Abstract: A method and system for generating an interactive gaming platform is disclosed herein. A computing system generates an interactive marketplace. The computing system generates an initial book value based at least on historical performance of each athlete. The computing system generates an interactive game space for each event. The computing system monitors, for each event, one or more external data sources to identify one or more fantasy points scored by each player in the subset of players. The computing system generates a percentage of fantasy points earned in relation to subset of players associated with the event. The computing system allocates, for each event, the event pool to each player in accordance with the percentage of fantasy points earned by each player to generate a post-event book value.

Abstract: A method and system for generating an interactive gaming platform is disclosed herein. A computing system generates an interactive marketplace. The computing system generates an initial book value based at least on historical performance of each athlete. The computing system generates an interactive game space for each event. The computing system monitors, for each event, one or more external data sources to identify one or more fantasy points scored by each player in the subset of players. The computing system generates a percentage of fantasy points earned in relation to subset of players associated with the event. The computing system allocates, for each event, the event pool to each player in accordance with the percentage of fantasy points earned by each player to generate a post-event book value.

Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Abstract: Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5? end and polyA sequences coupled to a tag at the 3? end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3? ends of these molecules.

Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Abstract: New markers in the form of miRNA levels in plasma are provided for indicating the presence of CLL in a subject as well as suggesting routes of therapeutic treatment.

Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Abstract: Determination of the level and identity of various RNA molecules in circulation or tissues of subjects permits determination of microbiome composition and function of the subject as well as providing an index to health of various organs. Because rapid parallel sequencing techniques are available, such determinations can be conducted on a practical level.

Abstract: Disclosed are compositions and methods for detecting target RNA molecules. A specialized DNA probe can be used to form RNA/DNA hybrids with target RNA molecules. Separation of the RNA/DNA hybrids increases the ease and sensitivity of detection and quantitation of the target RNA molecules.

Abstract: Compositions and methods for protecting and administering small RNA to preserve stability are described. The small RNAs may either be in unmodified form or may be chemically modified to enhance stability further.

Abstract: Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5? end and polyA sequences coupled to a tag at the 3? end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3? ends of these molecules.

Abstract: New markers in the form of miRNA levels in plasma are provided for indicating the presence of CLL in a subject as well as suggesting routes of therapeutic treatment.

Abstract: Compositions and methods for protecting and administering small RNA to preserve stability are described. The small RNAs may either be in unmodified form or may be chemically modified to enhance stability further.

Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Abstract: The present invention provides genotyping analysis by liquid chromatographic analysis of short nucleic acid fragments. The nucleic acid fragments are amplification products using specifically designed oligonucleotides as primers and target nucleic acids containing nucleotides of interest as templates. The oligonucleotides contain recognition sequences for restriction endonucleases that cleave outside the recognition sequences. The short nucleic acid fragments can be rapidly and reliably analyzed using liquid chromatography, optionally followed by mass spectrometry, and the nucleotides of interest identified.