Patents by Inventor David G. Lowe
David G. Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7435413Abstract: The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.Type: GrantFiled: December 23, 2003Date of Patent: October 14, 2008Assignee: Genentech, Inc.Inventors: Daniel K. Kirchhofer, David G. Lowe, Leonard G. Presta
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Patent number: 6875567Abstract: The present invention is based upon the identification of genes which are differentially expressed in hypertrophic cardiac tissue as compared to normal cardiac tissue. Accordingly, the present invention provides nucleotide sequences of genes selected from the group consisting of CH-1, CH-2, CH-3, CH-4, CH-5, CH-6, CH-7, CH-8, and CH-9, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. The invention also provides therapeutic methods and pharmaceutical compositions which are based on the promotion or inhibition of the function of the differentially expressed genes. The invention further provides methods of diagnosis, prognosis and screening for a disposition for diseases or disorders associated with cardiac hypertrophy. Methods for screening for modulators of the protein products of the differentially expressed genes in cardiac hypertrophy tissue are additionally provided.Type: GrantFiled: November 10, 1998Date of Patent: April 5, 2005Assignees: Genentech, Inc., Curagen CorporationInventors: Richard A. Shimkets, David G. Lowe
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Publication number: 20040157246Abstract: The present invention is based upon the identification of genes which are differentially expressed in hypertrophic cardiac tissue as compared to normal cardiac tissue. Accordingly, the present invention provides nucleotide sequences of genes selected from the group consisting of CH-1, CH-2, CH-3, CH-4, CH-5, CH-6, CH-7, CH-8, and CH-9 and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. The invention also provides therapeutic methods and pharmaceutical compositions which are based on the promotion or inhibition of the function of the differentially expressed genes. The invention further provides methods of diagnosis, prognosis and screening for a disposition for diseases or disorders associated with cardiac hypertrophy. Methods for screening for modulators of the protein products of the differentially expressed genes in cardiac hypertrophy tissue are additionally provided.Type: ApplicationFiled: November 25, 2003Publication date: August 12, 2004Inventors: Richard A. Shimkets, David G. Lowe
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Publication number: 20040126816Abstract: The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.Type: ApplicationFiled: December 23, 2003Publication date: July 1, 2004Applicant: GENENTECH, INC.Inventors: Daniel K. Kirchhofer, David G. Lowe, Leonard G. Presta
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Patent number: 6711293Abstract: A method and apparatus for identifying scale invariant features in an image and a further method and apparatus for using such scale invariant features to locate an object in an image are disclosed. The method and apparatus for identifying scale invariant features may involve the use of a processor circuit for producing a plurality of component subregion descriptors for each subregion of a pixel region about pixel amplitude extrema in a plurality of difference images produced from the image. This may involve producing a plurality of difference images by blurring an initial image to produce a blurred image and by subtracting the blurred image from the initial image to produce the difference image. For each difference image, pixel amplitude extrema are located and a corresponding pixel region is defined about each pixel amplitude extremum. Each pixel region is divided into subregions and a plurality of component subregion descriptors are produced for each subregion.Type: GrantFiled: March 6, 2000Date of Patent: March 23, 2004Assignee: The University of British ColumbiaInventor: David G. Lowe
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Patent number: 6703494Abstract: The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.Type: GrantFiled: March 8, 2001Date of Patent: March 9, 2004Assignee: Genentech, Inc.Inventors: Daniel K. Kirchhofer, David G. Lowe, Leonard G. Presta
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Publication number: 20030190660Abstract: Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.Type: ApplicationFiled: April 2, 2003Publication date: October 9, 2003Applicant: Genentech, Inc.Inventors: David G. Lowe, James C. Marsters, Edward P. Robbie, Victoria Smith
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Patent number: 6610480Abstract: The present invention is based upon the identification of genes which are differentially expressed in hypertrophic cardiac tissue as compared to normal cardiac tissue. Accordingly, the present invention provides nucleotide sequences of genes selected from the group consisting of CH-1, CH-2, CH-3, CH-4, CH-5, CH-6, CH-7, CH-8, and CH-9, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. The invention also provides therapeutic methods and pharmaceutical compositions which are based on the promotion or inhibition of the function of the differentially expressed genes. The invention further provides methods of diagnosis, prognosis and screening for a disposition for diseases or disorders associated with cardiac hypertrophy. Methods for screening for modulators of the protein products of the differentially expressed genes in cardiac hypertrophy tissue are additionally provided.Type: GrantFiled: November 9, 1998Date of Patent: August 26, 2003Assignees: Genentech, Inc., Curagen CorporationInventors: Richard A. Shimkets, David G. Lowe
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Publication number: 20030119075Abstract: The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.Type: ApplicationFiled: March 8, 2001Publication date: June 26, 2003Applicant: GENENTECH, INC.Inventors: Daniel K. Kirchhofer, David G. Lowe, Leonard G. Presta
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Patent number: 6525022Abstract: Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.Type: GrantFiled: September 16, 1998Date of Patent: February 25, 2003Assignee: Genentech, Inc.Inventors: David G. Lowe, Brian C. Cunningham, David Oare, Robert S. McDowell, John P. Burnier
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Publication number: 20020081597Abstract: Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.Type: ApplicationFiled: March 30, 2001Publication date: June 27, 2002Applicant: GENENTECH, INC.Inventors: David G. Lowe, James C. Marsters, Edward P. Robbie, Victoria Smith
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Patent number: 6028055Abstract: Compounds related to BNP have reduced binding affinity for the natriuretic peptide receptor-C but possess improved or equivalent affinity to the wild type BNP for natriuretic peptide receptor-A. The BNP related compounds are suitable for use in the treatment or prophylaxis of various pathological conditions associated with water or electrolyte imbalance.Type: GrantFiled: October 21, 1997Date of Patent: February 22, 2000Assignee: Genetech, Inc.Inventors: David G. Lowe, Jill R. Schoenfeld
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Patent number: 5846932Abstract: Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.Type: GrantFiled: June 6, 1995Date of Patent: December 8, 1998Assignee: Genentech, Inc.Inventors: David G. Lowe, Brian C. Cunningham, David Oare, Robert S. McDowell, John P. Burnier
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Patent number: 5352587Abstract: Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.Type: GrantFiled: December 19, 1991Date of Patent: October 4, 1994Assignee: Genentech, Inc.Inventors: Ming-Shi Chang, David V. Goeddel, David G. Lowe