Abstract: This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer.

Abstract: A mat board is provided and is formed of a body having outer peripheral edges and an inner window formed therein. The inner window is defined by a sloped side wall that extends peripherally around the inner window and extends from a top surface of the body to a bottom surface of the body. The sloped side wall has an exposed convex surface, wherein corners of the inner window have curvature in that the top surface of the body in each corner is curved.

Abstract: An adapter cap is configured to convert a plastic water or drinking bottle into a nasal washing device. The cap has a connector portion or mechanism configured for engagement with the neck of a plastic water bottle in place of a conventional bottle cap, and a tapered applicator or spout portion having a tip with an opening which is configured for placing into a nostril of a user during a nasal washing procedure.

Abstract: A nasal passage washing device includes a pliable body including an open top; and an applicator cap removably attached to the pliable body to cover and uncover the open top. The applicator cap includes an applicator tip having a substantially frustoconical configuration sized and shaped for receipt at least partially within a nostril of a user for sealing engagement therewith, the applicator tip including a hole to transfer washing solution there through, a washing solution transfer tube in communication with the hole of the applicator tip and a bottom of an inside of the pliable body to transfer washing solution from the bottom of the inside of the pliable body to the hole of the applicator tip, and a one-way air valve that only allows air flow into the pliable body through the one-way air valve and does not allow air flow and washing solution flow out of the pliable body through the one-way air valve.

Abstract: Disclosed is a system and program for using storage slots efficiently. A storage element count is assigned to each one of multiple logical libraries, and the sum of the storage element count for each one of the multiple logical libraries exceeds the total number of storage slots in the library.

Abstract: A method of using a nasal wash system includes providing a nasal washing device including a container including a saline solution, a cap for the container, a delivery tube carried by the cap for withdrawing saline solution from the container, an atomizing nozzle for spraying the saline solution, a conduit carrying the atomizing nozzle, the conduit including a malleable portion, and a pump mechanism coupled to the malleable conduit and including a movable pump member; adjusting the malleable portion of the conduit to a desired configuration to control a point of impact of a discharge mist from the atomizing nozzle; and moving the movable pump member of the pump mechanism so that saline solution is withdrawn from the container through the delivery tube, through the pump mechanism, through the conduit, and sprayed out of the atomizing nozzle as a discharge mist, while the atomizing nozzle remains stationary.

Abstract: Disclosed is a system and program for using storage slots efficiently. A storage element count is assigned to each one of multiple logical libraries, and the sum of the storage element count for each one of the multiple logical libraries exceeds the total number of storage slots in the library.

Abstract: Disclosed is a method, system, and program for using storage slots efficiently. A storage element count is assigned to each one of multiple logical libraries, and the sum of the storage element count for each one of the multiple logical libraries exceeds the total number of storage slots in the library.

Abstract: A nasal passage washing device includes a pliable body including an open top; and an applicator cap removably attached to the pliable body to cover and uncover the open top. The applicator cap includes an applicator tip having a substantially frustoconical configuration sized and shaped for receipt at least partially within a nostril of a user for sealing engagement therewith, the applicator tip including a hole to transfer washing solution there through, a washing solution transfer tube in communication with the hole of the applicator tip and a bottom of an inside of the pliable body to transfer washing solution from the bottom of the inside of the pliable body to the hole of the applicator tip, and a one-way air valve that only allows air flow into the pliable body through the one-way air valve and does not allow air flow and washing solution flow out of the pliable body through the one-way air valve.

Abstract: A system, a method, and a computer program product to provide a failover procedure for an automated data storage library are provided. During the operation of a data storage library, a host computer issues control commands to the automated data storage library using one or more control paths. In the event that the host does not receive desirable results, such as when communication is lost between the host computer and the automated data storage library while a command is in process, the host computer may attempt to retry the same command using the same control path or an alternate control path. When the host issues a retry of the same command, the automated data storage library performs an examination of the command and one or more previous commands executed to prevent the automated data storage library from executing an identical command more than once.

Abstract: An apparatus, system, and method are disclosed for managing physical addresses of data storage media within a data storage library. The library maintains a data table of storage slots and the media stored in those slots. The data table may contain addresses for storage slots that are not physically present or accessible within the library. Hardware such as storage slots may be added or removed without causing an inconsistency within the data table of assigned addresses. Addresses may be recorded as the particular frame, column, and row that describe the location of a particular storage slot. Each data storage media is associated with a particular host. The data table of the library maintains a record of data storage media and the host affinity the media corresponds to.

Abstract: A high efficiency electrosurgical electrode with an advanced electrically conductive tip and aspiration port, and a method of conducting an electrosurgical procedure with such electrode. The electrosurgical electrode comprises an electrically conductive tip with a central lumen or “chimney” surrounded by a plurality of protuberances. The central lumen or “chimney” is “self-cleaning” and/or “self-clearing” in that any tissue passing through the central lumen that might cause a clog is quickly denatured by the surrounding electrode and aspirated from the ablation site, so that the probe does not require special consideration by the user (for example, replacement due to total loss of suction). The plurality of protuberances have various forms and geometries that define a plurality of recesses and that, in one embodiment, are provided in a “star-shaped” or partial “star-shaped” pattern.

Abstract: Disclosed are a system, a method, and an article of manufacture to provide for configuring an automated data storage library having one or more storage frames that operate with different types of data storage media. The automated data storage library is configured to operate with sequential storage shelf addresses assigned to consecutive storage frames that use the same type of data storage media. The storage frames that operate with different types of data storage media may be physically assembled in any order. The automated data storage library may be expanded by attaching storage frames that operate with different types of data storage media in any order while maintaining sequential storage shelf addresses that span across multiple library frames.

Abstract: Disclosed is a method, system, and program for using storage slots efficiently. A move command is received to move a portable data storage medium from a source address to a destination address. An empty storage slot that has no association with the destination address is located. The portable data storage medium is moved from the source address to the located empty storage slot. An association is stored between the located empty storage slot and the destination address.

Abstract: Drives of a data storage library are concurrently configured. A processor transmits library configuration data separately to each drive, initializes a first configuration process state, with a time-out period, for each drive. A drive responds with a status response, the first process state is updated to “completed”. A request for drive unique information is transmitted to the responding drive, advancing the process to a second state, with a time-out period. A drive responds with the information, and the second process state is updated to “completed”, and the received information is stored.