Patents by Inventor David Fruman

David Fruman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MTOR modulators and uses thereof
    Patent number: 9629843
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: April 25, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, INTELLIKINE, INC.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • MTOR MODULATORS AND USES THEREOF
    Publication number: 20160000789
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: June 5, 2015
    Publication date: January 7, 2016
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • MTOR Modulators and Uses Thereof
    Publication number: 20110224223
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: July 8, 2009
    Publication date: September 15, 2011
    Applicants: The Regents of the University of California, a California corporation, Intellikine, Inc.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • Modulators of p85 expression
    Publication number: 20040028683
    Abstract: Methods of treating a subject having an insulin-related disorder, e.g., diabetes. The methods include reducing the amount of p85 PI3K regulatory subunit isoform in a cell of the subject.
    Type: Application
    Filed: June 2, 2003
    Publication date: February 12, 2004
    Applicants: Joslin Diabetes Center, Inc., a Massachusetts corporation, Beth Israel Deaconess Medical Center, Inc., a Massachusetts corporation
    Inventors: C. Ronald Kahn, Kohjirro Ueki, Frank Mauvais-Jarvis, David Fruman, Lewis Cantley
  • Modulators of p85 expression
    Publication number: 20020051786
    Abstract: Methods of treating a subject having an insulin-related disorder, e.g., diabetes. The methods include reducing the amount of p85 P13K regulatory subunit isoform in a cell of the subject.
    Type: Application
    Filed: June 22, 2001
    Publication date: May 2, 2002
    Inventors: C. Ronald Kahn, Kohjirro Ueki, Frank Mauvais-Jarvis, David Fruman, Lewis Cantley