Patents by Inventor David G. Zapol
David G. Zapol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240325672Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: October 25, 2023Publication date: October 3, 2024Applicant: Third Pole, Inc.Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Patent number: 11911566Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: GrantFiled: December 13, 2022Date of Patent: February 27, 2024Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Patent number: 11833309Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: GrantFiled: June 30, 2022Date of Patent: December 5, 2023Assignee: Third Pole, Inc.Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Publication number: 20230263986Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: ApplicationFiled: December 13, 2022Publication date: August 24, 2023Applicant: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Patent number: 11524134Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: GrantFiled: May 27, 2021Date of Patent: December 13, 2022Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Publication number: 20220339391Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: June 30, 2022Publication date: October 27, 2022Applicant: Third Pole, Inc.Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Patent number: 11376390Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: GrantFiled: March 10, 2021Date of Patent: July 5, 2022Assignee: Third Pole, Inc.Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Publication number: 20220047837Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: ApplicationFiled: May 27, 2021Publication date: February 17, 2022Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Publication number: 20210407080Abstract: Cell identification and classification is a well-known problem in the pathology domain that help identify microenvironments. In addition to the characteristic of each cell, its interactions with the neighboring regions or other cells is also important. This involves correct identification of neighboring elements and analytically representing the interactions between them. This disclosure presents a system that combines many such features, some hand engineered and some machine derived through training of Deep Learning algorithms that can be used to study the microenvironments.Type: ApplicationFiled: June 24, 2021Publication date: December 30, 2021Inventors: Evan Szu, Nishant Borude, Nivedita Suresh, Michael H. Chu, David G. Zapol, Vinona Bhatia, Darick M. Tong, Noriko Y. Tong, John Cheng, Clifford Szu, Eric J. Suba
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Publication number: 20210268221Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: March 10, 2021Publication date: September 2, 2021Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Patent number: 11033705Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: GrantFiled: December 21, 2019Date of Patent: June 15, 2021Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Patent number: 10946163Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: GrantFiled: June 23, 2020Date of Patent: March 16, 2021Assignee: Third Pole, Inc.Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Publication number: 20200390994Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: June 23, 2020Publication date: December 17, 2020Inventors: Ian J. Gillerman, Gregory W. Hall, Wolfgang Scholz, David G. Zapol
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Patent number: 10695523Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: GrantFiled: November 27, 2019Date of Patent: June 30, 2020Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Ian J. Gillerman
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Publication number: 20200139072Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: ApplicationFiled: December 21, 2019Publication date: May 7, 2020Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Publication number: 20200094011Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: November 27, 2019Publication date: March 26, 2020Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Ian J. Gillerman
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Patent number: 10576239Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: GrantFiled: March 25, 2019Date of Patent: March 3, 2020Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler, Andrew Ferencz
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Patent number: 10532176Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: GrantFiled: April 18, 2019Date of Patent: January 14, 2020Assignee: Third Pole, Inc.Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
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Publication number: 20190314596Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.Type: ApplicationFiled: April 18, 2019Publication date: October 17, 2019Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz
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Publication number: 20190217042Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.Type: ApplicationFiled: March 25, 2019Publication date: July 18, 2019Inventors: David G. Zapol, Gregory W. Hall, Wolfgang Scholz, Benjamin Apollonio, Frank Heirtzler