Patents by Inventor David G Amaral

David G Amaral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSTIC METHODS FOR THE DETECTION OF RISK OF NEURODEVELOPMENTAL DISORDERS
    Publication number: 20120115166
    Abstract: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.
    Type: Application
    Filed: October 18, 2011
    Publication date: May 10, 2012
    Applicant: The Regents of the University of California
    Inventors: David G. Amaral, Judy Van de Water
  • Diagnostic methods for the detection of risk of autistic spectrum disorder
    Patent number: 8043820
    Abstract: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: October 25, 2011
    Assignee: The Regents of the University of California
    Inventors: David G. Amaral, Judy Van de Water
  • Biomarkers for diagnosing an autism spectrum disorder
    Patent number: 7604948
    Abstract: The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using cytometry and mass spectrometry. The invention further provides methods of using the identified biomarkers to diagnose the presence of a neurodevelopmental disorder, including an autism spectrum disorder.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: October 20, 2009
    Assignee: The Regents of the University of California
    Inventors: David G. Amaral, Blythe A. Corbett
  • DIAGNOSTIC METHODS FOR THE DETECTION OF RISK OF NEURODEVELOPMENTAL DISORDERS
    Publication number: 20090074667
    Abstract: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.
    Type: Application
    Filed: November 7, 2008
    Publication date: March 19, 2009
    Applicant: The Regents of the University of California
    Inventors: David G. Amaral, Judy Van de Water
  • Diagnostic methods for the detection of autism spectrum disorder
    Patent number: 7452681
    Abstract: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: November 18, 2008
    Assignee: The Regents of the University of California
    Inventors: David G Amaral, Judy Van de Water
  • Method for reducing neuronal degeneration associated with seizure
    Patent number: 5786187
    Abstract: The invention provides a method for regulating neuronal degeneration resulting from injury to nervous tissue. The method includes regulating the expression or activity of protease, preferably tissue-type plasminogen activator (tPA), by microglial cells. Alternatively, the method involves regulating microglial activation in response to injurious conditions. The method, in an alternative embodiment, includes detecting tPA expression or activity, or detecting microglial activation. In addition, the method includes assessing the susceptibility of a human or animal subject to seizure, and may involve detecting the activity or expression of tPA, and may further involve comparing a measured level of tPA expression or activity with a reference level associated with a given probability of seizure.
    Type: Grant
    Filed: September 21, 1995
    Date of Patent: July 28, 1998
    Assignee: The Research Foundation of State University of New York
    Inventors: Sidney Strickland, Styliani-Anna Tsirka, David G. Amaral