Abstract: Novel CompoundsA compound of formula (I): ##STR1## where the substituents are defined later in the specification. The compounds are useful as muscle relaxants and as such have a number of pharmaceutical uses.

Abstract: A method and apparatus measure squareness of an end of a rod relative to a longitudinal centerline axis thereof without requiring rotation of the rod. The apparatus includes a flat plate mounted substantially perpendicularly to the rod centerline axis. The method positions the plate in abutting contact with the rod end, and a tilt angle of the plate in abutting contact with the rod end is measured for determining squareness of the rod end.

Abstract: A releasable clamp for the interior of an elongated tube, for use in telescopic tube arrangements and the like. The clamp comprises an outwardly expandable split ring having open ends and sides of cylindrical configuration, the sides of the split ring expanding outwardly to frictionally engage the interior surfaces of the tube when in expanded position, the split ring slidably movable longitudinally within the tube when the sides of the split ring are in unexpanded position. Wedges are provided, co-operating with the open ends of the split ring to bear against the ends of the split ring to force the sides of the split ring outwardly to expand it, tube engaging position. This releasable clamp may be used, for example, in an adjustable length handle for an appliance such as a floor polisher.

Abstract: A compound of formula (IA) in the form of a pharmaceutically acceptable microfine powder is disclosed.

Abstract: To inspect the integrity of pressurization holes in nuclear fuel rod final end plugs, quality assurance apparatus includes an adapter providing a test chamber into which an end plug is inserted. Instrument gas is introduced into the test chamber through an inlet port for flow to the atmosphere through the pressurization hole. A mass flow meter measures the gas flow through the pressurization hole to determine if it is capable of supporting requisite pressurization of a nuclear fuel rod when the end plug is assembled thereto.

Abstract: To provide quality assurance inspection of the dimensional characteristics of cells to be incorporated in spacers utilized in nuclear fuel bundles to establish critical spacings between fuel rods, a cell is placed in a fixture dimensioned to gauge the outer dimensions of the cell. A fuel rod-simulating pin is then inserted through the cell to rest on fuel rod-positioning stops formed on the cell. "Go, no go" feeler gauges then check the dimensions of the gaps between the fixture and pin.

Abstract: A compound of the general formula (I): ##STR1## or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof, wherein,R.sup.o represents a substituted or unsubstituted aryl group or a substituted or unsubstituted benzofuranyl group,X represents a bond or --O--CH.sub.2 --,R.sup.1 represents a hydrogen atom or a moiety ##STR2## wherein R.sup.o and X are as defined above; R.sup.2 and R.sup.3 independently represent a hydrogen atom or an alkyl group,n represents an integer 1 or 2,Y represents a bond or a moiety --CH.sub.2 --O--, moiety A represents an aryl group,R.sup.4 represents a linking group, andR.sup.5 represents a substituted or unsubstituted, monocyclic or fused ring heterocyclic group, having up to four heteroatoms in each ring selected from, oxygen, nitrogen and sulphur; provided that R.sup.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein a and b together form an --O-- or --CH.sub.2 -- linkage or a bond;either Y is N and R.sub.2 is hydrogen; orY is C-R.sub.1whereineither one of R.sub.1 and R.sub.2 is hydrogen and the other is nitro, cyano, halo, CF.sub.3, formyl, aldoxime, CF.sub.3 O, NO.sub.2 --CH.dbd.CH--, NC--CH.dbd.CH--; a group R.sub.x X-- wherein R.sub.x and C.sub.1-6 alkyl, aryl or heteroaryl either of which may be optionally substituted by one, two or three of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, halo, CF.sub.3 and cyano; and X is C.dbd.O, O.C.dbd.O, C.dbd.0.0, CHOH, SO, SO.sub.2, 0.SO, 0.SO.sub.2, CONH, 0.CONH, C.dbd.S, 0.C.dbd.S, C.dbd.S.0, CH.SH, SONH, SO.sub.2 NH, 0.SONH, 0.SO.sub.2 NH, CO--CH.dbd.CH, C.dbd.NHOH, C.dbd.NNH.sub.2 ; or a group R.sub.y R.sub.z NZ-- wherein R.sub.y and R.sub.z are independently hydrogen or C.sub.1-6 alkyl and Z is C.dbd.O, SO or SO.sub.2 ; orR.sub.1 is a C.sub.3-8 cycloalkyl group or a C.sub.

Abstract: An improved fastener assembly (10) for securing a rocker arm cover (11) to an engine block (13) is described. In the preferred embodiment, the fastener assembly is comprised of a bolt (15) with an unthreaded shaft (15b) between a head (15a) and a threaded end (15c) along a longitudinal axis of the bolt. The bolt is in a slideable relationship within a cylindrical opening (19a) through a grommet (19) and a secured washer (17). Projections or interference portions (15e) on the unthreaded shaft adjacent to the threaded section and opposite the head, restrict the axial movement of the bolt within the grommet and the washer. While the rocker arm cover is being alilgned on the engine block, the bolt is in an up position with the projecting surfaces adjacent to the washer. Once the rocker arm cover is aligned, the bolt is threadingly mated with a threaded aperture (13a) in the engine block.

Abstract: The compounds of the formula (II): ##STR1## and their pharmaceutically acceptable salts wherein R.sub.1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R.sub.3 is a hydrogen or chlorine atom or a hydroxyl group; R.sub.4 is a carboxylic acid group or a salt, ester or amide thereof; R.sub.5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R.sub.6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or anti-hyperglycaemic activity.

Abstract: A combined wind direction indicator and rain gauge is described in which the rain gauge is mounted on a vertically suspended sail at one end of a horizontally disposed elongated member which rotates in a horizontal circle in response to the force of inpinging wind. The rain gauge is so disposed that it is always maintained with its open mouth pointed into the direction of wind and at an angle of such that it coincides with the inclination of disending rainfall. Accuracy in measuring rainfall over a given period of time is thereby enhanced since the amount of rainfall collected will not be influenced by the angle of decent thereof. The device is further characterized by having a weighted head at the end of the elongated member remote from the rain gauge to counter balance the weight of the rain gauge and the sail on which it is mounted.

Abstract: The compounds of the formula (II): ##STR1## and their pharmaceutically acceptable salts wherein R.sub.1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R.sub.3 is a hydrogen or chlorine atom or a hydroxyl group; R.sub.4 is a carboxylic acid group or a salt, ester or amide thereof; R.sub.5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R.sub.6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or anti-hyperglycaemic activity.

Abstract: Ice hockey practice equipment for improving puck handling skills including a puck-like member having a groove in an upper surface thereof for receiving a hockey stick blade, and a locating member for maintaining the blade in location within the groove with lost motion between the puck-like member and the blade, the equipment thereby permitting constant interaction and feel of the puck-like member and the blade for a trainee.

Abstract: The compounds of the formula (II): ##STR1## and their pharmaceutically acceptable salts wherein R.sub.1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R.sub.3 is a hydrogen or chlorine atom or a hydroxyl group; R.sub.4 is a carboxylic acid group or a salt, ester or amide thereof; R.sub.5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R.sub.6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or antihyperglycaemic activity.

Abstract: Compounds having the formula: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Y and X are as defined hereinbelow, are useful for the reduction of abnormally high blood glucose and lipid levels in the treatment of obesity or hyperglycaemia.

Abstract: Compounds of formula (II): ##STR1## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, wherein R.sup.1 and R.sup.2, which may be the same or different, are each of a hydrogen atom or a methyl group, n is 1, 2 or 3, and Z is a C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, or a halogen or hydrogen atom are useful in treating obesity and/or hyperglycaemia and/or inflammation in mammals.

Abstract: The compounds of formula (II): ##STR1## in which R.sub.1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R.sub.3 is a hydrogen, chlorine or bromine atom or a hydroxyl group, R.sub.4 is a hydrogen atom or a methyl group; R.sub.5 is a hydrogen atom or a methyl group; R.sub.6 is a hydrogen, fluorine or chlorine atom or a methyl, methoxyl or hydroxy group; X is an oxygen atom or a bond; Y is an alkylene group of up to 6 carbon atoms or a bond; and Z is an alkylene, alkenylene or alkynylene group of up to 10 carbon atoms, have been found to possess anti-obesity and/or anti-hyperglycaemic activity.

Abstract: Compounds of formula (III): ##STR1## and esters, amides and pharmaceutically acceptable salts thereof, wherein A.sup.1 is hydrogen or methyl;A.sup.2 is hydrogen or methyl; andn is 1, 2 or 3have anti-obesity activity. Methods for their preparation pharmaceutical formulations of the compounds and their use in medicine are described.