Patents by Inventor David Gaillac

David Gaillac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
    Patent number: 7378265
    Abstract: The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between ?5° C. and +50° C. and at a pH of between about 5 and 9. Its subject is also a method of preparing a viral preparation comprising such a method of inactivation. The invention also relates to a viral preparation obtained according to the method of the invention. Finally, it relates to a host cell and a composition comprising such a viral preparation as well as their uses for therapeutic or prophylactic purposes.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: May 27, 2008
    Assignee: Transgene S.A.
    Inventors: David Gaillac, Michel Koehl
  • Method for purifying plasmid DNA
    Publication number: 20070213289
    Abstract: This invention provides a process for the continuous alkaline lysis of a bacterial suspension in order to harvest pDNA. It further provides for optional additional purification steps, including lysate filtration, anion exchange chromatography, triplex affinity chromatogragphy, and hydrophobic interaction chromatography. These optional purification steps can be combined with the continuous lysis in order to produce a highly purified pDNA product substantially free of gDNA, RNA, protein, endotoxin, and other contaminants.
    Type: Application
    Filed: October 18, 2006
    Publication date: September 13, 2007
    Applicant: CENTELION
    Inventors: Francis Blanche, Michel Couder, Nicolas Maestrali, Thierry Guillemin, David Gaillac
  • Method for obtaining a purified viral preparation
    Patent number: 7264958
    Abstract: The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step of adsorption on a fluidised bed. The invention also concerns a protocol for producing viral particles for use in gene therapy comprising such a purifying process.
    Type: Grant
    Filed: February 21, 2000
    Date of Patent: September 4, 2007
    Assignee: Transgene, S.A.
    Inventors: Michel Koehl, David Gaillac
  • Method of preparation for pharmaceutical grade plasmid DNA
    Publication number: 20070111221
    Abstract: This invention provides a process for the continuous alkaline lysis of a bacterial suspension in order to harvest pDNA. It further provides for optional additional purification steps, including lysate filtration, anion exchange chromatography, triplex affinity chromatography, and hydrophobic interaction chromatography. These optional purification steps can be combined with the continuous lysis in order to produce a highly purified pDNA product substantially free of gDNA, RNA, protein, endotoxin, and other contaminants.
    Type: Application
    Filed: March 17, 2006
    Publication date: May 17, 2007
    Inventors: Francis Blanche, Michel Couder, Nicolas Maestrali, David Gaillac, Thierry Guillemin
  • Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
    Publication number: 20060166345
    Abstract: The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between ?5° C. and +50° C. and at a pH of between about 5 and 9. Its subject is also a method of preparing a viral preparation comprising such a method of inactivation. The invention also relates to a viral preparation obtained according to the method of the invention. Finally, it relates to a host cell and a composition comprising such a viral preparation as well as their uses for therapeutic or prophylactic purposes.
    Type: Application
    Filed: December 12, 2005
    Publication date: July 27, 2006
    Applicant: Transgene S.A.
    Inventors: David Gaillac, Michel Koehl
  • Method of inactivating enveloped viruses in a viral preparation of non-enveloped viruses
    Patent number: 7026154
    Abstract: The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between ?5° C. and +50° C. and at a pH of between about 5 and 9. Its subject is also a method of preparing a viral preparation comprising such a method of inactivation. The invention also relates to a viral preparation obtained according to the method of the invention. Finally, it relates to a host cell and a composition comprising such a viral preparation as well as their uses for therapeutic or prophylactic purposes.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: April 11, 2006
    Assignee: Transgene S.A.
    Inventors: David Gaillac, Michel Koehl