Patents by Inventor David G. Ousterout

David G. Ousterout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALTERING THE NORMAL BALANCE OF MICROBIAL POPULATIONS
    Publication number: 20240067935
    Abstract: Disclosed herein are compositions comprising exogenous antimicrobial agents and methods of use.
    Type: Application
    Filed: December 22, 2021
    Publication date: February 29, 2024
    Inventors: David G. OUSTEROUT, Kurt SELLE, Cameron PRYBOL
  • PHAGE COMPOSITIONS FOR PSEUDOMONAS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20240011041
    Abstract: Disclosed here are phage compositions targeting a Pseudomonas species comprising CRISPR-Cas systems and methods of use thereof.
    Type: Application
    Filed: November 4, 2021
    Publication date: January 11, 2024
    Inventors: Paul GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Hannah Hewitt TUSON, Lana MCMILLAN, Robert MCKEE, Taylor PENKE, Shaun STEELE, Christopher LADNER, Gabriel AL-GHALITH
  • PHAGE COMPOSITIONS FOR ESCHERICHIA COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20230398161
    Abstract: Disclosed here are phage compositions for Escherichia comprising CRISPR-Cas systems and methods of use thereof.
    Type: Application
    Filed: November 4, 2021
    Publication date: December 14, 2023
    Inventors: Paul GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Hannah Hewitt TUSON, Lana MCMILLAN, Drew DELORENZO, Robert MCKEE, Cameron PRYBOL
  • PHAGE DELIVERY OF ANTI-INFLAMMATORY PEPTIDES
    Publication number: 20230346861
    Abstract: Disclosed herein are bacteriophage comprising an therapeutic peptide and methods for the use thereof.
    Type: Application
    Filed: May 4, 2022
    Publication date: November 2, 2023
    Inventors: David G. OUSTEROUT, Kurt SELLE, Shaun STEELE
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20230038106
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: September 16, 2022
    Publication date: February 9, 2023
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • PHAGE COMPOSITIONS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20220411782
    Abstract: Disclosed here are phage compositions comprising Type I CRISPR-Cas systems and methods of use thereof. In some embodiments, disclosed herein is a nucleic acid sequence comprising (a) a first CRISPR array designed to be operable with a first Type I CRISPR-Cas system, and (b) a second CRISPR array designed to be operable with a second Type I CRISPR-Cas system, wherein the first Type I CRISPR-Cas system and the second Type I CRISPR-Cas system are different Type I CRISPR-Cas systems.
    Type: Application
    Filed: November 5, 2020
    Publication date: December 29, 2022
    Inventors: David G. OUSTEROUT, Kurt SELLE
  • CRISPR CAS SYSTEMS AND LYSOGENY MODULES
    Publication number: 20220389392
    Abstract: Disclosed herein are compositions and methods for modifying a bacterial population. In some embodiments, described herein is a bacteriophage comprising a first nucleic acid sequence encoding a first spacer sequence or a crRNA transcribed therefrom, wherein the first spacer sequence is complementary to a target nucleotide sequence from a target gene in a target bacterium, provided that the bacteriophage is rendered lytic.
    Type: Application
    Filed: November 5, 2020
    Publication date: December 8, 2022
    Inventors: David G. OUSTEROUT, Paul M. GAROFOLO, Kurt SELLE, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220387531
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: July 6, 2022
    Publication date: December 8, 2022
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220380736
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: July 6, 2022
    Publication date: December 1, 2022
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • PHAGE COMPOSITIONS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20220370526
    Abstract: Disclosed here are phage compositions comprising CRISPR-Cas systems and methods of use thereof. In certain embodiments, disclosed herein is a bacteriophage comprising a nucleic acid sequence encoding a Type I CRISPR-Cas system comprising: (a) a CRISPR array; (b) a Cascade polypeptide; and (c) a Cas3 polypeptide. In some embodiments, the CRISPR array comprises a spacer sequence and at least one repeat sequence. In some embodiments, the at least one repeat sequence is operably linked to the spacer sequence at either its 5? end or its 3? end.
    Type: Application
    Filed: November 5, 2020
    Publication date: November 24, 2022
    Inventors: David G. OUSTEROUT, Paul M. GAROFOLO, Kurt SELLE, Hannah Hewitt TUSON
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20220002681
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: September 8, 2021
    Publication date: January 6, 2022
    Inventors: Paul M. GAROFOLO, David G. Ousterout, Kurt Selle, Sandi Wong, Hannah Hewitt Tuson
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20210161150
    Abstract: Provided herein are methods and compositions for killing a target bacterium with a CRISPR-Cpf1 system. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: May 24, 2019
    Publication date: June 3, 2021
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Chase Lawrence BEISEL, Atul Kumar SINGH
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20210032654
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: July 13, 2020
    Publication date: February 4, 2021
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20210002665
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: April 26, 2020
    Publication date: January 7, 2021
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
    Publication number: 20200354690
    Abstract: Provided herein are methods and compositions for killing a target bacterium. Also disclosed are engineered bacteriophages.
    Type: Application
    Filed: June 11, 2020
    Publication date: November 12, 2020
    Inventors: Paul M. GAROFOLO, David G. OUSTEROUT, Kurt SELLE, Sandi WONG, Hannah Hewitt TUSON
  • RNA-guided gene editing and gene regulation
    Patent number: 10745714
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: August 18, 2020
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-guided gene editing and gene regulation
    Patent number: 10704060
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 7, 2020
    Assignee: Duke University
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20180320197
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: May 29, 2018
    Publication date: November 8, 2018
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black
  • RNA-GUIDED GENE EDITING AND GENE REGULATION
    Publication number: 20160201089
    Abstract: Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.
    Type: Application
    Filed: June 5, 2014
    Publication date: July 14, 2016
    Inventors: Charles A. Gersbach, Isaac B. Hilton, Pablo Perez-Pinera, Ami M. Kabadi, Pratiksha I. Thakore, David G. Ousterout, Joshua B. Black