Patents by Inventor David G. Grier

David G. Grier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200319086
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 8, 2020
    Applicant: NEW YORK UNIVERSITY
    Inventors: David G. GRIER, Fook Chiong CHEONG, Ke XIAO
  • Patent number: 10656065
    Abstract: Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: May 19, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, David B. Ruffner, Aaron Yevick, Mark Hannel
  • Patent number: 10641696
    Abstract: Impurities within a sample are detected by use of holographic video microscopy. The sample flows through the microscope and holographic images are generated. The holographic image is analyzed to identify regions associated with large impurities in the sample. The contribution of the particles of the sample to the holographic images is determined and the impurities are characterized.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: May 5, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: David B. Ruffner, David G. Grier, Laura Philips
  • Patent number: 10634604
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 28, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, Fook Chiong Cheong, Ke Xiao
  • Patent number: 10222315
    Abstract: Holograms of colloidal dispersions encode comprehensive information about individual particles' three-dimensional positions, sizes and optical properties. Extracting that information typically is computation-ally intensive, and thus slow. Machine-learning techniques based on support vector machines (SVMs) can analyze holographic video microscopy data in real time on low-power computers. The resulting stream of precise particle-resolved tracking and characterization data provides unparalleled insights into the composition and dynamics of colloidal dispersions and enables applications ranging from basic research to process control and quality assurance.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: March 5, 2019
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, Aaron Yevick, Mark Hannel
  • Patent number: 10119900
    Abstract: Holographic video microscopy yields fast and accurate measurements of the size and refractive index of individual colloidal particles. Particle-resolved characterization offers useful insights into the progress of colloidal synthesis without relying on models for the distributions of particle sizes and properties, and can be performed rapidly enough to provide feedback for process control. The measured increase in the most probable radius over the course of the reaction is consistent with the LaMer model for colloidal growth. Uniformity in the measured refractive index suggests that the spheres grow with uniform density. The joint distribution of size and refractive index provides evidence for a low rate of nucleation proceeding after the initial nucleation event. The same analysis reveals that these PDMS particles shrink by compactification in the first few days after their synthesis.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 6, 2018
    Assignee: NEW YORK UNIVERSITY
    Inventors: Chen Wang, Hagay Shpaisman, Andrew Hollingsworth, David G. Grier
  • Publication number: 20180252628
    Abstract: Impurities within a sample are detected by use of holographic video microscopy. The sample flows through the microscope and holographic images are generated. The holographic image is analyzed to identify regions associated with large impurities in the sample. The contribution of the particles of the sample to the holographic images is determined and the impurities are characterized.
    Type: Application
    Filed: September 15, 2016
    Publication date: September 6, 2018
    Inventors: David B. RUFFNER, David G. GRIER, Laura PHILIPS
  • Patent number: 9989451
    Abstract: A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: June 5, 2018
    Assignee: NEW YORK UNIVERSITY
    Inventors: Fook Chiong Cheong, Ke Xiao, David Pine, David G. Grier
  • Publication number: 20180011001
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 11, 2018
    Inventors: David G. GRIER, Fook Chiong CHEONG, Ke XIAO
  • Patent number: 9810894
    Abstract: In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the particles' sizes with nanometer resolution, their refractive indexes to within one part in a thousand, and their three dimensional positions with nanometer resolution. This procedure can rapidly and directly characterize mechanical, optical and chemical properties of the specimen and its medium.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 7, 2017
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, Sang-Hyuk Lee, Fook C. Cheong
  • Publication number: 20170307497
    Abstract: Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.
    Type: Application
    Filed: November 11, 2015
    Publication date: October 26, 2017
    Inventors: David G. GRIER, David B. RUFFNER, Aaron YEVICK, Mark HANNEL
  • Publication number: 20170241891
    Abstract: Holograms of colloidal dispersions encode comprehensive information about individual particles' three-dimensional positions, sizes and optical properties. Extracting that information typically is computation-ally intensive, and thus slow. Machine-learning techniques based on support vector machines (SVMs) can analyze holographic video microscopy data in real time on low-power computers. The resulting stream of precise particle-resolved tracking and characterization data provides unparalleled insights into the composition and dynamics of colloidal dispersions and enables applications ranging from basic research to process control and quality assurance.
    Type: Application
    Filed: October 12, 2015
    Publication date: August 24, 2017
    Inventors: David G. GRIER, Aaron YEVICK, Mark HANNEL
  • Patent number: 9719911
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: August 1, 2017
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, Fook Chiong Cheong, Ke Xiao
  • Publication number: 20170191920
    Abstract: A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
    Type: Application
    Filed: December 12, 2016
    Publication date: July 6, 2017
    Applicant: National Science Foundation
    Inventors: Fook Chiong Cheong, Ke Xiao, David Pine, David G. Grier
  • Publication number: 20170184485
    Abstract: Holographic video microscopy yields fast and accurate measurements of the size and refractive index of individual colloidal particles. Particle-resolved characterization offers useful insights into the progress of colloidal synthesis without relying on models for the distributions of particle sizes and properties, and can be performed rapidly enough to provide feedback for process control. The measured increase in the most probable radius over the course of the reaction is consistent with the LaMer model for colloidal growth. Uniformity in the measured refractive index suggests that the spheres grow with uniform density. The joint distribution of size and refractive index provides evidence for a low rate of nucleation proceeding after the initial nucleation event. The same analysis reveals that these PDMS particles shrink by compactification in the first few days after their synthesis.
    Type: Application
    Filed: June 24, 2015
    Publication date: June 29, 2017
    Applicant: New York University
    Inventors: Chen WANG, Hagay SHPAISMAN, Andrew HOLLINGSWORTH, David G. GRIER
  • Publication number: 20170059468
    Abstract: A method and system for identification of holographic tracking and identification of features of an object. A holograph is created from scattering off the object, intensity gradients are established for a plurality of pixels in the holograms, the direction of the intensity gradient is determined and those directions analyzed to identify features of the object and enables tracking of the object. Machine learning devices can be trained to estimate particle properties from holographic information.
    Type: Application
    Filed: February 12, 2015
    Publication date: March 2, 2017
    Applicant: New York University
    Inventors: Aaron Yevick, Mark Hannel, David G. Grier, Bhaskar Jyoti Krishnatreya
  • Patent number: 9519129
    Abstract: A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: December 13, 2016
    Assignee: New York University
    Inventors: Fook Chiong Cheong, Ke Xiao, David Pine, David G. Grier
  • Publication number: 20160216195
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Application
    Filed: April 4, 2016
    Publication date: July 28, 2016
    Applicant: New York University
    Inventors: David G. GRIER, Fook Chiong CHEONG, Ke XIAO
  • Patent number: 9316578
    Abstract: An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: April 19, 2016
    Assignee: New York University
    Inventors: David G. Grier, Fook Chiong Cheong, Ke Xiao
  • Patent number: 9188529
    Abstract: An in-line holographic microscope is used for measurements of micrometer-scale particles and associated suspending fluid medium containing the particles. The system yields heterodyne scattering patterns that may be interpreted with Lorenz-Mie theory to obtain precise time-resolved information on the refractive index of the suspending medium for determining chemical composition, concentrations and makeup thereof. This approach can perform spatially resolved refractometry with measurements on calibrated refractive index standards and monitor chemical concentration in a microfluidic channel. Using commercially available colloidal spheres as probe particles and a standard video camera for detection yields volumetric refractive index measurements with a resolution of 2×10?3 RIU for each probe particle in each holographic snapshot.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: November 17, 2015
    Assignee: NEW YORK UNIVERSITY
    Inventors: Hagay Shpaisman, Bhaskar Jyoti Krishnatreya, David G. Grier