Patents by Inventor David G. McLone

David G. McLone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods of Detecting and Treating Neural Tube Defects
    Publication number: 20150025008
    Abstract: The present invention generally relates to compositions, reagents and methods for detecting and treating a neural tube defect in a fetus. One aspect of the invention provides a method including administrating a composition containing noggin or LDN-193189 to the fetus in utero. In certain embodiments, the composition is administrated if the maternal blood or amniotic fluid contains an elevated amount of BMP4 and/or a reduced amount of noggin. In another aspect of the invention, the method includes administrating a composition containing GDC-0449 to the fetus in utero. In certain embodiments, the GDC-0449 is administrated if the maternal blood or amniotic fluid contains an elevated amount of sonic hedgehog.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 22, 2015
    Inventors: Chandra Shekhar Mayanil, Elise Allender, Takao Tsurubuchi, Norman Ginsberg, David G. McLone, Tadanori Tomita