (VTMs) facilitate communications and transactions between customers of a financial institution and video transaction resources, such as video agents, by establishing a video session between a VTM and a video agent workstation. After a computing device of the financial institution receives information identifying the customer, VTM, or VTM location requesting the services of a video agent, the computing device may place the customer in one or more virtual queues based on an overall visit time at the VTM location. In order to maintain a visit time at the VTM location below a predetermined visit time threshold, the controller may prioritize transactions at VTMs with longer visit times over transactions at VTMs with shorter visit times.

Abstract: Video transaction machines (VTMs) facilitate communications and transactions between customers of a financial institution and video transaction resources, such as video agents, by establishing a video session between a VTM and a video agent workstation. After a computing device of the financial institution receives information identifying the customer, VTM, or VTM location requesting the services of a video agent, the computing device may place the customer in one or more virtual queues based on an overall visit time at the VTM location. In order to maintain a visit time at the VTM location below a predetermined visit time threshold, the controller may prioritize transactions at VTMs with longer visit times over transactions at VTMs with shorter visit times.

Abstract: Systems, methods and apparatuses for authenticating a user via a machine-readable code arranged on a reusable payment device and a computing device are provided. An image of the machine-readable code may be received from a computing device, such as a mobile device. If it is determined that a match exists between a user associated with the mobile device and a user associated with the machine-readable code and/or reusable payment device, a user may be authenticated and may be provided with account information and/or account functionality. In some examples, the authentication may be used to pre-populate payment information during a transaction.

Abstract: Systems, methods, computer-readable media and apparatuses pre-processing a negotiable instrument, such as a check, are presented. An image of a portion of the check may be received, such as from a mobile device of a user. The portion provided in the image may include a convenience area of the check identifying an amount of the check as a numerical value and a quick response (QR) code. The QR code may contain data such as that contained in the magnetic ink character recognition (MICR) line of the check. The image may be processed to identify one or more options available for continued processing of the check or for cancelling the transaction. The options may be provided to the user, such as via a user interface. In some examples, the user interface may be provided on the mobile device used to capture the image of the portion of the check.

Abstract: Methods, systems, computer-readable media, and apparatuses for receiving and processing location information requests are presented. In some embodiments, a decision engine may aggregate location service information and transaction center status information. The location service information may identify one or more services that are available at each of a plurality of enterprise locations, and the transaction center status information may identify a current status of one or more transaction centers at each of the plurality of enterprise locations. Subsequently, the decision engine may receive, from a user device, a data request for a location to perform a defined service, and the data request may include location information for the user device at the time of the data request. In response to receiving the data request, the decision engine may provide one or more options to the user device based on the location service information and the transaction center status information.

Abstract: Aspects of the present disclosure are directed towards a transaction machine. The transaction machine may include a first transaction access point configured to provide a first set of transaction options and a second transaction access point configured to provide a second set of transaction options. An item cartridge may be shared between the first transaction access point and the second transaction access point. During a transaction, a routing mechanism may route an item from the item cartridge to an item dispenser of the first transaction access point or to an item dispenser of the second transaction access point.